Soft Tissue Injuries (Soft Tissue Injury)

Injuries of tissue other than bone. The concept is usually general and does not customarily refer to internal organs or viscera. It is meaningful with reference to regions or organs where soft tissue (muscle, fat, skin) should be differentiated from bones or bone tissue, as "soft tissue injuries of the hand".

Also Known As:

Networked: 581 relevant articles (39 outcomes, 66 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Wounds and Injuries (Trauma)
3.	Infection
4.	Sprains and Strains (Sprain)
5.	Osteoarthritis

Experts

1.	Mittlmeier, Thomas: 4 articles (03/2013 - 01/2005)
2.	Webb, Lawrence X: 4 articles (01/2011 - 04/2002)
3.	Bosse, Michael J: 4 articles (06/2010 - 04/2002)
4.	MacKenzie, Ellen J: 4 articles (06/2010 - 04/2002)
5.	Kirk, Kevin L: 4 articles (03/2010 - 05/2004)
6.	Alpar, E K: 4 articles (01/2001 - 04/2000)
7.	Onuoha, G N: 4 articles (01/2001 - 04/2000)
8.	Vollmar, Brigitte: 3 articles (03/2013 - 01/2005)
9.	Bocharova, Vera: 3 articles (01/2011 - 09/2010)
10.	Wang, Joseph: 3 articles (01/2011 - 09/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Soft Tissue Injuries:

1.	Ibuprofen (Motrin)FDA LinkGeneric 03/01/2002 - "The efficacy of a novel, proprietary topical formulation of ibuprofen 5% gel (Ibugel) was evaluated in a placebo-controlled study in patients with soft tissue injuries. " 03/01/2002 - "Efficacy of a proprietary ibuprofen gel in soft tissue injuries: a randomised, double-blind, placebo-controlled study." 12/01/2002 - "Comparative efficacy of a proprietary topical ibuprofen gel and oral ibuprofen in acute soft tissue injuries: a randomized, double-blind study." 09/01/1994 - "One hundred patients who presented to the accident and emergency (A&E) department with an acute ankle sprain were entered into a study to determine the efficacy of topical ibuprofen cream by using a double-blind placebo controlled design in a single type of soft-tissue injury. " 12/01/2002 - "The efficacy of a novel, proprietary topical formulation of ibuprofen 5% gel (Ibugel) and ibuprofen 400 mg tablets (1200 mg daily) was compared in a double-blind, double-dummy, parallel group study in patients with acute soft tissue injuries. "
2.	nabumetone (nabumeton)FDA LinkGeneric 04/01/1993 - "To review the pharmacology, pharmacokinetic disposition, dosage recommendations, adverse effects, drug interactions, and efficacy of nabumetone in patients with selected rheumatic disorders and soft-tissue injuries. " 10/30/1987 - "Nabumetone in the treatment of skin and soft tissue injury." 01/01/2004 - "The clinical efficacy of nabumetone has also been evaluated in patients with ankylosing spondylitis, soft tissue injuries and juvenile RA. " 10/30/1987 - "Nabumetone, a new nonsteroidal anti-inflammatory agent, has been evaluated for the treatment of skin and soft tissue injury, including sports injury, in clinical trials involving nearly 1,000 patients. " 04/01/1993 - "Nabumetone also has been studied in ankylosing spondylitis and soft-tissue injuries. "
3.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/01/1985 - "The study suggests that fenoprofen calcium is effective for use in treating soft-tissue injuries since it is better tolerated than aspirin when given in equally effective doses." 01/01/1985 - "Results of the study showed that fenoprofen calcium and aspirin were equally effective in treating acute inflammatory soft-tissue injuries; however, adverse experiences occurred in fewer patients and at a lower frequency with fenoprofen calcium therapy. " 03/24/1986 - "In the first study, soft tissue injuries to the lower limb in 51 professional soccer players were treated for six days with 150 mg of flurbiprofen per day or 3.6 g of aspirin per day. " 03/01/1980 - "A double-blind trial of ibuprofen and aspirin in the treatment of soft-tissue injuries sustained in professional football." 02/01/1977 - "A double-blind trial of flurbiprofen (150 mg daily) and aspirin (3.6 g daily) for six days was carried out in 52 soft-tissue injuries in 28 professional footballers. "
4.	diclofenac hydroxyethylpyrrolidine (DIEP)FDA Link 09/01/2013 - "To investigate the efficacy and safety of a topical plaster containing diclofenac epolamine (DHEP) 1.3% in the treatment of patients with acute minor soft tissue injuries in China. " 09/01/2013 - "Diclofenac epolamine medicated plaster in the treatment of minor soft tissue injuries: a multicenter randomized controlled trial." 08/01/2011 - "In conclusion, the diclofenac epolamine topical patch provides effective, rapid pain relief for the treatment of acute pain from minor soft tissue injury and appears generally safe and well tolerated." 08/01/2011 - "This randomized, double-blind, placebo-controlled study evaluated the safety and efficacy of the diclofenac epolamine topical patch for the treatment of acute pain due to minor soft tissue injury. " 10/01/2010 - "Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury."
5.	Naproxen (Naprosyn)FDA LinkGeneric 01/01/1990 - "A double-blind study was carried out in 120 patients who had received soft tissue injuries within the preceding 48 hours to compare the effectiveness of naproxen gel (10%) with placebo gel (base alone). " 01/01/1990 - "A double-blind comparison of naproxen gel and placebo in the treatment of soft tissue injuries." 01/01/1990 - "One hundred patients were enrolled in a single-blind, randomized, parallel group study to compare naproxen gel (10%) with flufenamic acid gel (3%) for the treatment of soft tissue injuries. " 09/01/2007 - "Naproxen versus acetaminophen for therapy of soft tissue injuries to the ankle in children." 01/01/1994 - "Single blind study to evaluate the efficacy and safety of naproxen gel compared with diclophenac emulgel in the treatment of soft tissue injuries."
6.	Diclofenac (SR 38)FDA LinkGeneric 11/01/2008 - "The principle outcome of these studies is that topical diclofenac is a safe and practical alternative as a method of treatment in OA of the knee or as an alternative treatment for sports and soft tissue injury." 12/17/2003 - "We discuss the clinical relevance of patches containing an NSAID by demonstrating the efficacy and safety of a newly developed diclofenac patch in the topical treatment of blunt impact soft tissue injuries in a randomised, placebo controlled, double blind, multicentre study. " 01/01/1995 - "In a randomized, double-blind, parallel-group, multicenter study, the efficacy and tolerability of diclofenac dispersible were compared with placebo in the treatment of acute soft-tissue injuries. " 01/01/1995 - "Double-blind, multicenter evaluation of the efficacy and tolerability of diclofenac dispersible in the treatment of acute soft-tissue injuries." 11/01/2008 - "Topical diclofenac significantly reduced pain and morning stiffness and improved physical function and patient global assessment without major adverse effects reported in patients with OA of the knee; and provided significant pain relief in patients with sports and soft tissue injuries involving the ankle, knee or shoulder. "
7.	Ketoprofen (Orudis)FDA LinkGeneric 11/01/1993 - "A parallel, double-blind, placebo controlled and randomized study in a single center was done with ketoprofen 2.5% gel to treat acute soft tissue injuries. " 05/01/1996 - "In conclusion, ketoprofen gel may offer benefits over established therapies for the treatment of acute soft-tissue injury." 11/01/1993 - "Our results suggested that ketoprofen 2.5% gel was safe and superior to placebo in the treatment of soft tissue injuries." 11/01/1993 - "Ketoprofen 2.5% gel versus placebo gel in the treatment of acute soft tissue injuries." 01/01/1979 - "Ketoprofen in the treatment of soft tissue injury."
8.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 08/01/1991 - "Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to be effective in the treatment of acute soft tissue injuries. " 10/01/1997 - "Clinical trials of NSAIDs in the treatment of acute soft tissue injuries have shown conflicting results and have been highly criticized. " 05/01/2014 - "Current approaches to managing soft tissue injuries often rely upon the use of non-steroidal anti-inflammatory drugs (NSAIDs). " 05/01/2011 - "This article examines the effects and potential side effects of NSAIDs, and considers alternative prescribing options for treating soft-tissue injuries." 06/01/2010 - "Topical NSAIDs provide a therapeutic option for treatment of acute, localized, soft tissue injuries or painful conditions in areas of the body that can be readily treated using the topical route of administration. "
9.	Indomethacin (Indometacin)FDA LinkGeneric 11/01/2014 - "During the study period, the senior author used indomethacin for HO prophylaxis in patients who had ipsilateral femur fracture treated with antegrade reamed medullary nailing or severe local soft tissue injury; 49 (10%) of the patients he treated with the Kocher-Langenbeck approach received prophylaxis, and they were excluded from this study, leaving a total of 459 patients who met inclusion criteria. " 08/01/1973 - "Indomethacin for soft-tissue injuries. " 01/01/1979 - "Twenty-four professional footballers suffering from recent soft-tissue injuries were included in a double-blind pilot trial comparing the efficacy and tolerability of indoprofen 800 mg/day and indomethacin 80 mg/day. " 01/01/1984 - "One hundred and five patients suffering from sport-associated soft tissue injuries were included in a randomized controlled trial comparing the efficacy and side-effects of piroxicam and indomethacin. " 01/01/1979 - "A comparison of indoprofen and indomethacin in the supportive treatment of soft-tissue injuries in football players: a pilot study."
10.	biphenylylacetic acid (felbinac)IBA 08/01/1989 - "Two hundred and thirty-one patients with acute soft tissue injuries were treated in a double-blind placebo-controlled study of felbinac (biphenylacetic acid) gel applied three times daily to the injured site. " 08/01/1989 - "Felbinac is an effective management for acute soft tissue injuries and because of its topical application may be safer than oral non-steroidal anti-inflammatory drugs for the treatment of these conditions." 08/01/1990 - "Comparison of the efficacy and tolerability of diclofenac gel (Voltarol Emulgel) and felbinac gel (Traxam) in the treatment of soft tissue injuries." 01/01/1994 - "However, four separate multicentre, double-blind, double-dummy clinical trials have shown that the efficacy of the topical NSAID, felbinac, is equivalent to that of the oral NSAID, ibuprofen, in the treatment of soft tissue injuries, and to that of oral ibuprofen or fenbufen in mild to moderate osteoarthritis. "

Therapies and Procedures

1.	Amputation 03/01/2015 - "This study confirms that osteomuscular latissimus dorsi scapula flap reconstruction is a suitable alternative for compound and comminuted tibia fractures especially in the case of extensive soft tissue injury with bony loss or significant comminution and with high probability of amputation." 06/01/2014 - "Maximising residual stump length carries the risks of definitive level amputation within the original ZOI but this study demonstrates that the proximal extent of the soft tissue injury may frequently make this unavoidable. " 03/01/2015 - "There was one late death and one major amputation of a stented limb in a patient who had sustained severe soft-tissue injuries during the follow-up period. " 12/01/2014 - "In amputation group, there were 26 males and 12 females with an average age of (44.9±16.3) years old; and 21 cases were type Gustilo (III B, 17 cases were Gustilo III C; amputation were performed in accordance with soft tissue injury degree of shank, fracture types and surgical exploration. " 01/01/2014 - "There is a higher risk for amputations with age above 70 (in contrast: male sex and tissue reconstruction are rather indicators for more severe soft tissue injuries). "
2.	Debridement 07/01/2015 - "Soft tissue injuries were treated by aggressive debridement. " 06/01/2014 - "Detailed anatomical data on pre-debridement osseous and soft tissue injury levels were only consistently available for fatalities through PM-CT findings. " 02/01/2013 - "Soft tissue injuries were treated by aggressive debridement. " 02/01/2012 - "Open distal humerus fractures present significant soft-tissue injury and bone devitalization that require prompt irrigation and debridement, temporization, and soft-tissue coverage. " 04/01/2011 - "Serial debridement and minimal repair of soft tissue injuries as well as splinting of the mandible was done under local anaeasthesia. "
3.	Resuscitation 10/01/2013 - "However, the prognosis can be improved by successful revival and rehabilitation of these patients, which is possible by early resuscitation, recognition of all bony and soft tissue injuries, early debridement and coverage." 11/01/2011 - "C57BL/6J-KitW-sh/BsmJ (mast cell deficient) and wild type mice were subjected to 1.5 hours of hemorrhagic shock plus bilateral femur fracture and soft tissue injury (HS/T), followed by resuscitation at 4.5 hours. " 04/01/1995 - "Anesthetized pigs received a soft tissue injury + hemorrhage, and fluid resuscitation after 1 h. " 03/01/2007 - "Male C3H/HeN mice underwent midline laparotomy (i.e., soft tissue injury), hemorrhagic shock (MAP approximately 35 mm Hg for 90 min), and resuscitation. " 07/01/1996 - "After 60 minutes, all were subjected to soft tissue injury and 30 to 35% hemorrhage, 60-minute shock, and then resuscitation, with shed blood plus supplemental LR. "
4.	Skin Transplantation (Skin Grafting) 01/01/2015 - "Soft tissue injuries with full-thickness skin involvement not amenable to local flaps may be treated with dermal matrices and subsequent skin grafting. " 09/01/2009 - "Many textbooks and original articles have been published on aspects of managing soft tissue injuries and skin grafting. " 02/21/2006 - "Problems after severe soft tissue injuries, skin grafting, and flap procedures are uncontrolled hypertrophic scarring, unstable scars, functional deficits, and aesthetic disfigurements. " 08/01/1982 - "We believe that prompt and complete angiography whenever the general condition of the patient allows it, early fasciotomy when indicated before vascular repair, thrombectomy of the injured artery and vein and local instillation of heparinized saline solution, vascular repair before orthopedic stabilization of fractures in selected cases, external fixation of the fracture when there is significant soft tissue injury, and early skin grafting resulted in an improved level of care with a low morbidity and no mortality in our series." 10/01/2012 - "Numerous other studies have proved that TNPT is beneficial for a myriad of other wounds including: sternotomy wounds, extensive de-gloving injuries, various soft tissue injuries prior to surgical closure, skin grafting, pressure sores, leg ulcers, sacral pressure ulcers, acute traumatic soft tissue defects, and soft tissue defects following rigid stabilisation of lower extremity fractures. "
5.	Sternotomy 10/01/2012 - "Numerous other studies have proved that TNPT is beneficial for a myriad of other wounds including: sternotomy wounds, extensive de-gloving injuries, various soft tissue injuries prior to surgical closure, skin grafting, pressure sores, leg ulcers, sacral pressure ulcers, acute traumatic soft tissue defects, and soft tissue defects following rigid stabilisation of lower extremity fractures. "