Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)

A group of cyclic GMP-dependent enzymes that catalyze the phosphorylation of SERINE or THREONINE residues of proteins.

Also Known As:

Protein Kinase G; cGMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinase; G-Kinase; G-Kinases; Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase; Cyclic GMP Dependent Protein Kinase; Cyclic GMP Dependent Protein Kinases; G Kinase; G Kinases; Guanosine Cyclic 3',5' Phosphate Dependent Protein Kinase; Guanosine Cyclic Monophosphate Dependent Protein Kinase; Guanosine Cyclic Monophosphate Dependent Protein Kinases; Kinase, cGMP-Dependent Protein; Kinases, cGMP-Dependent Protein; Protein Kinase, cGMP-Dependent; Protein Kinases, cGMP-Dependent; cGMP Dependent Protein Kinase; cGMP Dependent Protein Kinases; Guanosine Cyclic Monophosphate-Dependent Protein Kinase; Guanosine Cyclic Monophosphate-Dependent Protein Kinases; cGMP-Dependent Protein Kinase

Networked: 419 relevant articles (14 outcomes, 50 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kass, David A: 12 articles (01/2022 - 11/2007)
2.	Baker, David A: 12 articles (01/2021 - 06/2008)
3.	Chen, Yongchang: 11 articles (05/2022 - 02/2012)
4.	Qian, Hai: 8 articles (05/2022 - 11/2012)
5.	Jiang, Lu: 8 articles (01/2018 - 06/2012)
6.	Tao, Yan: 8 articles (01/2018 - 03/2010)
7.	Wang, Ying: 8 articles (01/2018 - 06/2012)
8.	Lan, Ting: 8 articles (04/2014 - 02/2012)
9.	Raj, J Usha: 8 articles (03/2012 - 02/2007)
10.	Wu, Yan: 7 articles (05/2022 - 02/2012)

Related Diseases

1.	Reperfusion Injury 08/01/2013 - "It is well known that cyclic guanosine 3',5'-monophosphate plays an important role in cardioprotection against ischemia/reperfusion injury through activation of protein kinase G (PKG). " 12/12/2017 - "The nitric oxide-sensitive guanylyl cyclase/cGMP-dependent protein kinase type I signaling pathway can afford protection against the ischemia/reperfusion injury that occurs during myocardial infarction. " 08/01/2023 - "sGC stimulation in RBCs from patients with type 2 diabetes increased export of cyclic guanosine monophosphate from RBCs and activated cardiac protein kinase G, thereby attenuating ischemia-reperfusion injury. " 01/01/2018 - "The nitric oxide (NO)-protein kinase G (PKG) pathway has been known for some time to be an important target for cardioprotection against ischaemia/reperfusion injury and heart failure. " 01/01/2013 - "Stimulation of the nitric oxide (NO)--soluble guanylate (sGC)--protein kinase G (PKG) pathway confers protection against acute ischaemia/reperfusion injury, but more chronic effects in reducing post-myocardial infarction (MI) heart failure are less defined. "
2.	Heart Failure 11/01/2015 - "Pharmacological activation of cGMP-dependent protein kinase G I (PKGI) has emerged as a therapeutic strategy for humans with heart failure. " 11/01/2013 - "Protein kinase G I and heart failure: Shifting focus from vascular unloading to direct myocardial antiremodeling effects." 08/14/2012 - "Low myocardial protein kinase G activity in heart failure with preserved ejection fraction." 11/26/2007 - "In disorders such as cardiac failure, PDE5A upregulation may contribute to a decline in cGMP and protein kinase G signaling, exacerbating dysfunction. " 01/01/2022 - "Phosphodiesterase 5 inhibition (PDE5i) activates cGMP-dependent protein kinase (PKG) and ameliorates heart failure; however, its impact on cardiac mitochondrial regulation has not been fully determined. "
3.	Ischemia 12/15/2006 - "Cyclic GMP-dependent protein kinase Ialpha attenuates necrosis and apoptosis following ischemia/reoxygenation in adult cardiomyocyte." 09/01/1993 - "Understanding the involvement of PKC, PKA, and the cGMP-dependent protein kinase in modulating the effect of neuronal death during ischemia and NO toxicity may help in directing future therapeutic modalities for cerebrovascular disease." 12/12/2017 - "Reportedly, voltage and Ca2+-activated K+ channels of the BK type are stimulated by cGMP/cGMP-dependent protein kinase type I, and recent ex vivo studies implicated that increased BK activity favors the survival of the myocardium at ischemia/reperfusion. " 07/01/2010 - "Our results suggest that PDE5 inhibition enhances ischemia-induced angiogenesis with mobilization of EPCs through a protein kinase G-dependent HIF-1/vascular endothelial growth factor pathway. " 12/15/2004 - "Thus, NO prevents pH-dependent cell killing after ischemia/reperfusion by a guanylyl cyclase/cGMP/protein kinase G signaling cascade that blocks the MPT."
4.	Myocardial Infarction 12/12/2017 - "The nitric oxide-sensitive guanylyl cyclase/cGMP-dependent protein kinase type I signaling pathway can afford protection against the ischemia/reperfusion injury that occurs during myocardial infarction. " 01/01/2018 - "Nitric oxide-sensitive guanylate cyclase/cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein kinase type I-signaling pathway protects against the IR injury during myocardial infarction. " 01/01/2013 - "Stimulation of the nitric oxide (NO)--soluble guanylate (sGC)--protein kinase G (PKG) pathway confers protection against acute ischaemia/reperfusion injury, but more chronic effects in reducing post-myocardial infarction (MI) heart failure are less defined. "
5.	Hypoxia (Hypoxemia) 03/01/2007 - "In the present study, we determined the role of ROCKs in cGMP-dependent protein kinase (PKG)-mediated pulmonary vasodilation of fetal lambs exposed to chronic hypoxia. " 10/01/2019 - "Future Directions: The regulation and impact of hypoxia-inducible factor and the function of cGMP-dependent and redox regulation of protein kinase G are considered for their potential roles as key sensors and coordinators of redox and metabolic processes controlling the progression of vascular pathophysiology in PH, and how modulating aspects of metabolic and redox regulatory systems potentially function in beneficial therapeutic approaches." 12/01/2011 - "Roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia." 10/01/2011 - "We have shown previously that acute hypoxia downregulates protein kinase G (PKG) expression and activity in ovine fetal pulmonary vessels and pulmonary arterial smooth muscle cells (SMC). " 07/01/2009 - "We previously showed that acute hypoxia decreases cGMP-dependent protein kinase (PKG) activity in PVSMC and that PKG plays a role in maintaining the differentiated contractile phenotype in normoxia. "

Related Drugs and Biologics

1.	Guanosine Monophosphate (5' Guanylic Acid)
2.	Soluble Guanylyl Cyclase
3.	Type 5 Cyclic Nucleotide Phosphodiesterases
4.	Nitric Oxide (Nitrogen Monoxide)
5.	Nitric Oxide Synthase (NO Synthase)
6.	sulindac sulfone (exisulind)
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8.	Sildenafil Citrate (Viagra)
9.	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)
10.	BAY 58-2667

Related Therapies and Procedures

1.	Electroacupuncture
2.	Therapeutics
3.	Intraventricular Infusions
4.	Vagus Nerve Stimulation
5.	Stents