Isocyanates

10/01/1997 - "A better outcome in OA induced by isocyanates was associated with early diagnosis (P < 0.05), and early removal from isocyanates after the onset of asthma. "
12/01/2000 - "By contrast with other studies, smoking and atopy seemed to increase the odds of occupational asthma due to isocyanates, but did not affect the estimate of risk associated with exposure."
03/01/2000 - "Animal studies have suggested that skin exposure to isocyanates may be an important risk factor for respiratory sensitization leading to asthma. "
11/20/1999 - "[Occupational asthma due to isocyanates: a study of 21 patients]."
11/01/1987 - "Several studies on the prognosis of isocyanate-induced asthma show that a significant proportion of patients continue to experience asthmatic symptoms and nonspecific bronchial hyperresponsiveness after cessation of work, and that further exposure to isocyanates in sensitized subjects leads almost invariably to persistence of respiratory symptoms and of bronchial hyperresponsiveness and the deterioration of airway function. "

01/01/2014 - "Our study has identified methyl isocyanates may contribute to the anticancer activity in part by interfering with tumor angiogenesis. "
09/01/2014 - "Treatment of 2',3',5'-O-acetyladenosine with aryl isocyanates gave the 6-ureido derivatives but none of them exhibited inhibitory activity against cancer cell proliferation or hENT1."
06/01/1993 - "Poison regression did not indicate that ever having been employed in jobs attracting either higher or lower exposure to isocyanates was a risk factor for the mentioned cancers. "
04/01/1992 - "The present results suggest that carbamoylation of amino groups in cellular constituents by N-nitrosoureas is a critical factor in inducing mouse skin tumors by the agents and that the generated isocyanates may not be the key intermediates for the carbamoylation reactions."
07/01/1971 - "Inhibition of growth of Ehrlich ascites tumors in ICR-Ha Swiss mice by isocyanates."

04/01/2013 - "The objective of this present study was to describe the clinical-radiological and lung function characteristics of hypersensitivity pneumonitis due to exposure to isocyanates (HPI). "
04/01/2013 - "Hypersensitivity pneumonitis due to isocyanates: lung function, clinical and radiological characteristics."
05/01/2002 - "Chronic exposure to isocyanates also induces hypersensitivity pneumonitis (HP). "
07/01/2001 - "This article deals with the case reports of hypersensitivity pneumonitis (HP) induced by isocyanates in Japan. "
07/01/2001 - "Occupational hypersensitivity pneumonitis due to isocyanates: mechanisms of action and case reports in Japan."

03/01/2005 - "Previous studies have demonstrated that dermal exposure to isocyanates in mice results in systemic sensitization that leads to eosinophilic airways inflammation upon subsequent airway challenge. "
06/01/2014 - "Increased eNO levels may indicate increased airway inflammation in atopic, non-smokers exposed to isocyanates especially at higher levels of isocyanate exposure."
01/01/2009 - "The isocyanates induced inflammation, resulting in extensive DNA damage, evidenced by increases in ATM, ATR, gammaH2AX, and p53 expression levels. "
11/01/2008 - "Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytes."
10/01/2002 - "Airway inflammation and functional changes after exposure to different concentrations of isocyanates."

03/01/1992 - "A 68-year-old male developed dry cough and exertional dyspnea after handling paint spray containing isocyanates (TDI, MDI) for three months. "
10/01/1991 - "[Laryngeal dyspnea and hypersensitivity to isocyanates]."
05/01/1995 - "Each of the 14 study patients who had hypersensitivity pneumonitis had work-related dyspnea and fever occurring several hours after the start of work with isocyanates. "
04/01/1996 - "A 31-year-old machinist experienced acute symptoms of rhinoconjunctivitis, coughing, shortness of breath, and wheezing after sudden exposure to fumes containing isocyanates and solvents. "