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Growth Factor Receptors

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Cell surface receptors that bind growth or trophic factors with high affinity, triggering intracellular responses which influence the growth, differentiation, or survival of cells.

Also Known As:

Receptors, Growth Factor; Receptors, Growth Factors; Receptors, Trophic Factor; Trophic Factor Receptor; Factor Receptor, Trophic; Growth Factors Receptors; Receptor, Trophic Factor; Trophic Factor Receptors

Networked: 766 relevant articles (9 outcomes, 53 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753
      - Peptide Receptors: 579
        Growth Factor Receptors: 766
        Epidermal Growth Factor Receptor: 16151
        Vascular Endothelial Growth Factor Receptors: 2153
        Platelet-Derived Growth Factor Receptors: 1433
        Fibroblast Growth Factor Receptors: 814
        Transforming Growth Factor beta Receptors: 715
        erbB-2 Receptor: 459
        Proto-Oncogene Proteins c-met: 353
        Somatomedin Receptors: 289
        Nerve Growth Factor Receptors: 235
        Bone Morphogenetic Protein Receptors: 116
        erbB-3 Receptor: 15
        Colony-Stimulating Factor Receptors: 14
        biotin receptor: 12
        midkine receptors: 2
        agrin receptor: 1
        Callithrix jacchus VEGF Trap R1R2 protein
        decorin receptor
        erythroid differentiation factor receptor
        human MDGF1 protein
        human MET protein
        mouse proliferin receptor
        neurite outgrowth factor receptor
        rat Ngfr protein
        vasculotropin receptor

Experts

1.	Gründker, Carsten: 4 articles (01/2008 - 01/2002)
2.	Emons, Günter: 4 articles (01/2008 - 01/2002)
3.	Ramon y Cajal, Santiago: 3 articles (08/2013 - 10/2006)
4.	Bast, Robert C: 3 articles (01/2012 - 01/2006)
5.	Nicholson, Robert I: 3 articles (01/2012 - 07/2007)
6.	Esteva, Francisco J: 3 articles (02/2010 - 01/2003)
7.	van Diest, P J: 3 articles (10/2009 - 04/2001)
8.	Zhu, Zhenping: 3 articles (01/2009 - 03/2006)
9.	Günthert, Andreas R: 3 articles (01/2008 - 01/2002)
10.	Fu, Jian: 2 articles (09/2015 - 11/2005)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2001 - "The study shows that clear cell tumors are able to up-regulate angiogenic growth factor receptors more efficiently than chromophil (papillary), that clear cell tumors can use pathways independent of VHL to regulate angiogenesis, and that this combined regulation may account for their more aggressive phenotype, which suggests that targeting VEGFR1 (flt-l) may be particularly effective in these tumor types." 01/01/2011 - "In conclusion, our in vitro study suggests that one contributing factor to the minor responses obtained with EGFR-directed therapy may be downregulation of this receptor in tumor cell aggregates, possibly resulting in acquisition of a more aggressive phenotype via other growth factor receptors like NTR1. " 06/05/2009 - "Here, we describe the potential of applying functional genomics and proteomics, taking the ERBB family of growth-factor receptors as an example to study the signaling network and its impact on cancer." 01/07/2008 - "Clinical trials indicate that growth factor receptors and their related signalling pathways play important roles in HCC cancer etiology and progression, thus providing rational targets for innovative cancer therapies. " 12/01/2005 - "Tumor biology studies have revealed a central role for growth factor receptors in tumor progression. "
2.	Hepatocellular Carcinoma (Hepatoma) 01/07/2008 - "Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer." 09/01/2015 - "In conclusion, the data suggest that SF2 contributes to the elevated levels of ERK activation in hepatocellular carcinoma cells through modulating key component(s) downstream of growth factor receptors and upstream of ERK." 06/01/2011 - "Targeted therapies against insulinlike growth factor receptors may be justifiable in the treatment of hepatocellular carcinoma." 12/01/2007 - "Expression of oestrogen and growth factor receptors in hepatocellular carcinoma." 03/01/2014 - "Gene expression of growth factors and growth factor receptors for potential targeted therapy of canine hepatocellular carcinoma."
3.	Prostatic Neoplasms (Prostate Cancer) 06/27/2003 - "Targeting intermediate cells by inhibition of their peptide growth factor receptors, therefore, offers novel treatment modalities for prostate cancer." 09/01/2013 - "Our results identify NTG as a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors (GFRs), thereby efficiently synergizing with TRAIL exposure. " 03/01/2008 - "Because Vav3 may be chronically activated in prostate cancer by growth factor receptors, we examined the effects of a constitutively active (Ca) form of Vav3 on AR transcriptional activity. " 11/01/2006 - "During its biological progression, prostate cancer frequently develops dependence on growth factor receptors and their downstream signalling messengers, including c-Src. " 02/10/2005 - "Endocytosis of growth factor receptors, one of the mechanisms that controls growth factor signalling, was observed to be markedly changed in advanced metastatic prostate cancer. "
4.	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 01/01/2008 - "We evaluated safety and efficacy of PTK787/ZK222584 (PTK/ZK), a novel tyrosine kinase inhibitor of KIT, platelet-derived growth factor receptors and vascular endothelial cell growth factor receptors (VEGFRs), in patients with imatinib-resistant gastrointestinal stromal tumor (GIST). "
5.	Keratoconjunctivitis Sicca 04/01/2000 - "The expression of the type 1 growth factor receptors is significantly greater in the conjunctival epithelium of eyes with keratoconjunctivitis sicca than normal eyes. " 04/01/2000 - "To investigate the expression of type 1 growth factor receptors (epidermal growth factor receptor, ErbB2, and ErbB3) in the conjunctival epithelium of patients with keratoconjunctivitis sicca. "

Related Drugs and Biologics

1.	Protein-Tyrosine Kinases (Tyrosine Kinase)
2.	Antibodies
3.	vatalanib (PTK787)
4.	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)
5.	imatinib (Gleevec)
6.	Glycoproteins (Glycoprotein)
7.	axitinib (AG 013736)
8.	castanospermine
9.	Intercellular Signaling Peptides and Proteins (Growth Factors)
10.	Epidermal Growth Factor Receptor (EGF Receptor)

Related Therapies and Procedures

1.	Immunotherapy
2.	Immunomodulation
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)
5.	Radiotherapy