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Sodium-Hydrogen Antiporter

Subscribe to New Research on Sodium-Hydrogen Antiporter

A plasma membrane exchange glycoprotein transporter that functions in intracellular pH regulation, cell volume regulation, and cellular response to many different hormones and mitogens.

Also Known As:

Sodium-Hydrogen Exchanger; Sodium-Proton Antiporter; Antiporter, Sodium-Hydrogen; Antiporter, Sodium-Proton; Exchanger, Sodium-Hydrogen; Sodium Hydrogen Antiporter; Sodium Hydrogen Exchanger; Sodium Proton Antiporter; Na(+)-H(+)-Antiporter; Na(+)-H(+)-Exchanger

Networked: 450 relevant articles (19 outcomes, 63 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Carrier Proteins: 11456
    - Membrane Transport Proteins: 165
      - Ion Pumps: 30
        Antiporters: 21
        Sodium-Hydrogen Antiporter: 450
        sodium-hydrogen exchanger regulatory factor: 23
        sodium-hydrogen exchanger 3: 12
        growth factor-activatable Na-H exchanger NHE-1: 5
        Arabidopsis CHX17 protein
        Arabidopsis CHX21 protein
        Arabidopsis NHX1 protein
        Arabidopsis NHX4 protein
        Arabidopsis SOS1 protein
        C elegans nhx-1 protein
        C elegans NHX-2 protein
        C elegans PBO-4 protein
        C elegans PBO-5 protein
        Candida albicans CNH1 protein
        E coli NhaA protein
        E coli NhaB protein
        human NHEDC1 protein
        human SLC9A1 protein
        human SLC9A2 protein
        human SLC9A6 protein
        human SLC9A7 protein
        human SLC9A8 protein
        human SLC9A9 protein
        mouse NHE protein
        mouse NHE6 protein
        mouse NHE9 protein
        mouse Slc9a1 protein
        mouse Slc9a2 protein
        mouse Slc9a4 protein
        mouse Slc9a8 protein
        Pseudomonas aeruginosa NhaP protein
        rat NHE8 protein
        rat Slc9a1 protein
        rat Slc9a2 protein
        rat Slc9a4 protein
        S cerevisiae NHA1 protein
        S cerevisiae NHX1 protein
        S cerevisiae Vnx1 protein
        S pombe Sod2 protein
        sodium-hydrogen exchanger 5
        Vibrio NhaD protein
        Zygosaccharomyces rouxii SOD2 protein
  - Membrane Proteins: 5300
    - Membrane Glycoproteins: 1848
      - Antiporters: 21
        Sodium-Hydrogen Antiporter: 450
        sodium-hydrogen exchanger regulatory factor: 23
        sodium-hydrogen exchanger 3: 12
        growth factor-activatable Na-H exchanger NHE-1: 5
        Arabidopsis CHX17 protein
        Arabidopsis CHX21 protein
        Arabidopsis NHX1 protein
        Arabidopsis NHX4 protein
        Arabidopsis SOS1 protein
        C elegans nhx-1 protein
        C elegans NHX-2 protein
        C elegans PBO-4 protein
        C elegans PBO-5 protein
        Candida albicans CNH1 protein
        E coli NhaA protein
        E coli NhaB protein
        human NHEDC1 protein
        human SLC9A1 protein
        human SLC9A2 protein
        human SLC9A6 protein
        human SLC9A7 protein
        human SLC9A8 protein
        human SLC9A9 protein
        mouse NHE protein
        mouse NHE6 protein
        mouse NHE9 protein
        mouse Slc9a1 protein
        mouse Slc9a2 protein
        mouse Slc9a4 protein
        mouse Slc9a8 protein
        Pseudomonas aeruginosa NhaP protein
        rat NHE8 protein
        rat Slc9a1 protein
        rat Slc9a2 protein
        rat Slc9a4 protein
        S cerevisiae NHA1 protein
        S cerevisiae NHX1 protein
        S cerevisiae Vnx1 protein
        S pombe Sod2 protein
        sodium-hydrogen exchanger 5
        Vibrio NhaD protein
        Zygosaccharomyces rouxii SOD2 protein
    - Membrane Transport Proteins: 165
      - Ion Pumps: 30
        Antiporters: 21
        Sodium-Hydrogen Antiporter: 450
        sodium-hydrogen exchanger regulatory factor: 23
        sodium-hydrogen exchanger 3: 12
        growth factor-activatable Na-H exchanger NHE-1: 5
        Arabidopsis CHX17 protein
        Arabidopsis CHX21 protein
        Arabidopsis NHX1 protein
        Arabidopsis NHX4 protein
        Arabidopsis SOS1 protein
        C elegans nhx-1 protein
        C elegans NHX-2 protein
        C elegans PBO-4 protein
        C elegans PBO-5 protein
        Candida albicans CNH1 protein
        E coli NhaA protein
        E coli NhaB protein
        human NHEDC1 protein
        human SLC9A1 protein
        human SLC9A2 protein
        human SLC9A6 protein
        human SLC9A7 protein
        human SLC9A8 protein
        human SLC9A9 protein
        mouse NHE protein
        mouse NHE6 protein
        mouse NHE9 protein
        mouse Slc9a1 protein
        mouse Slc9a2 protein
        mouse Slc9a4 protein
        mouse Slc9a8 protein
        Pseudomonas aeruginosa NhaP protein
        rat NHE8 protein
        rat Slc9a1 protein
        rat Slc9a2 protein
        rat Slc9a4 protein
        S cerevisiae NHA1 protein
        S cerevisiae NHX1 protein
        S cerevisiae Vnx1 protein
        S pombe Sod2 protein
        sodium-hydrogen exchanger 5
        Vibrio NhaD protein
        Zygosaccharomyces rouxii SOD2 protein

Experts

1.	Karmazyn, Morris: 9 articles (12/2014 - 04/2002)
2.	Fliegel, Larry: 9 articles (09/2012 - 03/2007)
3.	Mraiche, Fatima: 7 articles (06/2015 - 05/2007)
4.	Wu, Dongmei: 7 articles (08/2014 - 06/2009)
5.	McDonough, Alicia A: 7 articles (07/2012 - 11/2002)
6.	Cingolani, Horacio E: 6 articles (05/2015 - 03/2002)
7.	Casavola, Valeria: 6 articles (02/2015 - 10/2005)
8.	Reshkin, Stephan J: 6 articles (11/2013 - 10/2005)
9.	Gazmuri, Raúl J: 6 articles (02/2011 - 04/2002)
10.	Ayoub, Iyad M: 6 articles (02/2011 - 04/2002)

Related Diseases

1.	Ischemia 11/01/2003 - "By 30 minutes of reperfusion, regional end-systolic pressure-dimension relation decreased further in the ischemia and reperfusion-only group (1.6 +/- 0.2, P <.05), but improved with Na(+)/H(+) exchanger inhibition (4.4 +/- 0.7, P <.05). " 02/01/2009 - "Sarcolemmal Na(+)/H(+) exchanger (NHE) activity, which is provided by the NHE isoform 1 (NHE1), has been implicated in ischemia/reperfusion-induced myocardial injury in animal models and humans, on the basis of studies with pharmacological NHE1 inhibitors. " 04/15/2015 - "Ischemic preconditioning inhibits expression of Na(+)/H(+) exchanger 1 (NHE1) in the gerbil hippocampal CA1 region after transient forebrain ischemia." 01/05/2013 - "Following ischemia, a cascade of deleterious events including over-activity of Na(+)-H(+) Exchanger (NHE) takes place. " 01/01/2012 - "A higher increase in intracellular Na(+) via Na(+)/H(+) exchanger (NHE) during ischemia has been reported in type 2 diabetic mouse hearts. "
2.	Reperfusion Injury 04/01/2008 - "The findings suggest that sodium hydrogen exchanger isoform-1 inhibition holds promise for a new class of drugs that could significantly reduce myocardial injury associated with ischemia-reperfusion injury." 01/01/2014 - "Activation of the Na(+)/H(+) exchanger (NHE) at the time of reperfusion plays an important role in ischemia-reperfusion injury. " 11/01/2011 - "On the other hand, Na(+)/H(+) exchanger (NHE)-1 inhibitor has been demonstrated to exert beneficial effects in ischemic-reperfusion injury and in the development of cardiac remodeling. " 07/01/2010 - "Current strategies to ameliorate cardiac ischaemic and reperfusion damage, including block of the sodium-hydrogen exchanger, are therapeutically ineffective. " 02/01/2008 - "Selective inhibition of Na(+)/H(+) exchanger (NHE) improves organ dysfunctions including heart ischemia-reperfusion injury. "
3.	Ventricular Fibrillation 04/01/2002 - "Myocardial protection during ventricular fibrillation by inhibition of the sodium-hydrogen exchanger isoform-1." 05/19/2000 - "Inhibition of the Na(+)/H(+) exchanger attenuates phase 1b ischemic arrhythmias and reperfusion-induced ventricular fibrillation." 12/01/2015 - "The Na(+)/H(+) exchanger inhibitor EIPA attenuated the electrophysiological effects responsible for the acceleration and increased complexity of ventricular fibrillation induced by acute myocardial stretch. " 10/01/2007 - "To investigate whether sodium-hydrogen exchanger isoform-1 (NHE-1) inhibition attenuates myocardial injury during resuscitation from ventricular fibrillation through effects on energy metabolism, using an open-chest pig model in which coronary perfusion was controlled by extracorporeal circulation. " 04/01/2009 - "We now investigated the role of caspase-3 activation by examining whether such process prompts apoptotic DNA fragmentation, whether caspase-3 inhibition attenuates myocardial dysfunction, and whether myocardial protective effects of sodium-hydrogen exchanger isoform-1 (NHE-1) inhibition involve caspase-3 inhibition using a rat model of ventricular fibrillation (VF) of closed-chest resuscitation. "
4.	Acidosis 10/01/1996 - "These studies demonstrate that the increase in Na/H antiporter activity seen in metabolic acidosis involves an increase in NHE3 protein abundance, which is distributed along the proximal tubule and the thick ascending limb. " 01/01/2013 - "We hypothesized that targeting pH-regulatory protein, Na(+)/H(+) exchanger (NHE1) could be a novel approach for the treatment of acute metabolic acidosis. " 11/01/2010 - "In conclusion, the neonatal proximal tubule can adapt to metabolic acidosis with an increase in Na(+)/H(+) exchanger activity." 11/01/2010 - "Proximal convoluted tubule Na(+)/H(+) exchanger activity (dpH(i)/dt) was 1.68 ± 0.19 pH units/min in control tubules and 2.49 ± 0.60 pH units/min in acidemic neonatal mice (P < 0.05), indicating that the neonatal proximal tubule can respond to metabolic acidosis with an increase in Na(+)/H(+) exchanger activity. " 07/01/2010 - "The Na(+)/H(+) exchanger (NHE-1) plays a key role in pH(i) recovery from acidosis and is regulated by pH(i) and the ERK1/2-dependent phosphorylation pathway. "
5.	Heart Failure 04/19/2002 - "In this study, we have identified the cardiac Na(+)-H(+) exchanger (NHE1) as a novel mediator of adrenergically induced heart failure. " 12/01/2014 - "Na(+)/H(+) exchanger 1 (NHE-1) inhibition attenuates the hypertrophic response and heart failure in various experimental models. " 11/01/2006 - "At all stimulation frequencies, Na(+)/H(+) exchanger inhibition reduced pH(i) by 0.05 pH units (P < or = 0.01) and contractility by 22% (P < or = 0.05) in cardiomyocytes from the heart failure group. " 01/01/2005 - "Less Na+/H+-exchanger to treat heart failure: a simple solution for a complex problem?" 10/10/2008 - "Activation of the sarcolemmal Na(+)/H(+) exchanger (NHE)1 is increasingly documented as a process involved in cardiac hypertrophy and heart failure. "

Related Drugs and Biologics

1.	Amiloride (Midamor)
2.	cariporide
3.	Glucose (Dextrose)
4.	sabiporide
5.	(1- (quinolin- 5- yl)- 5- cyclopropyl- 1H- pyrazole- 4- carbonyl)guanidine
6.	Caspase 3 (Caspase-3)
7.	Sirolimus (Rapamycin)
8.	Glutamate-Ammonia Ligase (Glutamine Synthetase)
9.	Sodium-Calcium Exchanger
10.	Sodium

Related Therapies and Procedures

1.	Resuscitation
2.	Cardiopulmonary Bypass (Heart-Lung Bypass)
3.	Deep Hypothermia Induced Circulatory Arrest
4.	Transplants (Transplant)
5.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)