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alpha-Linolenic Acid (Linolenic Acid)

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A fatty acid that is found in plants and involved in the formation of prostaglandins.

Also Known As:

Linolenic Acid; Linolenate; alpha-Linolenic Acid, (E,E,E)-Isomer; alpha-Linolenic Acid, (E,E,Z)-Isomer; alpha-Linolenic Acid, (E,Z,E)-Isomer; alpha-Linolenic Acid, (E,Z,Z)-Isomer; alpha-Linolenic Acid, (Z,E,E)-Isomer; alpha-Linolenic Acid, (Z,E,Z)-Isomer; alpha-Linolenic Acid, (Z,Z,E)-Isomer; alpha-Linolenic Acid, Ammonium Salt; alpha-Linolenic Acid, Calcium Salt; alpha-Linolenic Acid, Lithium Salt; alpha-Linolenic Acid, Magnesium Salt; alpha-Linolenic Acid, Potassium Salt; alpha-Linolenic Acid, Sodium Salt; alpha-Linolenic Acid, Tin(2+) Salt; alpha-Linolenic Acid, Zinc Salt; alpha Linolenic Acid; alpha Linolenic Acid, Ammonium Salt; alpha Linolenic Acid, Calcium Salt; alpha Linolenic Acid, Lithium Salt; alpha Linolenic Acid, Magnesium Salt; alpha Linolenic Acid, Potassium Salt; alpha Linolenic Acid, Sodium Salt; alpha Linolenic Acid, Zinc Salt; 9,12,15-Octadecatrienoic acid, (Z,Z,Z)-

Networked: 605 relevant articles (20 outcomes, 96 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 18571
- Fatty Acids: 6864
  - Unsaturated Fatty Acids: 3881
- Fats: 1479
  - Dietary Fats: 3047
    - Unsaturated Dietary Fats: 75
      - Omega-3 Fatty Acids: 3035
        alpha-Linolenic Acid: 605
        perilla seed oil: 46
        volicitin: 3
        (E,E,Z)-2,4,6-nonatrienal
        9 epimer 9(R)-11-((2'S,8'S,10'S,11'R)-2',8'-dihydroxy-7'-oxo-11'-((Z)-2-pentenyl)-9'-oxa-4'-azatricyclo (6.3.1.0(1.5))dodec-5'en-10'-yl)-9-hydroxy-10-oxoundecanoic acid
        9(R)-11-((2'S,8'S,10'S,11'R)-2',8'-dihydroxy-7'-oxo-11'-((Z)-2-pentenyl)-9'-oxa-4'-azatricyclo(6.3.1.0(1.5))dodec- 5'en-10'-yl)-9-hydroxy-10-oxoundecanoic acid
        9-hydroxy-10-oxo-12,15-octadecadienoic acid
        cholesteryl linolenate

Experts

1.	Das, Undurti N: 10 articles (10/2015 - 05/2005)
2.	Mozaffarian, Dariush: 7 articles (10/2014 - 02/2003)
3.	Lemaitre, Rozenn N: 6 articles (10/2014 - 02/2003)
4.	Sasaki, Satoshi: 6 articles (11/2013 - 12/2006)
5.	Campos, Hannia: 6 articles (12/2012 - 04/2003)
6.	Djoussé, Luc: 6 articles (08/2012 - 04/2003)
7.	Blondeau, Nicolas: 5 articles (01/2016 - 09/2003)
8.	Kromhout, Daan: 5 articles (05/2015 - 04/2010)
9.	Geleijnse, Johanna M: 5 articles (05/2015 - 04/2010)
10.	Thompson, Lilian U: 5 articles (04/2015 - 01/2002)

Related Diseases

1.	Cardiovascular Diseases (Cardiovascular Disease) 04/01/2010 - "It is at present unclear whether alpha-linolenic acid (ALA), a n-3 fatty acid from vegetable origin, could also be protective against cardiovascular diseases (CVDs). " 12/01/2012 - "Prior studies of α-linolenic acid (ALA), a plant-derived omega-3 (n-3) fatty acid, and cardiovascular disease (CVD) risk have generated inconsistent results. " 01/01/2009 - "Several studies have shown that dietary alpha-linolenic acid (ALA) is associated with a reduced risk of cardiovascular disease and has an antihypertensive effect. " 11/01/2001 - "Studies in humans and animals also reported an inverse association between alpha-linolenic acid and cardiovascular disease morbidity and mortality. " 11/01/2014 - "Our understanding of the cardiovascular disease (CVD) benefits of α-linolenic acid (ALA, 18:3n-3) has advanced markedly during the past decade. "
2.	Inflammation 10/28/2014 - "Plant-derived α-linolenic acid (ALA) may reduce the risk of CVD, possibly by decreasing systemic inflammation and improving endothelial function. " 10/01/2014 - "This suppression was not observed by the intake of the γ-linolenic acid-producing (C18:3n-6, an immediate precursor of DGLA) yeast, indicating DGLA itself suppressed the inflammation. " 12/01/2012 - "Synergistic effect of conjugated linolenic acid isomers against induced oxidative stress, inflammation and erythrocyte membrane disintegrity in rat model." 01/01/2012 - "To investigate the effects of alpha-linolenic acid (ALA) on inflammation and oxidative stress in the diabetic rats. " 01/01/2012 - "[Effects of alpha-linolenic acid on inflammation and oxidative stress in the diabetic rats]."
3.	Atherosclerosis 05/01/2015 - "The association of dietary alpha-linolenic acid with blood pressure and subclinical atherosclerosis in people born small for gestational age: the Special Turku Coronary Risk Factor Intervention Project study." 04/01/2014 - "The effect of α-linolenic acid from a flaxseed (FLX)-enriched diet on plasma lipid and fatty acid metabolism and possible atherosclerosis risk factors was studied in Monk parrots (Myiopsitta monachus). " 07/01/2010 - "The atheroprotective potential of n-3 alpha-linolenic acid (ALA) has not yet been fully determined, even in murine models of atherosclerosis. " 09/01/2007 - "Dietary alpha-linolenic acid (ALA) has been associated with reduced risk of development of atherosclerosis. " 06/07/2005 - "However, little is known about the association between linolenic acid and subclinical atherosclerosis. "
4.	Myocardial Infarction 05/01/1996 - "A recent dietary intervention trial in post-myocardial infarction patients has renewed the interest for alpha-linolenic acid, both as the metabolic precursor of eicosapentaenoic and docosahexaenoic acid, and as a fatty acid with direct specific properties." 07/01/1995 - "In a 5-year study of survivors of a first myocardial infarction, the effect of an alpha-linolenic acid-enriched diet (experimental) was compared with the prudent diet of the American Heart Association (control) in prevention of secondary coronary events. " 04/01/2011 - "Epidemiological studies indicated that consumption of α-linolenic acid (ALA) significantly reduces the risk of cardiac events in post-acute myocardial infarction patients. " 07/22/2008 - "The relationship between alpha-linolenic acid and myocardial infarction was nonlinear; risk did not decrease with intakes > approximately 0.65% energy (1.79 g/d). " 07/22/2008 - "The odds ratios for nonfatal myocardial infarction for the highest compared with the lowest deciles were 0.41 (95% confidence interval, 0.25 to 0.67) for alpha-linolenic acid in adipose tissue and 0.61 (95% confidence interval, 0.42 to 0.88) for dietary alpha-linolenic acid. "
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 12/01/2015 - "α-Linolenic acid (ALA) is an anti-inflammatory agent in inflammatory bowel disease." 01/01/1996 - "The effect of alpha-linolenic acid-rich emulsion on fatty acid metabolism and leukotriene generation of the colon in a rat model with inflammatory bowel disease." 01/01/1996 - "The nutritional effect of a-linolenic acid-rich emulsion with total parenteral nutrition in a rat model with inflammatory bowel disease." 11/14/2012 - "Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease." 01/01/1996 - "The purpose of this study was to investigate the efficacy of alpha-linolenic acid-rich perilla oil emulsion (POE) in a rat model with trinitrobenzenesulfonic acid (TNB)-induced inflammatory bowel disease. "

Related Drugs and Biologics

1.	Linoleic Acid (Linoleate)
2.	Eicosapentaenoic Acid
3.	Omega-3 Fatty Acids (Omega 3 Fatty Acids)
4.	Fatty Acids (Saturated Fatty Acids)
5.	Linseed Oil (Flaxseed Oil)
6.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)
7.	Arachidonic Acid (Vitamin F)
8.	Oils
9.	perilla seed oil
10.	Plant Oils (Vegetable Oils)

Related Therapies and Procedures

1.	Vegetarian Diet (Vegetarianism)
2.	Enteral Nutrition (Feeding, Tube)
3.	Induced Hypothermia
4.	Transplants (Transplant)
5.	Transplantation (Transplant Recipients)