Leukotriene C4

The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)

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Networked: 753 relevant articles (18 outcomes, 72 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kanaoka, Yoshihide: 7 articles (10/2015 - 10/2004)
2.	Haeggström, Jesper Z: 6 articles (02/2014 - 07/2008)
3.	Park, Hae-Sim: 5 articles (11/2007 - 03/2004)
4.	Boyce, Joshua A: 4 articles (10/2015 - 01/2003)
5.	Kotsiuruba, A V: 4 articles (01/2014 - 01/2002)
6.	Austen, K Frank: 4 articles (04/2013 - 10/2004)
7.	Lou, Yi-Jia: 4 articles (05/2008 - 01/2007)
8.	Kim, Seung-Hyun: 4 articles (11/2007 - 01/2006)
9.	Tsugeno, H: 4 articles (03/2001 - 02/2000)
10.	Tanizaki, Y: 4 articles (03/2001 - 02/2000)

Related Diseases

1.	Asthma (Bronchial Asthma) 05/01/1991 - "In addition, the leukotriene C4 values in asthmatic patients during acute asthma were larger than in asthmatic patients during remission or control subjects without a significant difference. " 05/01/1990 - "This inhibition could be beneficial in the therapy of such diseases as bronchial asthma in which release of LTC4 may be involved in the inflammatory process." 01/01/2014 - "Our objective was to determine the efficacy of a botanical seed oil combination against airflow obstruction in asthma, and to determine the pharmacogenomic effect of the leukotriene C4 synthase (LTC4S) polymorphism A-444C. " 08/01/2012 - "The -444A/C polymorphism in the leukotriene C4 synthase (LTC4S) gene has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. " 03/01/2004 - "A recent study has demonstrated the possible involvement of a leukotriene C4 synthase (LTC4S) gene polymorphism in ASA-intolerant asthma (AIA) in a Polish population, whereas no significant association was noted in other populations. "
2.	Anaphylaxis (Anaphylactic Shock) 08/01/1987 - "It is concluded that systemic anaphylaxis in the guinea pig is associated with endogenous generation of leukotriene C4 (up to 1 nmol/kg during a 30-min period after the challenge." 08/01/1983 - "LTC4 is a potent vasoconstrictor and negative inotropic agent and may play an important role in anaphylactic shock." 04/01/1979 - "Double bonds, asthma, anaphylaxis and leukotriene C." 12/01/1989 - "This inhibition of systemic LTC4 formation was associated with a complete protection against lethal anaphylactic shock in animals pretreated in addition with the H1 receptor antagonist pyrilamine. " 12/01/1989 - "To mimic the elimination and metabolism of endogenous LTC4 generated during anaphylaxis, 14,15-3H-labeled LTC4 was infused intravenously over a period of 15 min, leading to a recovery in bile of 85% of the infused LT radioactivity within 2 h. "
3.	Reperfusion Injury 09/01/2003 - "Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist." 03/01/1995 - "Our findings indicated that reperfusion, which was associated with translocation of cytosolic 5-LO to membranes and generation of oxygen radicals, induced the production of LTC4 and suggested that excess LTC4 production may mediate irreversible reperfusion injuries in the hippocampal neurons." 04/01/1988 - "These results suggest that lipoxygenase products, especially peptidoleukotrienes (LTC4, D4 and E4) may play important roles in the pathogenesis of myocardial ischemic and reperfusion injuries." 12/01/1992 - "The LTC4/PGE2 ratio was low and histologic findings were worse in group III. In conclusion, iloprost was found to be beneficial in preventing the ischemia-reperfusion injury in the rat livers. " 04/01/1996 - "The effect of aqueous garlic extract on the levels of arachidonic acid metabolites (leukotriene C4 and prostaglandin E2) in rat forebrain after ischemia-reperfusion injury."
4.	Eosinophilia 06/01/2015 - "We recently found that LTC4, the parent cysLT, potently activates platelets in vitro and induces airway eosinophilia in allergen-sensitized and -challenged mice by a platelet- and type 2 cysLT receptor-dependent pathway. " 11/01/2004 - "At the time of surgery, blood was drawn to determine the level of peripheral eosinophilia and the degree of polymorphisms of the leukotriene C4 synthase gene. " 06/01/1996 - "The purified preparation was active in vitro and in vivo as determined by its ability to prime human basophils to release leukotriene C4 in the presence of C5a and to induce airway eosinophilia in naive guinea pigs." 04/01/1987 - "Leukotriene C4 production by normal-density and low-density eosinophils of atopic individuals and other patients with eosinophilia." 12/01/1983 - "The predominant production by human eosinophils of LTC4 with its potent smooth muscle spasmogenic and vasoactive properties may contribute to the pathobiology of allergic and other diseases associated with eosinophilia."
5.	Sneezing 02/01/2014 - "40 °C normal saline nasal irrigation can improve the symptoms of sneezing and nasal obstruction and can alleviate the local levels of inflammatory factors like histamine and LTC4 in AR patients, and is the appropriate irrigation temperature." 02/01/2014 - "Pre-intervention and post intervention whether is VAS scores of rhinorrhea, sneezing, nasal obstruction and nasal pruritis or in contents of histamine, LTC4, sIgE and ECP showed no difference (all P > 0.05). " 08/01/1987 - "Histamine caused sneezing, itching, rhinorrhea, and nasal obstruction; conversely, the main symptom induced by LTC4 was a more pronounced and longer lasting nasal obstruction." 06/01/1989 - "The results showed a significant reduction in sneezing and in the amounts of recovered albumin, TAME-esterase activity, and leukotriene C4 but no reduction in the amounts of recovered histamine and prostaglandin D2. " 09/01/1993 - "Loratadine markedly, but not significantly, inhibited the sneezing response and reduced release of histamine, PGD2, and LTC4. "

Related Drugs and Biologics

1.	Leukotriene B4
2.	Leukotriene D4
3.	Histamine (Histamine Dihydrochloride)
4.	Dinoprostone (PGE2)
5.	Leukotrienes
6.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
7.	Leukotriene E4
8.	Prostaglandin D2
9.	Lipoxygenase (Lipoxygenase-1)
10.	Platelet Activating Factor

Related Therapies and Procedures

1.	Ligation
2.	Intra-Arterial Infusions
3.	Artificial Eye (Artificial Eyes)
4.	Injections
5.	Intravenous Injections