Ossification of Posterior Longitudinal Ligament

A calcification of the posterior longitudinal ligament of the spinal column, usually at the level of the cervical spine. It is often associated with anterior ankylosing hyperostosis.

Also Known As:

Networked: 36 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Osteophyte
2.	Intervertebral Disk Displacement (Herniated Disc)
3.	Spinal Cord Diseases
4.	Spondylosis
5.	Paraplegia (Spastic Paraplegia)

Experts

1.	Chen, Yu: 3 articles (08/2009 - 10/2007)
2.	Shimizu, Katsuji: 2 articles (09/2011 - 06/2002)
3.	Yamashita, Koichi: 2 articles (12/2009 - 11/2008)
4.	Yokoyama, Takeshi: 2 articles (12/2009 - 11/2008)
5.	Chen, Deyu: 2 articles (08/2009 - 10/2007)
6.	Wang, Xinwei: 2 articles (08/2009 - 10/2007)
7.	Yuan, Wen: 2 articles (08/2009 - 04/2009)
8.	Denaro, Luca: 1 article (11/2015)
9.	Salvatore, Giuseppe: 1 article (11/2015)
10.	Longo, Umile Giuseppe: 1 article (11/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ossification of Posterior Longitudinal Ligament:

1.	Biological Markers (Surrogate Marker)IBA 04/01/2000 - "The efficacy of biochemical markers in patients with ossification of posterior longitudinal ligament of the spine." 01/01/2015 - "To identify putative biomarkers for ossification of posterior longitudinal ligament (OPLL). " 08/15/2003 - "This work was performed to investigate the role of vitamin K (VK) in the pathogenesis of ossification of posterior longitudinal ligament (OPLL), by analyzing the biochemical markers of the blood samples of OPLL patients and responses of ligament cells derived from OPLL lesion to VK2. "
2.	Leptin ReceptorsIBA 04/15/2005 - "The extent of ossification of posterior longitudinal ligament of the spine associated with nucleotide pyrophosphatase gene and leptin receptor gene polymorphisms."
3.	Collagen Type I (Type I Collagen)IBA 04/01/2000 - "Serum levels of carboxyterminal propeptide of type I collagen (PICP), osteocalcin (OC), carboxyterminal telopeptide of type I collagen (ICTP) and urinary levels of pyridinoline (Pyr) and deoxypyridinoline (Dpyr) were measured in patients with ossification of posterior longitudinal ligament of the spine (OPLL) and age-matched control subjects. "
4.	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 10/01/2012 - "[Research progress of bone morphogenetic protein and liability of ossification of posterior longitudinal ligament]."
5.	OsteocalcinIBA 04/01/2000 - "Serum levels of carboxyterminal propeptide of type I collagen (PICP), osteocalcin (OC), carboxyterminal telopeptide of type I collagen (ICTP) and urinary levels of pyridinoline (Pyr) and deoxypyridinoline (Dpyr) were measured in patients with ossification of posterior longitudinal ligament of the spine (OPLL) and age-matched control subjects. "
6.	Isotretinoin (Accutane)FDA LinkGeneric 01/01/1985 - "Two patients are described who developed posterior longitudinal ligament ossification following treatment with the synthetic retinoid 13-cis-retinoic acid. "
7.	Vitamin KFDA Link 08/15/2003 - "This work was performed to investigate the role of vitamin K (VK) in the pathogenesis of ossification of posterior longitudinal ligament (OPLL), by analyzing the biochemical markers of the blood samples of OPLL patients and responses of ligament cells derived from OPLL lesion to VK2. "
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/15/1996 - "Restriction fragment length polymorphism of genes of the alpha 2(XI) collagen, bone morphogenetic protein-2, alkaline phosphatase, and tumor necrosis factor-alpha among patients with ossification of posterior longitudinal ligament and controls from the Japanese population."
9.	Insulin (Novolin)FDA Link 06/01/2008 - "Non-insulin-dependent diabetes is known as a risk factor of ossification of posterior longitudinal ligament, but the mechanism has not been well understood. "
10.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 05/01/2015 - "Mead acid (20:3n-9) and n-3 polyunsaturated fatty acids are not associated with risk of posterior longitudinal ligament ossification: results of a case-control study."

Therapies and Procedures

1.	Decompression 05/15/2008 - "This study examined the clinical outcomes of circumferential spinal cord decompression through a posterior approach for thoracic ossification of posterior longitudinal ligament (OPLL), to determine the efficacy of this procedure and the incidence of complications. " 12/01/2012 - "[The analysis of prognostic factors in patients with thoracic ossification of the ligamentum flavum and thoracic ossification of posterior longitudinal ligament by posterior decompression]." 06/01/2012 - "Management of cerebrospinal fluid leakage after anterior decompression for ossification of posterior longitudinal ligament in the thoracic spine: the utilization of a volume-controlled pseudomeningocele." 10/01/2009 - "Surgical outcome of anterior decompression and fusion for the ossification of posterior longitudinal ligament of the cervical spine : a comparison with laminoplasty]." 09/15/2008 - "[The strategy of posterior decompression and re-establishing the insertion of extensor for ossification of posterior longitudinal ligament involved in C(2)]."
2.	Laminectomy 08/01/2011 - "All comparison studies are retrospective cohort studies, comparing surgical outcomes of anterior approach (corpectomy and fusion) with that of posterior approach (laminoplasty or laminectomy) for the treatment of multilevel ossification of posterior longitudinal ligament in the cervical spine. " 11/01/2015 - "Bibliographic databases were searched using the following keywords: spinal cord drift, spinal cord shift, CSM, ossification of posterior longitudinal ligament, posterior decompression, laminoplasty, laminectomy and fusion. " 10/01/2007 - "To investigate the imaging findings correlated with C5 root palsies in the patients undergoing laminectomy and lateral mass screw fixation for ossification of posterior longitudinal ligament (OPLL), and clarify its pathogenic mechanism. " 10/01/2007 - "C5 palsy after laminectomy and posterior cervical fixation for ossification of posterior longitudinal ligament."
3.	Transplants (Transplant) 09/01/2011 - "Six patients, who had been treated by laminoplasty for cervical spondylotic myelopathy (n = 2) or ossification of posterior longitudinal ligament (OPLL, n = 4) and had unfavorable outcomes, underwent ACDF using autogenous fibular strut grafts. " 01/15/2003 - "A retrospective analysis of graft and plate complications after multilevel anterior cervical corpectomy and fusion (ACF) attributed to spondylosis, stenosis, and ossification of posterior longitudinal ligament was conducted. "
4.	Spinal Fusion (Spondylosyndesis) 03/01/2013 - "A 60-year-old man underwent posterior spinal fusion due to ossification of posterior longitudinal ligament, but postoperative computed tomography scans of the chest demonstrated a compression of the posterior wall of the thoracic aorta by the pedicle screw at T10. " 12/01/2009 - "We experienced a case of submucosal hematoma of the esophagus noticed after cervical anterior spinal fusion (ASF) between C7 and T1 for ossification of posterior longitudinal ligament (OPLL). "
5.	Spinal Manipulation 03/01/2010 - "Cervical intradural disc herniation after spinal manipulation therapy in a patient with ossification of posterior longitudinal ligament: a case report and review of the literature."