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Bombesin Receptors (Bombesin Receptor)

Subscribe to New Research on Bombesin Receptors

Cell surface proteins that bind bombesin or closely related peptides with high affinity and trigger intracellular changes influencing the behavior of cells. Gastrin- releasing peptide (GRP); GRP 18-27 (neuromedin C), and neuromedin B are endogenous ligands of bombesin receptors in mammals.

Also Known As:

Bombesin Receptor; Receptors, Bombesin; Gastrin-Releasing Peptide Receptor; Neuromedin B Receptor; B Receptor, Neuromedin; B Receptors, Neuromedin; Gastrin Releasing Peptide Receptor; Gastrin Releasing Peptide Receptors; Peptide Receptor, Gastrin-Releasing; Peptide Receptors, Gastrin-Releasing; Receptor, Bombesin; Receptor, Gastrin-Releasing Peptide; Receptor, Neuromedin B; Receptors, Gastrin Releasing Peptide; Gastrin-Releasing Peptide Receptors; Neuromedin B Receptors; Receptors, Gastrin-Releasing Peptide; Receptors, Neuromedin B

Networked: 353 relevant articles (14 outcomes, 37 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753

Experts

1.	Schwartsmann, Gilberto: 25 articles (01/2015 - 05/2004)
2.	Roesler, Rafael: 25 articles (01/2014 - 05/2004)
3.	Reubi, Jean Claude: 15 articles (01/2015 - 04/2002)
4.	Hoffman, Timothy J: 14 articles (02/2015 - 05/2003)
5.	Smith, Charles J: 12 articles (01/2016 - 04/2006)
6.	Sieckman, Gary L: 12 articles (04/2014 - 05/2003)
7.	Maecke, Helmut R: 11 articles (08/2015 - 09/2004)
8.	Chen, Xiaoyuan: 11 articles (10/2013 - 03/2006)
9.	Waser, Beatrice: 10 articles (08/2015 - 09/2004)
10.	Rold, Tammy L: 10 articles (02/2015 - 01/2007)

Related Diseases

1.	Neoplasms (Cancer) 12/03/2010 - "Evaluation of the conjugate in vitro and in vivo provided promising results for its use as an imaging agent for the visualization of tumors positive for the gastrin-releasing peptide receptor. " 01/01/2016 - "The impetus driving many of the research studies that we have described in this review is that the high-affinity gastrin releasing peptide receptor (GRPR, BBN receptor subtype 2, BB2) has been identified in tissue biopsy samples and immortalized cell lines of many human cancers and is an ideal biomarker for targeting early-stage disease. " 03/01/2014 - "Cellular uptakes studies indicated that BBN-based probes were mediated by gastrin-releasing peptide receptors (GRPR) on tumor cells and the PEG modified probe had higher affinity. " 02/01/2009 - "Preliminary in vivo studies of 64Cu-6 in NMRI nu/nu mice, bearing the human prostate tumor PC-3 showed an accumulation of the conjugate in the tumor (2.25 +/- 0.13 SUV, 12.5 min p.i.; 0.94 +/- 0.05 SUV, 55 min p.i.) and allowed a clear visualization of the gastrin-releasing peptide receptor distribution by positron emission tomography (PET)." 09/15/2004 - "The biodistribution studies of [111In]-BZH1 and [111In]-BZH2 ([177Lu]-BZH2) in AR4-2J tumor-bearing rats showed specific and high uptake in gastrin-releasing peptide-receptor-positive organs and in the AR4-2J tumor. "
2.	Prostatic Neoplasms (Prostate Cancer) 05/01/2015 - "For the treatment of prostate cancer, radiolabeled gastrin-releasing peptide receptor (GRPr) antagonists have yielded promising results in mouse models. " 05/01/2015 - "The gastrin-releasing peptide receptor (GRPR) is overexpressed in a variety of human malignancies, including prostate cancer. " 01/01/2015 - "Gastrin-releasing peptide receptor (GRPR) is known to be overexpressed in several human malignancies, including prostate cancer, and has been implicated in multiple important neoplastic signaling pathways. " 12/01/2014 - "Gastrin-releasing peptide receptor (GRPR) is overexpressed in human prostate cancer and is being used as a target for molecular imaging. " 12/01/2014 - "Preclinical comparison of Al18F- and 68Ga-labeled gastrin-releasing peptide receptor antagonists for PET imaging of prostate cancer."
3.	Pancreatic Neoplasms (Pancreatic Cancer) 03/21/2012 - "The gastrin-releasing peptide receptor (BB2r) has shown great promise for tumor targeting due to the increase of the receptor expression in a variety of human cancers including prostate, breast, small-cell lung, and pancreatic cancer. " 10/01/2015 - "Several types of tumors overexpress gastrin-releasing peptide receptors (GRPr), including pancreatic cancer cells. " 08/01/2008 - "The gastrin-releasing peptide receptor (GRP-R) is expressed in several normal human tissues and is overexpressed in various human tumors including breast, prostate, small-cell lung cancer and pancreatic cancer. " 01/01/2014 - "In this study, we investigated the efficacy of a combination of gastrin-releasing peptide receptor antagonist RC-3095 and gemcitabine on pancreatic cancer CFPAC-1. " 01/01/2014 - "RC-3095, a gastrin-releasing peptide receptor antagonist, synergizes with gemcitabine to inhibit the growth of human pancreatic cancer CFPAC-1 in vitro and in vivo."
4.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 12/01/1990 - "These results indicate the basis for the eventual design of improved, specific bombesin receptor antagonists and stimulate further studies on their possible application in the therapy of human small cell lung cancer." 02/01/2015 - "Novel cross-talk between gastrin-releasing peptide receptor cell signaling and Sonic hedgehog pathways was identified in small-cell lung carcinoma. " 12/01/2008 - "The gastrin-releasing peptide receptor is overexpressed in human prostate-, breast-, colon- and small cell lung carcinoma cells. " 04/01/2006 - "Targeting gastrin-releasing peptide receptors on small cell lung cancer cells with a bispecific molecule that activates polyclonal T lymphocytes." 01/01/1993 - "In vitro and in vivo activity of alkylating bombesin receptor antagonists on small cell lung carcinoma."
5.	Melanoma (Melanoma, Malignant) 01/01/1997 - "The newly characterized GRP-preferring bombesin receptors on highly malignant human melanoma cells could initiate studies of growth effects on solid tumours or in vivo scanning using radiolabelled tracers." 10/01/2013 - "Expression of gastrin-releasing peptide receptor in patients with cutaneous malignant melanoma." 01/01/1997 - "We therefore investigated whether human melanoma cell lines express functional GRP-preferring bombesin receptors and whether they alter growth or other specific cellular functions of these tumour cells. " 01/01/1997 - "Identification of functional GRP-preferring bombesin receptors on human melanoma cells." 05/01/1998 - "Functional bombesin receptors mediating mitogenic effects were demonstrated on Swiss 3T3 fibroblasts, human melanoma cells (A375-6) and primary human lung fibroblasts; however, bombesin-related STAT protein activation was not observed by EMSA. "

Related Drugs and Biologics

1.	Bombesin
2.	Bombesin Receptors (Bombesin Receptor)
3.	Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)- bombesin (6-14)
4.	Somatostatin (Somatotropin Release-Inhibiting Factor)
5.	Carbon Monoxide
6.	Melanocyte-Stimulating Hormones (MSH)
7.	Metronidazole (Metric)
8.	Aluminum
9.	alpha-MSH
10.	gemcitabine

Related Therapies and Procedures

1.	Radiotherapy
2.	Heterologous Transplantation (Xenotransplantation)
3.	Photochemotherapy (Photodynamic Therapy)
4.	Brachytherapy