HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Nedocromil (Alocril)

A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.

Also Known As:

Alocril; Tilade; 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)quinoline-2,8-dicarboxylic acid; ASTA Medica Brand of Nedocromil Sodium; Allergan Brand of Nedocromil Sodium; Aventis Behring Brand of Nedocromil Sodium; Aventis Brand of Nedocromil Sodium; Brionil; Cetimil; FPL-59002; Fisons Brand of Nedocromil Sodium; Halamid; Irtan; Lesvi Brand of Nedocromil Sodium; Nedocromil Calcium; Nedocromil Sodium; Nedocromil, Calcium Salt (1:1); Nedocromil, Disodium Salt; Nedocromil, Disodium salt, Hydrate; Pantheon Brand of Nedocromil Sodium; Rapitil; Rhône-Poulenc Rorer Brand of Nedocromil Sodium; Tilad; Tilaire; Tilavist; Vita Brand of Nedocromil Sodium; Calcium, Nedocromil; FPL 59002; FPL59002; Sodium, Nedocromil; 4H-Pyrano(3,2-g)quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-

Networked: 391 relevant articles (98 outcomes, 101 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Quinolines: 92
    - Quinolones: 1190
      - 4-Quinolones: 26
        Nedocromil: 391

Experts

1.	Szefler, Stanley J: 6 articles (02/2010 - 05/2003)
2.	Weiss, Scott T: 5 articles (09/2014 - 11/2006)
3.	Childhood Asthma Management Program Research Group: 5 articles (07/2011 - 08/2004)
4.	Stelmach, Iwona: 5 articles (08/2004 - 01/2002)
5.	Kuna, Piotr: 5 articles (08/2004 - 01/2002)
6.	Strunk, Robert C: 4 articles (07/2010 - 06/2004)
7.	Zeiger, Robert S: 4 articles (07/2010 - 11/2006)
8.	Covar, Ronina A: 4 articles (02/2010 - 05/2003)
9.	Spahn, Joseph D: 4 articles (02/2010 - 05/2003)
10.	Jerzyńska, Joanna: 4 articles (03/2002 - 01/2002)

Related Diseases

1.	Asthma (Bronchial Asthma) 01/01/1986 - "Thus, nedocromil sodium is a novel drug of proven efficacy in the treatment of asthma. " 11/01/1987 - "Non-comparative and placebo-controlled therapeutic studies in adult patients of up to 52 weeks duration have demonstrated the tolerability and efficacy of nedocromil 4 mg twice or 4 times daily in the management of reversible obstructive airways disease producing significant improvements in asthma symptom scores and pulmonary function tests. " 01/01/1994 - "Nedocromil sodium is effective in improving moderate to severe asthma in addition to inhaled steroid and has some steroid sparing effect in patients treated with high dose inhaled steroid." 01/01/1994 - "The Impacts component of the St George's Respiratory Questionnaire was significantly improved in patients receiving nedocromil sodium, as were night-time asthma, asthma severity at clinic, and daytime inhaled bronchodilator use. " 08/01/1989 - "There was an improvement in symptoms in the patients taking nedocromil sodium by comparison with those having the placebo, the differences being significant for diary card PEF readings, asthma symptom scores, and bronchodilator usage at night. "
2.	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 03/01/2002 - "Nedocromil sodium 2% twice daily was effective and safe for the treatment of symptoms of allergic conjunctivitis, significantly improving quality of life and producing high rates of user and physician satisfaction." 07/01/1994 - "We conclude that nedocromil sodium, 2% ophthalmic solution, administered bid is more effective in the relief of symptoms of seasonal allergic conjunctivitis than placebo and causes no major side effects." 01/15/1992 - "We concluded that nedocromil sodium 2% ophthalmic solution administered twice daily is effective in relieving major symptoms associated with seasonal allergic conjunctivitis." 09/01/2000 - "Nedocromil sodium is effective in the management of seasonal allergic conjunctivitis." 05/01/2000 - "Nedocromil sodium 2% is an effective treatment for perennial allergic conjunctivitis. "
3.	Rhinitis 01/01/1996 - "In comparison with placebo, nedocromil sodium significantly improved rhinitis symptoms within 2 hours, and this reduction in SAR symptoms was maintained throughout the 2-day exposure period. " 05/01/1993 - "In comparison with placebo, nedocromil significantly improved rhinitis symptoms as evidenced by lower symptom summary scores within 2 hours (p = 0.016). " 12/01/1988 - "Nedocromil sodium 1% nasal spray taken four times daily was shown to be an effective treatment for grass pollen rhinitis." 03/01/1988 - "Nedocromil sodium (NS), a new pyranoquinoline dicarboxylic acid derivative, reported to be effective against both mucosal and connective tissue-type mast cells, was studied in ragweed-allergic rhinitis (RAR). " 01/01/1996 - "Relief of rhinitis symptoms is maintained throughout the peak pollen period with nedocromil sodium QID, which appears to be a safe and well tolerated treatment for ragweed SAR."
4.	Cough 03/01/1988 - "Nedocromil sodium may prove useful in the treatment of unproductive cough in situations where the use of a centrally-acting antitussive is undesirable." 12/01/2001 - "The efficacy of inhaled nedocromil sodium (NS) for children with a persistent cough was studied. " 07/01/1992 - "In 54 patients who completed the study, nedocromil sodium was significantly more efficacious than placebo (P < 0.01) in relieving morning chest-tightness and cough, in reducing total diary card score and nocturnal bronchodilator usage, and in increasing morning and evening peak flow. " 01/01/2002 - "Nedocromil sodium administration increases cough threshold and attenuates the ventilatory responses. " 12/01/2001 - "Inhaled nedocromil sodium for persistent cough in children."
5.	Exercise-Induced Asthma (Asthma, Exercise Induced) 12/01/1995 - "Our findings suggest that nedocromil sodium is effective in the prevention of exercise-induced asthma, in pediatric age." 03/01/1996 - "This open labelled, group comparative, cross over study, was carried out to analyze the efficacy of two dosages of Nedocromil sodium (NS) in the prophylaxis of Exercise Induced Asthma (EIA). " 07/01/2000 - "The Cochrane Airways Group trials register, the Cochrane Controlled Trials Register, Current Contents, reference lists of relevant articles, review articles and textbooks were searched for randomized trials comparing a single dose of nedocromil to placebo to prevent exercise-induced asthma in people >6 yrs of age. " 09/01/1995 - "In view of the high incidence of exercise-induced asthma (EIA) in asthmatic adolescents and adults, the aim of the present study was to examine the preventive effect of nedocromil sodium administered prior to an exercise provocation test. " 10/01/1989 - "Dose-response study of nebulised nedocromil sodium in exercise induced asthma."

Related Drugs and Biologics

1.	Cromolyn Sodium (Cromoglicic Acid)
2.	Bronchodilator Agents (Bronchodilators)
3.	Ophthalmic Solutions (Eye Drops)
4.	Histamine (Histamine Dihydrochloride)
5.	Nedocromil (Alocril)
6.	Adrenal Cortex Hormones (Corticosteroids)
7.	Beclomethasone (Beclometasone)
8.	Theophylline (Theon)
9.	Sodium
10.	Furosemide (Lasix)

Related Therapies and Procedures

1.	Nebulizers and Vaporizers (Inhaler)
2.	Aftercare (After-Treatment)
3.	Ambulatory Care (Outpatient Care)
4.	Lasers (Laser)
5.	Metered Dose Inhalers (Metered Dose Inhaler)