Isocyanates

10/01/1997 - "A better outcome in OA induced by isocyanates was associated with early diagnosis (P < 0.05), and early removal from isocyanates after the onset of asthma. "
12/14/2021 - "PubMed and Cochrane databases were systematically searched for studies published since 1990 that assessed the relationship between occupational exposure to isocyanates and asthma. "
04/20/2015 - "The present study provides in vivo evidence that a GSH mediated pathway underlies asthma-like eosinophilic inflammatory responses to respiratory tract isocyanate exposure. "
03/01/2009 - "The current study provides evidence that exposure to isocyanate oligomers is related to asthma with bronchial hyperresponsiveness as a hallmark, but also shows independent chronic obstructive respiratory effects resulting from isocyanate exposure."
03/01/2000 - "Animal studies have suggested that skin exposure to isocyanates may be an important risk factor for respiratory sensitization leading to asthma. "

01/01/2018 - "This study investigating occupational exposure to isocyanates in a national working population provides information that can be used to inform the direction of occupational interventions and policies to decrease occupational asthma."
08/01/2013 - "(1) A total of 366 patients with complete data were included in the study, and finally 11 cases were diagnosed as isocyanate-induced occupational asthma with a prevalence of 3.0%. "
12/01/2000 - "By contrast with other studies, smoking and atopy seemed to increase the odds of occupational asthma due to isocyanates, but did not affect the estimate of risk associated with exposure."
11/20/1999 - "A descriptive-evolutive study of a series of patients diagnosed with bronchial occupational asthma due to isocyanate exposure. "
11/20/1999 - "[Occupational asthma due to isocyanates: a study of 21 patients]."

01/01/2014 - "Our study has identified methyl isocyanates may contribute to the anticancer activity in part by interfering with tumor angiogenesis. "
09/01/1981 - "(Such studies are already in progress or are in the planning stage.) At the moment, it is absolutely unjustifiable to suggest that isocyanates--provided that the customary TLV values are observed--represent a serious health hazard to man in the form of cancer or genetic damage."
09/01/2014 - "Treatment of 2',3',5'-O-acetyladenosine with aryl isocyanates gave the 6-ureido derivatives but none of them exhibited inhibitory activity against cancer cell proliferation or hENT1."
04/01/2002 - "The overall conclusion is that because humans are not exposed to high levels of respiratory isocyanate particles, concerns over the possible development of lung tumors should not be relevant. "
04/01/1992 - "The present results suggest that carbamoylation of amino groups in cellular constituents by N-nitrosoureas is a critical factor in inducing mouse skin tumors by the agents and that the generated isocyanates may not be the key intermediates for the carbamoylation reactions."

07/01/1991 - "[A case of isocyanate-induced hypersensitivity pneumonitis and a compression-air mask thought to be effective in its prevention]."
04/01/2013 - "The objective of this present study was to describe the clinical-radiological and lung function characteristics of hypersensitivity pneumonitis due to exposure to isocyanates (HPI). "
05/01/1995 - "The purpose of this study was to find out whether hypersensitivity pneumonitis is a common disorder in isocyanate workers. "
04/01/2013 - "Hypersensitivity pneumonitis due to isocyanates: lung function, clinical and radiological characteristics."
06/01/2012 - "Hypersensitivity pneumonitis due to isocyanate exposure in an airbag "welder"."

01/13/1979 - "[Concerning: Bernoulli R., Engelhart G., Velvart J.: "Peroral poisoning with isocyanate and methylenechloride." Schweiz. "
06/10/1978 - "[Peroral poisoning with isocyanate and methylenechloride]."
11/21/1975 - "[Isocyanate poisoning]."
01/27/1963 - "[Subacute isocyanate poisoning, a new industrial poisoning]."
01/01/1951 - "[Clinical and experimental study of some cases of poisoning by desmodur T (1-2-4 and 1-2-6 di-isocyanates of toluene)]."