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Calcium-Calmodulin-Dependent Protein Kinases

Subscribe to New Research on Calcium-Calmodulin-Dependent Protein Kinases

A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also sometimes dependent on CALCIUM. A wide range of proteins can act as acceptor, including VIMENTIN; SYNAPSINS; GLYCOGEN SYNTHASE; MYOSIN LIGHT CHAINS; and the MICROTUBULE-ASSOCIATED PROTEINS. (From Enzyme Nomenclature, 1992, p277)

Also Known As:

Calcium-Calmodulin-Dependent Protein Kinases, Multifunctional; Calcium-Calmodulin-Dependent Protein Kinases, Restricted; Calmodulin-Dependent Multiprotein Kinase; Calmodulin-Kinase; Cam-MPK; Multifunctional Calcium-Calmodulin-Dependent Protein Kinases; Restricted Calcium-Calmodulin-Dependent Protein Kinases; Calcium Calmodulin Dependent Protein Kinases, Multifunctional; Calcium Calmodulin Dependent Protein Kinases, Restricted; Calmodulin Dependent Multiprotein Kinase; Calmodulin Dependent Protein Kinases; Calmodulin Kinase; Multifunctional Calcium Calmodulin Dependent Protein Kinases; Multiprotein Kinase, Calmodulin-Dependent; Protein Kinases, Calcium-Calmodulin-Dependent; Protein Kinases, Calmodulin-Dependent; Restricted Calcium Calmodulin Dependent Protein Kinases; Ca(2+)-Calmodulin-Dependent Protein Kinase; Calmodulin-Dependent Protein Kinases

Networked: 215 relevant articles (3 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Anderson, Mark E: 20 articles (01/2016 - 09/2002)
2.	Maier, Lars S: 9 articles (12/2014 - 12/2006)
3.	Luczak, Elizabeth D: 8 articles (02/2014 - 03/2010)
4.	Mattiazzi, Alicia: 7 articles (01/2016 - 01/2002)
5.	Mohler, Peter J: 7 articles (07/2013 - 09/2007)
6.	Bers, Donald M: 6 articles (05/2015 - 12/2006)
7.	Wehrens, Xander H T: 6 articles (09/2014 - 07/2009)
8.	Valverde, Carlos A: 5 articles (01/2016 - 06/2010)
9.	Sossalla, Samuel: 5 articles (12/2014 - 10/2010)
10.	Grumbach, Isabella M: 5 articles (02/2014 - 02/2010)

Related Diseases

1.	Heart Failure 10/29/2010 - "Heart failure (HF) is known to be associated with increased Ca(2+)/calmodulin-dependent protein kinase (CaMK)II expression and activity. " 03/17/2000 - "Sarcoplasmic reticulum Ca(2+)/Calmodulin-dependent protein kinase is altered in heart failure." 08/01/2010 - "Cardiac Ca(2+)/calmodulin-dependent protein kinase (CaMK) IIdelta expression and activity are altered in cardiac hypertrophy and heart failure. " 04/11/2014 - "Although the RyR is involved in heart failure-related Ca(2+) disturbances, this results from Ca(2+)-calmodulin kinase II and reactive oxygen species-mediated regulation rather than by RyR2808 phosphorylation. " 03/15/2014 - "Ca(2+)-calmodulin-dependent protein kinase II (CaMKII) hyperactivity in heart failure causes intracellular Na(+) ([Na(+)]i) loading (at least in part by enhancing the late Na(+) current). "
2.	Ischemia 05/01/1995 - "Ca2+/calmodulin kinase II translocates in a hippocampal slice model of ischemia." 09/01/2007 - "Mice with genetic inhibition (AC3-I) of the multifunctional Ca(2+)/calmodulin dependent protein kinase II (CaMKII) have improved cardiomyocyte survival after ischemia. " 11/01/2015 - "Live imaging of endogenous Ca(2+) /calmodulin-dependent protein kinase II in neurons reveals that ischemia-related aggregation does not require kinase activity." 09/01/2014 - "Ca(2+)-calmodulin kinase II (CaMKII) activation is deleterious in cardiac ischemia/reperfusion (I/R). " 03/01/2014 - "While Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) has been suggested to be an important protein regulating heart function upon ischemia/reperfusion (I/R), the mechanisms responsible are not fully known. "
3.	Heart Diseases (Heart Disease) 12/01/2005 - "Calmodulin kinase II as a target for inhibition in cardiac disease." 04/01/2005 - "Calmodulin kinase II inhibition protects against structural heart disease." 06/01/2012 - "The objective of this study was to establish whether 1) hyperactivity of renin-angiotensin-aldosterone system (RAAS) produces apoptosis in early stages of cardiac disease; and 2) Ca(2+)-calmodulin-dependent protein kinase II (CaMKII) is involved in these apoptotic events. " 01/01/2016 - "Although multifunctional Ca(2+) calmodulin-dependent protein kinase II (CaMKII) is ROS-activated and CaMKII hyperactivity promotes cardiac diseases, a link between prediabetes and CaMKII in the heart is unprecedented. " 01/01/2013 - "This review evaluates recent advances in mechanisms underlying aldosterone-induced cardiac disease and highlights the interplay between aldosterone and Ca(2+)/calmodulin dependent protein kinase II, whose hyperactivity during heart failure contributes to disease progression. "
4.	Body Weight (Weight, Body) 09/01/2010 - "Comparing with young and aged unimpaired animals, aged impaired rats exhibited significant reduction in hippocampal but not cortical cAMP-response element-binding phosphorylation states as well as brain-derived neurotrophic factor messenger RNA and protein expressions, which were accompanied by decreased phosphorylation states of hippocampal extracellular signal-related kinase (42/44) and calcium calmodulin kinase IV. Lotus seedpod supplementation (50 and 100 mg/kg body weight intragastric administration) for 7 weeks significantly reversed all these declines happened in hippocampus except calcium calmodulin kinase IV phosphorylation levels. "
5.	Anoxia (Hypoxia) 08/08/2008 - "Previously we showed that following hypoxia there is an increase in nuclear Ca(2+)-influx and Ca(2+)/calmodulin-dependent protein kinase IV activity (CaMK IV) in the cerebral cortex of term guinea pig fetus. " 03/15/2004 - "The induction of TPI gene expression by hypoxia was suppressed by (1) a chelator of intracellular Ca(2+), (2) a blocker of non-selective cation channels, (3) a blocker of Na(+)/Ca(2+) exchangers, (4) an inhibitor of Ca(2+)/calmodulin-dependent protein kinases, and (5) an inhibitor of c-jun/AP-1 activation." 11/01/1999 - "To study the effect of dopamine receptor antagonists on anoxia-induced inhibition of Ca(2+)-calmodulin dependent protein kinase II (CCDPK II) activity in rat hippocampus and striatum. " 11/01/2014 - "Moreover, when the levels of [Ca(2+)]i were increased by hypoxia, H-89, but not KN93, (a calmodulin kinase II inhibitor), prevented the reduction in [Ca(2+)]i by TNFα. " 01/01/2014 - "Previously, we have demonstrated in the newborn piglet that within one hour of exposure to hypoxia, there is increased activation of the enzyme Ca++/calmodulin kinase (CaM Kinase) IV localized in the nucleus, a key regulator of transcription of apoptotic genes. "

Related Drugs and Biologics

1.	Calcium-Calmodulin-Dependent Protein Kinase Type 2
2.	Calcium
3.	Phosphotransferases (Kinase)
4.	Protein Kinases (Protein Kinase)
5.	Protein Kinase C
6.	Mitogen-Activated Protein Kinase 3
7.	Messenger RNA (mRNA)
8.	Brain-Derived Neurotrophic Factor (BDNF)
9.	protein kinase D
10.	G-Protein-Coupled Receptor Kinase 2

Related Therapies and Procedures

1.	Catheters
2.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
3.	Microspheres (Microsphere)