Calcitonin Receptors (Calcitonin Receptor)

Cell surface proteins that bind calcitonin and trigger intracellular changes which influence the behavior of cells. Calcitonin receptors outside the nervous system mediate the role of calcitonin in calcium homeostasis. The role of calcitonin receptors in the brain is not well understood.

Also Known As:

Networked: 211 relevant articles (5 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Henriksen, Kim: 12 articles (12/2021 - 09/2015)
2.	Wookey, Peter J: 8 articles (01/2022 - 08/2009)
3.	Karsdal, Morten A: 6 articles (12/2021 - 09/2015)
4.	Davey, Rachel A: 6 articles (10/2021 - 02/2004)
5.	Zajac, Jeffrey D: 6 articles (10/2021 - 02/2004)
6.	Gydesen, Sofie: 6 articles (01/2021 - 09/2015)
7.	Karsdal, Morten Asser: 6 articles (01/2021 - 01/2016)
8.	Sonne, Nina: 6 articles (01/2021 - 01/2017)
9.	Hare, David L: 5 articles (01/2021 - 08/2009)
10.	Andreassen, Kim Vietz: 5 articles (01/2020 - 01/2016)

Related Diseases

1.	Body Weight (Weight, Body) 10/05/2021 - "The calcitonin receptor is the main mediator of LAAMA's body weight lowering effects in male mice." 01/01/2021 - "Calcitonin receptor (Calcr)-expressing neurons of the nucleus tractus solitarius (NTS; CalcrNTS cells) contribute to the long-term control of food intake and body weight. " 01/01/2020 - "Dose Frequency Optimization of the Dual Amylin and Calcitonin Receptor Agonist KBP-088: Long-Lasting Improvement in Food Preference and Body Weight Loss." 01/01/2021 - "The long-acting amylin/calcitonin receptor agonist ZP5461 suppresses food intake and body weight in male rats." 01/01/2020 - "In rats, studies with dual amylin and calcitonin receptor agonists have demonstrated robust body weight loss, improved glucose tolerance and a decreased deposition of fat in liver tissue beyond what is observed after a body weight loss. "
2.	Bone Resorption 10/01/2021 - "Calcitonin receptor (Calcr) is a miR-29 target that negatively regulates bone resorption. " 03/01/1992 - "Cells of osteoclastic phenotype [as judged by calcitonin receptor (CTR) expression or bone resorption] were observed only in multilineage colonies. " 02/01/1991 - "We have therefore tested the effects of PG E1, E2, and F2 alpha on the differentiation of osteoclastic phenotype in mouse bone marrow cultures using bone resorption and calcitonin receptors (CTR) as markers of osteoclastic differentiation. " 02/01/2011 - "The role of the calcitonin receptor in protecting against induced hypercalcemia is mediated via its actions in osteoclasts to inhibit bone resorption." 05/01/1999 - "Unexpectedly, infection of bipotential osteoclast-macrophage precursor cell lines with retroviruses expressing Fra-1 but not c-Fos caused a 10-100-fold increase in the number of precursors that developed calcitonin receptors associated with an increase in bone resorption. "
3.	Pain (Aches) 01/01/2015 - "Immunohistochemistry staining and western blot analyses were used to assess the distribution and expression of calcitonin receptor (CT-R) in the midbrain periaqueductal gray (PAG), which was a pivotal site in the modulatory system for the endogenous pain. " 03/10/2000 - "Calcitonin receptor mRNA was expressed in various brain regions, including the preoptic area, dorsomedial hypothalamic nucleus, lateral hypothalamic area, periaqueductal gray, dorsal raphe nucleus, locus coeruleus, lateral parabrachial nucleus, gigantocellular reticular nucleus alpha part, lateral paragigantocellular nucleus, raphe magnus nucleus and solitary tract nucleus, which are known to play important roles in pain modulation. " 01/01/2019 - "A dual amylin and calcitonin receptor agonist inhibits pain behavior and reduces cartilage pathology in an osteoarthritis rat model." 01/01/2019 - "Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model." 01/01/2004 - "Immunohistological reports have shown that the amount of neurotransmitters, such as substance P and its receptor, calcitonin gene-related peptide and other neurotransmitters, are increased in afferent pancreatic nerves and a correlation between pain and immune cell infiltration of the nerves has been reported in CP. "
4.	Migraine Disorders (Migraine) 01/01/2022 - "Using a validated antibody, calcitonin receptor-like immunoreactivity was detected in several brain regions relevant to migraine. " 01/01/2022 - "Selected migraine-relevant rat brain regions were then examined for calcitonin receptor-like immunoreactivity. " 12/01/2019 - "Calcitonin receptor-like (CALCRL) is a G-protein-coupled neuropeptide receptor involved in the regulation of blood pressure, angiogenesis, cell proliferation, and apoptosis, and is currently emerging as a novel target for the treatment of migraine. " 04/01/2017 - "The recent identification of the CGRP-responsive calcitonin receptor/RAMP1 complex (AMY1 receptor - amylin subtype 1 receptor) in the trigeminovascular system warrants a deeper consideration of the molecular identity of CGRP receptor(s) involved in the pathophysiology, and thus potential treatment of migraine. " 05/01/2011 - "CGRP, an important mediator of migraine pathogenesis, and the 3 components of its receptor, calcitonin-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and receptor component protein (RCP) mRNAs were quantified in the trigeminal ganglion and medulla to identify baseline sex differences and changes associated with application of IS or PBS to the dura. "
5.	Obesity 09/05/2023 - "Long-acting dual amylin and calcitonin receptor agonists (DACRAs) hold great promise as potential treatments for obesity and its associated comorbidities. " 01/01/2017 - "Here, we studied the role of Calca-derived peptides in diet-induced obesity (DIO) by challenging Calcr-/- (encoding the calcitonin receptor, CTR), Calca-/-, and αCGRP-/- mice and their respective littermates with high-fat diet (HFD) feeding for 16 weeks. " 11/01/2023 - "Dual amylin and calcitonin receptor agonists (DACRAs) are effective treatments for obesity and type 2 diabetes (T2D). " 09/22/2022 - "Dual Amylin and Calcitonin Receptor Agonists (DACRAs) are treatment candidates for obesity and type 2 diabetes. " 08/03/2023 - "Amylin receptors (AMYRs), heterodimers of the calcitonin receptor (CTR) and one of three receptor activity-modifying proteins, are promising obesity targets. "

Related Drugs and Biologics

1.	Islet Amyloid Polypeptide
2.	Glucose (Dextrose)
3.	Calcitonin Receptors (Calcitonin Receptor)
4.	Proteins (Proteins, Gene)
5.	Tartrate-Resistant Acid Phosphatase
6.	Cathepsin K
7.	KBP-088
8.	Calcitonin Gene-Related Peptide
9.	Receptor Activity-Modifying Protein 1
10.	Monoclonal Antibodies

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)
2.	Therapeutics
3.	Lasers (Laser)
4.	Debridement
5.	Glycemic Control