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Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)

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A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.

Also Known As:

cAMP-Dependent Protein Kinase; Protein Kinase A; Cyclic AMP-Dependent Protein Kinase; Adenosine Cyclic Monophosphate Dependent Protein Kinases; Cyclic AMP Dependent Protein Kinase; Cyclic AMP Dependent Protein Kinases; Protein Kinase, cAMP-Dependent; Protein Kinases, cAMP-Dependent; cAMP Dependent Protein Kinase; cAMP Dependent Protein Kinases; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; cAMP-Dependent Protein Kinases

Networked: 1521 relevant articles (13 outcomes, 142 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Stratakis, Constantine A: 41 articles (06/2015 - 06/2002)
2.	Kirschner, Lawrence S: 16 articles (05/2014 - 06/2002)
3.	Nesterova, Maria: 12 articles (09/2014 - 06/2002)
4.	Stratakis, C A: 10 articles (11/2014 - 05/2001)
5.	Bertherat, Jérôme: 10 articles (03/2014 - 12/2002)
6.	Cho-Chung, Yoon S: 10 articles (09/2006 - 02/2002)
7.	Groussin, Lionel: 9 articles (01/2011 - 12/2002)
8.	Levine, J D: 8 articles (10/2012 - 01/2001)
9.	Levine, Jon D: 7 articles (09/2015 - 10/2002)
10.	Ragazzon, Bruno: 7 articles (03/2014 - 10/2008)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2012 - "Since protein kinase A (PKA) is a central key component of the cAMP pathway, studies of the alterations of PKA subunits in endocrine tumors reveal new aspects of the mechanisms of cAMP pathway alterations in human diseases. " 04/01/2007 - "The present study was designed to characterize the population distribution of extracellular activity of cAMP-dependent protein kinase (ECPKA) and its potential value as a biomarker for cancer detection and monitoring of cancer therapy. " 01/01/1996 - "These cells were used to study if phosphorylation reactions by protein kinase A (PKA) and dephosphorylation reactions by protein phosphatases-1 and -2A (PP-1/2A) regulate tumor motility and adhesion to extracellular matrix components, and if this might be associated with cytoskeletal reorganization. " 10/01/1988 - "The results of this study indicate that TPA induces morphological changes in the Y-1 adrenocortical tumor cell population while increasing steroidogenesis and the activation of cAMP-dependent protein kinase and decreasing cell growth rate." 05/15/1987 - "No such microheterogeneity was noted for isozyme I. This study thus shows that the lack of cAMP-responsiveness of one tumor is related either to a defect distal to the cAMP-dependent protein kinases or to the appearance of the new subtype of RII in the resistant tumor. "
2.	Infection 04/01/2010 - "Because cAMP signaling has been implicated in regulating diverse developmental and infection processes in fungal pathogens, in this study, we aimed to elucidate the function of the cAMP-protein kinase A (PKA) pathway in toxin production and plant infection in F. " 12/01/2011 - "The cyclic AMP-dependent protein kinase A signaling pathway plays a major role in regulating plant infection by the rice blast fungus Magnaporthe oryzae. " 07/01/2010 - "Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection." 01/01/2010 - "The gene fpk1, encoding a cAMP-dependent protein kinase catalytic subunit homolog, is required for hyphal growth, spore germination, and plant infection in Fusarium verticillioides." 12/01/2008 - "The phosphorylation profile of protein kinase A substrates is modulated during Varicella-zoster virus infection."
3.	Memory Disorders (Memory Loss) 01/01/2012 - "However, mechanistic links between protein kinase A (PKA), oxidative stress and memory loss in response to Aβ remain elusive. " 03/01/2005 - "cAMP-dependent protein kinase A (PKA) signaling has a key role in memory processes and has been identified as a potential therapeutic target for memory disorders. " 03/01/2005 - "Protein kinase A as a therapeutic target for memory disorders: rationale and challenges." 05/01/1986 - "The findings suggest that in the mutant's nerve cells the state of phosphorylation of the regulatory subunit of cAMP-dependent protein kinase is altered, which may contribute to the biochemical disorder leading to the memory deficit." 01/01/2015 - "Escitalopram Ameliorates Tau Hyperphosphorylation and Spatial Memory Deficits Induced by Protein Kinase A Activation in Sprague Dawley Rats."
4.	Dyskinesias (Dyskinesia) 08/10/2012 - "We also show that mutation of the phosphorylation site for cAMP-dependent protein kinase on DARPP-32 attenuates l-DOPA-induced dyskinesia and reduces the concomitant activations of ERK and mTORC1 signaling. " 03/01/2012 - "Chronic Levodopa (L-DOPA), the gold standard therapy for Parkinson's disease (PD), causes disabling motor complications (dyskinesias) that are associated with changes in the activity of striatal protein kinase A (PKA) and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32). " 01/15/2015 - "Previous studies have implicated the cyclic adenosine monophosphate/protein kinase A pathway as well as FosB and dynorphin-B expression mediated by dopamine D1 receptor stimulation in the development of 3,4-dihydroxyphenyl-L-alanine (L-DOPA)-induced dyskinesia. " 01/01/2010 - "In rodents, the development of dyskinesia produced by L-DOPA in the dopamine-depleted striatum occurs in response to increased dopamine D1 receptor-mediated activation of the cAMP - protein kinase A and of the Ras-extracellular signal-regulated kinase (ERK) signalling pathways. "
5.	Cardiac Arrhythmias (Arrythmia) 10/01/1997 - "Drosophila melanogaster deficient in protein kinase A manifests behavior-specific arrhythmia but normal clock function." 10/23/2012 - "Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases." 10/12/2007 - "Increased phosphorylation of the cardiac ryanodine receptor (RyR)2 by protein kinase A (PKA) at the phosphoepitope encompassing Ser2808 has been advanced as a central mechanism in the pathogenesis of cardiac arrhythmias and heart failure. " 06/23/2006 - "It is suggested that protein kinase A (PKA)-dependent phosphorylation of cardiac ryanodine receptors (RyR2) is linked to the development of heart failure and the generation of fatal cardiac arrhythmias. " 01/01/2006 - "Protein kinase A (PKA) hyperphosphorylation of RyR2 in failing hearts or mutations in RyR2 linked to sudden cardiac death (SCD) can result in diastolic sarcoplasmic reticulum (SR) Ca2+ leak that can trigger fatal cardiac arrhythmias, and deplete SR Ca2+ stores contributing to decreased contractility. "

Related Drugs and Biologics

1.	Adenosine Monophosphate (AMP)
2.	Protein Kinases (Protein Kinase)
3.	Calcium
4.	Carbon Monoxide
5.	Levodopa (L Dopa)
6.	irinotecan (Camptosar)
7.	Antisense Oligonucleotides
8.	Type I DNA Topoisomerases (Topoisomerase I)
9.	protein kinase modulator
10.	phospholamban

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Castration
3.	Sutures (Suture)
4.	Spinal Injections
5.	Intradermal Injections