CD30 Antigens

A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

Also Known As:

Networked: 204 relevant articles (4 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tamiolakis, D: 4 articles (01/2006 - 01/2001)
2.	Papadopoulos, N: 4 articles (01/2006 - 01/2001)
3.	Valent, Peter: 3 articles (12/2015 - 04/2011)
4.	Horny, Hans-Peter: 3 articles (12/2015 - 04/2011)
5.	Sotlar, Karl: 3 articles (12/2015 - 04/2011)
6.	Venizelos, J: 3 articles (01/2006 - 01/2005)
7.	Kouskoukis, C: 3 articles (01/2006 - 01/2005)
8.	Lambropoulou, M: 3 articles (01/2006 - 01/2005)
9.	Koutsougeras, G: 3 articles (01/2006 - 01/2005)
10.	Latza, U: 3 articles (06/2001 - 04/2000)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1989 - "The expression of Ki-1 antigen by most tumor cells was the distinctive immunologic character of this disorder which helped to clarify the pathological diagnosis. " 10/15/1990 - "In this study, using monoclonal antibody Ki-1, expression of CD30 antigen was immunohistochemically examined in frozen sections of 28 benign and 63 malignant mesenchymal tumors. " 12/01/1988 - "In this study expression of CD30 antigen in 117 nonhematopoietic tumors was investigated using monoclonal antibody Ber-H2. " 02/01/2014 - "First Hodgkin cell line L428 and the CD30 antigen: their role for diagnostic and treatment of CD30-positive neoplasms." 01/01/2013 - "On histopathological examination, thyroid tumor cells were positive for CD15 and CD30 antigen, which is typical for Reed-Sternberg cells. "
2.	Hodgkin Disease (Hodgkin's Disease) 07/01/2002 - "Expression of CD30 antigen is a distinct marker of lymphocyte activation that was originally described in the Reed-Sternberg cells of Hodgkin's disease. " 05/01/1998 - "Biopsy specimens of this lesion revealed intracerebral Hodgkin's lymphoma, a diagnosis supported by immunohistochemical reactions of the tumour cells for the CD30 antigen. " 12/01/1994 - "The CD30 antigen was originally described as a specific surface marker for Hodgkin's lymphoma. " 06/01/1994 - "A monoclonal antibody to the Hodgkin's disease-associated antigen CD30 induces activation and long-term growth of human autoreactive gamma delta T cell clone." 12/01/1993 - "To assess the effect of microwave heating on immunohistochemical staining of CD15 and CD30 antigens in Hodgkin's disease tissue samples. "
3.	Lymphoma (Lymphomas) 12/01/1992 - "A significantly greater proportion of cases of ALC lymphoma compared with HD exhibited positive results for CD45, EMA, CD45RO, and CD3 in CD30-positive atypical large cells, whereas Reed-Sternberg cells in HD most frequently coexpressed CD15 and CD30 antigens. " 01/01/2012 - "Like several human lymphomas the neoplastic MD lymphoma cells overexpress the CD30 antigen (CD30(hi)) and are in minority, while the non-neoplastic cells (CD30(lo)) form the majority of population. " 01/01/2012 - "They bound with high specificity to both recombinant antigen CD30 and to CD30(+) lymphoma cells. " 07/01/2004 - "Frequent expression of CD30 antigen in the primary gastric non-B, non-Hodgkin lymphomas." 11/01/2001 - "Large cell anaplastic lymphoma (ALCL) is characterized mainly by the presence of large, atypical lymphoid cells with anaplastic nuclear morphology and positivity to Ki-1 antigen. "
4.	Synovial Sarcoma (Synovioma) 09/01/1992 - "ICC permitted the correct identification and differential diagnosis of four additional tumors: a positive immunoreaction for thyroglobulin identified a metastatic Hürthle cell carcinoma of the thyroid; a coexpression of two distinct classes of intermediate filaments helped support the FNA diagnoses of a parathyroid adenoma and of a synovial sarcoma; and the double immunoreaction for CD15 and CD30 antigens helped identify Reed-Sternberg cells within an unusually suppurative harvest. "
5.	Parathyroid Neoplasms (Parathyroid Neoplasm) 09/01/1992 - "ICC permitted the correct identification and differential diagnosis of four additional tumors: a positive immunoreaction for thyroglobulin identified a metastatic Hürthle cell carcinoma of the thyroid; a coexpression of two distinct classes of intermediate filaments helped support the FNA diagnoses of a parathyroid adenoma and of a synovial sarcoma; and the double immunoreaction for CD15 and CD30 antigens helped identify Reed-Sternberg cells within an unusually suppurative harvest. "

Related Drugs and Biologics

1.	Bispecific Antibodies
2.	Thyroglobulin
3.	Antigens
4.	CD45 Antigens (CD45 Antigen)
5.	Interleukin-2 Receptors (IL 2 Receptor)
6.	Mucin-1 (CA 15-3 Antigen)
7.	HLA-DR Antigens (HLA-DR)
8.	Paraffin
9.	cAC10-vcMMAE
10.	S100 Proteins (S 100 Protein)

Related Therapies and Procedures

1.	Immunotherapy
2.	Transplantation (Transplant Recipients)
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Orchiectomy (Orchidectomy)
5.	Drug Therapy (Chemotherapy)