Pyogenic Granuloma

A disorder of the skin, the oral mucosa, and the gingiva, that usually presents as a solitary polypoid capillary hemangioma often resulting from trauma. It is manifested as an inflammatory response with similar characteristics to those of a granuloma.

Also Known As:

Networked: 287 relevant articles (12 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemangioma (Angioma)
2.	Wounds and Injuries (Trauma)
3.	Warts (Wart)
4.	Telangiectasis (Telangiectasia)
5.	Foreign Bodies (Foreign Body)

Experts

1.	Yuan, K: 3 articles (05/2004 - 05/2000)
2.	Lin, M T: 3 articles (05/2004 - 05/2000)
3.	Asnaashari, Mohammad: 2 articles (01/2015 - 01/2014)
4.	Azari-Marhabi, Saranaz: 2 articles (01/2015 - 01/2014)
5.	González-Pérez, Leonor V: 2 articles (12/2014 - 05/2012)
6.	Tobón-Arroyave, Sergio I: 2 articles (12/2014 - 05/2012)
7.	Isaza-Guzmán, Diana M: 2 articles (12/2014 - 05/2012)
8.	Greene, Arin K: 2 articles (03/2014 - 01/2011)
9.	Schwartz, Robert A: 2 articles (01/2014 - 06/2013)
10.	Yang, Chunjun: 2 articles (08/2013 - 08/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pyogenic Granuloma:

1.	imiquimod (Aldara)FDA LinkGeneric 07/01/2008 - "Pyogenic granuloma: complete remission under occlusive imiquimod 5% cream." 05/01/2009 - "Imiquimod is a safe, cost-effective, and clinically effective management option in the treatment of pyogenic granuloma." 05/01/2009 - "We report a series of 10 children, highlighting the safety and efficacy of topical 5% Imiquimod as an alternative noninvasive treatment of pyogenic granuloma. " 02/01/2013 - "Two pediatric cases of pyogenic granuloma treated with imiquimod 5% cream: combined clinical and dermatoscopic evaluation and review of the literature." 05/01/2009 - "Here, we present two children with pyogenic granuloma who were successfully treated by topical imiquimod cream with excellent results."
2.	monoethanolamine oleateIBA 06/01/2001 - "In this study, the efficacy of a sclerosing agent (monoethanolamine oleate) was evaluated for the treatment of pyogenic granuloma. " 06/01/2001 - "Pyogenic granuloma was treated by local injection of the monoethanolamine oleate solution in nine patients who were from 1 to 57 years of age (median 18 years). " 06/01/2001 - "Sclerotherapy with monoethanolamine oleate is effective in the treatment of pyogenic granuloma and offers an alternative to conventional methods in cases for which conservative treatment is preferable."
3.	SiliconesIBA 09/01/2007 - "Silicone implants had significantly less pre-pegging pyogenic granuloma (P = 0.011) and hypo-ophthalmos (P = 0.042) than the other implant types. " 06/01/2005 - "The authors report two cases of pyogenic granuloma secondary to silicone punctal plugs and their lacrimal sequelae following surgical removal in one case and conservative treatment with removal of the plug alone in another. " 06/01/2005 - "To report two cases of pyogenic granuloma following silicone punctal plugs. " 06/01/2005 - "Pyogenic granuloma following silicone punctal plugs: report of two cases." 04/01/2005 - "To describe clinical findings, histopathologic changes, and risk factors for pyogenic granuloma formation complicating silicone punctal plug therapy. "
4.	Timolol (Blocadren)FDA LinkGeneric 12/01/2014 - "Here we report the use of timolol 0·5% ophthalmic gel used successfully to treat a teenager with a clinically classical pyogenic granuloma on the finger. " 01/01/2015 - "Pyogenic granuloma in a 5-month-old treated with topical timolol." 12/01/2014 - "Timolol may be an effective and preferable alternative treatment to surgery for a classical small pyogenic granuloma, particularly in children and young people." 12/01/2014 - "A pyogenic granuloma treated with topical timolol." 03/01/2014 - "Resolution of recalcitrant pyogenic granuloma with laser, corticosteroid, and timolol therapy."
5.	Silver NitrateIBA 05/01/2003 - "The efficacy of silver nitrate cauterization for pyogenic granuloma of the hand." 05/01/2003 - "Pyogenic granuloma of the hand can be treated simply and effectively with silver nitrate cauterization in the office setting." 06/01/2009 - "He had previously undergone unsuccessful treatment, comprising application of liquid nitrogen and of silver nitrate to an umbilical lesion measuring several millimetres regarded as pyogenic granuloma. " 03/01/2006 - "He was diagnosed clinically as having a giant pyogenic granuloma and was given antibiotics as well as silver nitrate sticks to cauterize the wound daily. "
6.	Mitomycin (Mitomycin-C)FDA LinkGeneric 07/01/2000 - "Two (9.52%) eyes treated with intraoperative mitomycin-C had delayed epithelial healing of corneoscleral wound and one (4.76%) eye developed pyogenic granuloma. " 09/01/2006 - "To evaluate the efficacy of mitomycin C eye drops 0.02% concentration (0.02% MMC) in pyogenic granuloma in anophthalmic socket. "
7.	Penicillins (Penicillin)FDA Link 01/01/1947 - "A case of granuloma pyogenicum treated successfully with penicillin." 07/12/1947 - "Granuloma pyogenicum treated with penicillin, with recovery."
8.	Ophthalmic Solutions (Eye Drops)IBA 09/01/2006 - "[Mitomicyn C eye drops as alternative treatment for pyogenic granuloma in anophthalmic socket]." 09/01/2006 - "To evaluate the efficacy of mitomycin C eye drops 0.02% concentration (0.02% MMC) in pyogenic granuloma in anophthalmic socket. "
9.	Dental Implants (Dental Implant)IBA 10/01/2015 - "Pyogenic granuloma should be included in the differential diagnosis of soft mass growth around dental implants. " 10/01/2015 - "Clinical and histopathological diagnosis of pyogenic granuloma had been reached for soft mass growth in association with dental implants in 10 patients. " 10/01/2015 - "Patients charts were analyzed to select patients who had been diagnosed for pyogenic granuloma and its association with dental implants had been evaluated. " 10/01/2015 - "The occurrence of pyogenic granuloma in association to dental implants is rare and only five cases have been reported in the literature. " 10/01/2015 - "Pyogenic granuloma in relation to dental implants: Clinical and histopathological findings."
10.	Durapatite (Hydroxylapatite)IBA 11/01/2006 - "A clinicopathologic study of 5 patients with hydroxyapatite implants who presented with pyogenic granuloma. " 11/01/2007 - "Re: "pyogenic granuloma as a presenting sign of hydroxyapatite orbital implant exposure: a clinicopathologic study"." 11/01/2006 - "Pyogenic granuloma as a presenting sign of hydroxyapatite orbital implant exposure: a clinicopathologic study." 11/01/2006 - "Pyogenic granuloma should not be considered a benign lesion on a hydroxyapatite orbital implant, especially in recurrent cases. " 05/01/2001 - "Problems encountered with the peg were discharge in 10 (14.7%) patients, pyogenic granuloma in 9 (13.2%), conjunctiva overgrowing the peg in 4 (5.8%), hydroxyapatite exposure around the sleeve in 3 (4.4%), loose sleeve in 3 (4.4%), peg drilled on an angle in 1 (1.5%), implant infection in 1 (1.5%), and peg falling out in 1 (1.5%). "

Therapies and Procedures

1.	Cryotherapy (Therapy, Cold) 08/01/2006 - "To evaluate the efficacy of cryotherapy in the treatment of pyogenic granuloma. " 08/01/2006 - "We believe that pyogenic granuloma can be treated simply and effectively with cryotherapy." 08/01/2006 - "Cryotherapy in the treatment of pyogenic granuloma." 04/01/2006 - "Comparison of cryotherapy and curettage for the treatment of pyogenic granuloma: a randomized trial." 04/01/2006 - "To evaluate and compare the effects of cryotherapy and curettage in the treatment of pyogenic granuloma. "
2.	Curettage 04/01/2006 - "We suggest that curettage could be the first-line treatment for pyogenic granuloma." 04/01/2006 - "Comparison of cryotherapy and curettage for the treatment of pyogenic granuloma: a randomized trial." 01/01/2012 - "A 26-year-old woman was treated by curettage and cautery for a pyogenic granuloma on her left shoulder. " 04/01/2006 - "To evaluate and compare the effects of cryotherapy and curettage in the treatment of pyogenic granuloma. " 04/01/2006 - "Eighty-nine patients with pyogenic granuloma were randomized to receive cryotherapy with liquid nitrogen or curettage and electrodesiccation. "
3.	Lasers (Laser) 04/01/2014 - "The diagnosis was inflammatory lesion compatible with pyogenic granuloma and laser excision was decided. " 05/01/2011 - "Laser: a powerful tool for treatment of pyogenic granuloma." 05/01/1992 - "This preliminary report suggests that pulsed laser therapy should be considered in the treatment of pyogenic granuloma, especially in cosmetically sensitive areas." 10/01/1987 - "The laser failed to cure 2 patients with pyogenic granuloma. " 01/01/2002 - "The combined continuous-wave/pulsed CO2 laser is our treatment of choice for pyogenic granuloma because this kind of laser is widely available, produces excellent results with few adverse effects, is easy to use, yields low recurrence rates, and is well tolerated by most patients."
4.	Sclerotherapy 09/01/2014 - "Nicolau syndrome following sclerotherapy for pyogenic granuloma." 01/01/2013 - "Sclerotherapy for the treatment of pyogenic granuloma." 08/01/2014 - "Sclerotherapy: a novel bloodless approach to treat recurrent oral pyogenic granuloma associated with port-wine stain." 06/01/2001 - "Sclerotherapy with monoethanolamine oleate is effective in the treatment of pyogenic granuloma and offers an alternative to conventional methods in cases for which conservative treatment is preferable." 06/01/2013 - "Sclerotherapy with sodium tetra decyl sulphate is a relatively simple and effective method for treating oral pyogenic granuloma."
5.	Dye Lasers 08/01/2010 - "Pyogenic granuloma-treatment by shave-excision and/or pulsed-dye laser." 02/01/2006 - "We successfully treated a 1 cm periungual fingertip pyogenic granuloma with a dye laser." 02/01/2006 - "[Dye laser treatment of periungual pyogenic granuloma]." 03/01/1997 - "Treatment of pyogenic granuloma in children with the flashlamp-pumped pulsed dye laser." 01/01/1994 - "Granuloma pyogenicum as a complication of flashlamp-pumped pulsed dye laser."