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Leukocyte Transfusion

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The transfer of leukocytes from a donor to a recipient or reinfusion to the donor.

Also Known As:

Transfusion, White Blood Cell; Transfusions, White Blood Cell; White Blood Cell Transfusions; Leukocyte Transfusions; Transfusion, Leukocyte; Transfusions, Leukocyte; White Blood Cell Transfusion

Networked: 92 relevant articles (12 outcomes, 4 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 15318
- Biological Therapy: 2317
  - Blood Transfusion: 12511
    - Blood Component Transfusion: 52
      - Leukocyte Transfusion: 92
        Lymphocyte Transfusion: 35

Experts

1.	Nakao, S: 2 articles (12/2000 - 04/2000)
2.	Kyle Wathen, J: 1 article (04/2013)
3.	Reddy, V: 1 article (04/2013)
4.	Lichtiger, B: 1 article (04/2013)
5.	Freireich, E J: 1 article (04/2013)
6.	Martinez, F: 1 article (04/2013)
7.	Mattiuzzi, G: 1 article (04/2013)
8.	Schmidtke, Joerg: 1 article (07/2011)
9.	Provasi, Elena: 1 article (07/2011)
10.	Silvani, Anna: 1 article (07/2011)

Related Diseases

1.	Leukemia 11/01/1997 - "The anti-leukemia effect of donor leukocyte transfusion was strongest against CML in cytogenetic and chronic phase and induce a durable complete remission." 11/01/1997 - "We studies the efficacy of donor leukocyte transfusion (DLT) on acute and chronic leukemia in relapse after bone marrow transplantation in Japan. " 04/01/2013 - "A prospective, randomized, double-blind study, comparing unirradiated to irradiated white blood cell transfusions in acute leukemia patients." 07/01/2011 - "Genetically modified donor leukocyte transfusion and graft-versus-leukemia effect after allogeneic stem cell transplantation." 01/01/1999 - "Administration of rIL-2 and adoptive transfer of graft-derived LAK cells are considered to be possible choices for the treatment of acute leukemia relapsing after uBMT when donor leukocyte transfusion is not available."
2.	Graft vs Host Disease (Graft-Versus-Host Disease) 07/01/1998 - "Adoptive immunotherapy with donor leukocyte transfusion, including appropriate numbers of CD3-positive T cells, was effective for the EB-LPD, achieving almost complete recovery 1 year later without any findings of graft-versus-host disease." 10/01/2003 - "Transfusion-associated graft vs. host disease after donor-specific leukocyte transfusion before kidney transplantation." 07/01/1995 - "Acute graft-versus-host disease (GVHD) did not develop even after an interval of 50 days from the last donor leukocyte transfusion (DLT). " 06/01/1992 - "Amelioration of graft-versus-host disease following bowel transplantation with recipient specific leukocyte transfusion." 06/01/1984 - "Thus, the data indicate that irradiation in doses used to prevent graft-versus-host disease in leukocyte transfusion recipients has a deleterious effect on in vitro human monocyte survival and function."
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 08/01/1996 - "Transient complete remission of acute lymphoblastic leukemia in relapse after allogeneic bone marrow transplantation induced by donor leukocyte transfusions." 12/01/2000 - "CD8-depleted donor leukocyte transfusions for cytomegalovirus antigenemia in patient with acute lymphoblastic leukemia treated with allogeneic CD34(+) cell transplantation." 01/10/2000 - "[Donor leukocyte transfusion in early relapsed acute lymphoblastic leukemia after allogenic bone marrow transplantation]." 03/01/1996 - "Grade IV graft-versus-host disease and a 1-year remission following donor leukocyte transfusion for treatment of relapsed acute lymphoblastic leukemia." 10/01/2001 - "Successful eradication of residual bcr-abl-positive clones by donor leukocyte transfusion in a patient with philadelphia chromosome-positive acute lymphoblastic leukemia after peripheral blood stem cell transplantation."
4.	Sepsis (Septicemia) 11/01/1984 - "Improved survival of newborns receiving leukocyte transfusions for sepsis." 01/01/1989 - "Some recent clinical studies have suggested the benefit of using adult neutrophil transfusions as adjuvant treatment during neonatal bacterial sepsis, yet other studies have found the use of polymorphonuclear neutrophil leukocyte transfusions to be inconclusive. " 01/01/1982 - "In this paper we review the evidence for these neonatal neutrophil deficiencies and examine the animal and clinical studies which have tested leukocyte transfusion as a possible adjunctive therapeutic modality for sepsis neonatorum." 11/01/1984 - "To determine the role of polymorphonuclear (PMN) leukocyte transfusions in neonates with sepsis, 23 consecutive newborns were prospectively randomly selected during an 18-month period in a treatment plan to receive polymorphonuclear leukocyte transfusions with supportive care or supportive care alone. " 01/01/1982 - "Review: deficiencies in the neutrophil system of newborn infants, and the use of leukocyte transfusions in the treatment of neonatal sepsis."
5.	Agranulocytosis (Granulocytopenia) 01/01/1982 - "This study suggests that leukocyte transfusions from unstimulated normal donors are effective in the management of patients with potentially reversible granulocytopenia." 08/20/1977 - "Leukocyte transfusions thus have an important adjuvant role in the management of patients with severe granulocytopenia." 01/01/1971 - "Histocompatible leukocyte transfusion during granulocytopenia." 04/23/1966 - "[The symptomatic treatment of agranulocytosis by leukocyte transfusion]." 08/20/1977 - "Seven patients with acute myelogenous leukemia received HLA-matched leukocytes during the period of maximal granulocytopenia associated with initial remission induction therapy; 20 concurrently treated patients who did not receive leukocyte transfusions were the control group. "

Related Drugs and Biologics

1.	Granulocyte Colony-Stimulating Factor (G-CSF)
2.	Immunosuppressive Agents (Immunosuppressants)
3.	Interleukin-12 (IL 12)
4.	Interferon-alpha (Interferon Alfa)
5.	Lithium Carbonate (Eskalith)
6.	Cytokines
7.	T-Cell Antigen Receptors (T-Cell Receptor)
8.	Pancuronium (Pavulon)
9.	Nitroblue Tetrazolium
10.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
2.	Transplants (Transplant)
3.	Drug Therapy (Chemotherapy)
4.	Stem Cell Transplantation
5.	Transplantation (Transplant Recipients)