Soft Tissue Injuries (Soft Tissue Injury)

Injuries of tissue other than bone. The concept is usually general and does not customarily refer to internal organs or viscera. It is meaningful with reference to regions or organs where soft tissue (muscle, fat, skin) should be differentiated from bones or bone tissue, as "soft tissue injuries of the hand".

Also Known As:

Networked: 1075 relevant articles (68 outcomes, 106 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Wounds and Injuries (Trauma)
3.	Infections
4.	Osteoarthritis
5.	Open Fractures (Compound Fracture)

Experts

1.	Pape, Hans-Christoph: 5 articles (02/2022 - 06/2010)
2.	Mittlmeier, Thomas: 4 articles (03/2013 - 01/2005)
3.	Webb, Lawrence X: 4 articles (01/2011 - 04/2002)
4.	Bosse, Michael J: 4 articles (06/2010 - 04/2002)
5.	MacKenzie, Ellen J: 4 articles (06/2010 - 04/2002)
6.	Kirk, Kevin L: 4 articles (03/2010 - 05/2004)
7.	Alpar, E K: 4 articles (01/2001 - 04/2000)
8.	Onuoha, G N: 4 articles (01/2001 - 04/2000)
9.	Khan, Moin: 3 articles (02/2022 - 07/2015)
10.	Halvachizadeh, Sascha: 3 articles (02/2022 - 01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Soft Tissue Injuries:

1.	Ibuprofen (Motrin)FDA LinkGeneric 03/01/2002 - "The efficacy of a novel, proprietary topical formulation of ibuprofen 5% gel (Ibugel) was evaluated in a placebo-controlled study in patients with soft tissue injuries. " 03/01/2002 - "Efficacy of a proprietary ibuprofen gel in soft tissue injuries: a randomised, double-blind, placebo-controlled study." 12/01/2002 - "Comparative efficacy of a proprietary topical ibuprofen gel and oral ibuprofen in acute soft tissue injuries: a randomized, double-blind study." 01/01/2018 - "It is proposed that the known COX2-mediated anti-inflammatory effect of ibuprofen has detrimental effects on the turnover of a pro-inflammatory HA matrix produced in response to soft-tissue injury, thus preventing the switch to cellular responses associated with functional matrix remodeling and eventual healing." 11/01/2017 - "Efficacy and safety assessment of acute sports-related traumatic soft tissue injuries using a new ibuprofen medicated plaster: results from a randomized controlled clinical trial."
2.	diclofenac hydroxyethylpyrrolidine (DIEP)FDA Link 01/01/2022 - "Safety and Efficacy of the FLECTOR (Diclofenac Epolamine) Topical System in Children with Minor Soft Tissue Injuries: A Phase IV Non-randomized Clinical Trial." 09/01/2013 - "To investigate the efficacy and safety of a topical plaster containing diclofenac epolamine (DHEP) 1.3% in the treatment of patients with acute minor soft tissue injuries in China. " 09/01/2013 - "Diclofenac epolamine medicated plaster in the treatment of minor soft tissue injuries: a multicenter randomized controlled trial." 01/01/2022 - "The FLECTOR topical system safely and effectively provided pain relief for minor soft tissue injuries in the pediatric population, with minimal systemic nonsteroidal anti-inflammatory drug exposure and low potential risk of local or systemic adverse events. " 08/01/2011 - "This randomized, double-blind, placebo-controlled study evaluated the safety and efficacy of the diclofenac epolamine topical patch for the treatment of acute pain due to minor soft tissue injury. "
3.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 08/01/1991 - "Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to be effective in the treatment of acute soft tissue injuries. " 10/01/1997 - "Clinical trials of NSAIDs in the treatment of acute soft tissue injuries have shown conflicting results and have been highly criticized. " 08/01/1990 - "In an observer-blind, randomised study, the efficacy and tolerability of two topical NSAID preparations were assessed in 384 patients with acute soft tissue injuries. " 05/01/2014 - "Current approaches to managing soft tissue injuries often rely upon the use of non-steroidal anti-inflammatory drugs (NSAIDs). " 11/06/2012 - "Evidence on NSAID use in soft tissue injuries."
4.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/01/1985 - "The study suggests that fenoprofen calcium is effective for use in treating soft-tissue injuries since it is better tolerated than aspirin when given in equally effective doses." 03/24/1986 - "In the first study, soft tissue injuries to the lower limb in 51 professional soccer players were treated for six days with 150 mg of flurbiprofen per day or 3.6 g of aspirin per day. " 03/01/1980 - "A double-blind trial of ibuprofen and aspirin in the treatment of soft-tissue injuries sustained in professional football." 02/01/1977 - "A double-blind trial of flurbiprofen (150 mg daily) and aspirin (3.6 g daily) for six days was carried out in 52 soft-tissue injuries in 28 professional footballers. " 01/01/1985 - "Fenoprofen calcium versus aspirin in the treatment of acute inflammatory soft-tissue injuries."
5.	Naproxen (Naprosyn)FDA LinkGeneric 01/01/1990 - "A double-blind study was carried out in 120 patients who had received soft tissue injuries within the preceding 48 hours to compare the effectiveness of naproxen gel (10%) with placebo gel (base alone). " 01/01/1990 - "A double-blind comparison of naproxen gel and placebo in the treatment of soft tissue injuries." 01/01/1990 - "One hundred patients were enrolled in a single-blind, randomized, parallel group study to compare naproxen gel (10%) with flufenamic acid gel (3%) for the treatment of soft tissue injuries. " 01/01/1994 - "Single blind study to evaluate the efficacy and safety of naproxen gel compared with diclophenac emulgel in the treatment of soft tissue injuries." 01/01/1990 - "A comparative study of naproxen gel and flufenamic acid gel in the treatment of soft tissue injuries."
6.	TabletsIBA 01/01/2023 - "In patients with bone and soft tissue injuries of the wrist, hand, and/or fingers, prescribing feedback-guided exercises performed on a tablet touchscreen was more effective for improving patients' functional ability and reduced the number of patients referred to rehabilitation consultation and number of clinical appointments." 10/01/2020 - "In people with bone and soft-tissue injuries of the wrist, hand and/or fingers, prescribing a feedback-guided home exercise program using a tablet-based application instead of a conventional program on paper hastened return to work and improved the short-term recovery of functional ability and pinch strength, while reducing the number of required healthcare appointments. " 01/01/2023 - "To assess whether feedback-guided exercises performed on a tablet touchscreen improve clinical recovery and reduce health care usage more than the conventional home exercise program prescribed on paper in patients with bone and soft tissue injuries of the wrist, hand, and/or fingers treated by public health services. " 10/01/2020 - "In people with bone and soft tissue injuries of the wrist, hand and/or fingers, do feedback-guided exercises performed on a tablet touchscreen hasten return to work, reduce healthcare usage and improve clinical recovery more than a home exercise program prescribed on paper? " 01/01/2023 - "Effectiveness of a Telerehabilitation Evidence-Based Tablet App for Rehabilitation in Traumatic Bone and Soft Tissue Injuries of the Hand, Wrist, and Fingers."
7.	NabumetoneFDA LinkGeneric 04/01/1993 - "To review the pharmacology, pharmacokinetic disposition, dosage recommendations, adverse effects, drug interactions, and efficacy of nabumetone in patients with selected rheumatic disorders and soft-tissue injuries. " 10/30/1987 - "Nabumetone in the treatment of skin and soft tissue injury." 01/01/2004 - "The clinical efficacy of nabumetone has also been evaluated in patients with ankylosing spondylitis, soft tissue injuries and juvenile RA. " 04/01/1993 - "Nabumetone also has been studied in ankylosing spondylitis and soft-tissue injuries. " 10/30/1987 - "Nabumetone, a new nonsteroidal anti-inflammatory agent, has been evaluated for the treatment of skin and soft tissue injury, including sports injury, in clinical trials involving nearly 1,000 patients. "
8.	Diclofenac (SR 38)FDA LinkGeneric 11/01/2008 - "The principle outcome of these studies is that topical diclofenac is a safe and practical alternative as a method of treatment in OA of the knee or as an alternative treatment for sports and soft tissue injury." 01/01/1995 - "In a randomized, double-blind, parallel-group, multicenter study, the efficacy and tolerability of diclofenac dispersible were compared with placebo in the treatment of acute soft-tissue injuries. " 01/01/1995 - "Double-blind, multicenter evaluation of the efficacy and tolerability of diclofenac dispersible in the treatment of acute soft-tissue injuries." 11/01/2008 - "Topical diclofenac significantly reduced pain and morning stiffness and improved physical function and patient global assessment without major adverse effects reported in patients with OA of the knee; and provided significant pain relief in patients with sports and soft tissue injuries involving the ankle, knee or shoulder. " 04/01/2008 - "Double-blind, randomized, placebo- or active-controlled trials (RCT) evaluating topical diclofenac in soft-tissue injuries, soft-tissue rheumatic disorders and osteoarthritis were identified through detailed literature searches. "
9.	SolutionsIBA 10/10/2016 - "It is concluded that the proposed procedure is a viable solution for re-gaining highly functional hand use following critical soft tissue injuries when existing surgical measures fail. " 01/01/2018 - "Percutaneous direct current stimulation - a new electroceutical solution for severe neurological pain and soft tissue injuries." 08/01/1994 - "Fluid loading with balanced salt solution (BSS) was carried out in 200 patients with extensive soft tissue injuries from severe beatings. " 08/01/1994 - "Balanced salt solution volume diuresis supplemented with furosemide as necessary appears to be safe and effective in preventing AIRF in soft tissue injuries sustained in beatings." 05/01/1993 - "Soft tissue injuries were treated by routine procedures of war surgery, associated with ample use of Lavasept, an antiseptic solution (Fresenius, Stans, Switzerland), which has proved to be highly efficacious in preventing and decontaminating infection without disturbance of the wound healing process. "
10.	Analgesics (Analgesic Drugs)IBA 08/01/2019 - "Analgesic Effect of Sinew Acupuncture for Patients with Soft-Tissue Injuries: A Pilot Trial." 07/18/2023 - "The patient went to another hospital before presenting to us where he was diagnosed to have a soft tissue injury and was discharged home on simple analgesics. " 01/01/2021 - "Cochrane in CORR®: Oral Nonsteroidal Anti-inflammatory Drugs versus Other Oral Analgesic Agents for Acute Soft Tissue Injury." 12/15/2020 - "Jones P, Lamdin R, Dalziel SR. Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. " 12/01/2020 - "Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury."

Therapies and Procedures

1.	Therapeutics 09/01/2003 - "Cold gel therapy provided an effective and safe treatment for sports-related soft tissue injuries." 11/01/2014 - "Microcurrent therapy (MCT) is a novel treatment method used in soft tissue injury and tissue regeneration therapy. " 07/01/2019 - "All English-language randomized trials comparing platelet-rich therapy with a control in patients 18 years or older with musculoskeletal bone, cartilage, or soft tissue injuries treated either conservatively or surgically were included. " 01/01/2023 - "Low-intensity Continuous Ultrasound (LICUS) therapy heals soft tissue injuries. " 07/01/2021 - "This is a retrospective study of patients with soft tissue injury who underwent PRP therapy between 2015 and 2018 at an orthopaedic and traumatology hospital. "
2.	Surgical Amputation (Amputations) 03/01/2015 - "This study confirms that osteomuscular latissimus dorsi scapula flap reconstruction is a suitable alternative for compound and comminuted tibia fractures especially in the case of extensive soft tissue injury with bony loss or significant comminution and with high probability of amputation." 06/01/2014 - "Maximising residual stump length carries the risks of definitive level amputation within the original ZOI but this study demonstrates that the proximal extent of the soft tissue injury may frequently make this unavoidable. " 07/01/2017 - "All extremity injury codes were included, capturing patients with soft tissue injuries but no fracture or amputation. " 01/01/2017 - "Therapeutic advances in the treatment of vascular, orthopedic, neurologic, and soft tissue injuries have reduced the diagnostic accuracy of the MESS in predicting the need for amputation. " 10/10/2016 - "Elective amputation and bionic substitution restore functional hand use after critical soft tissue injuries."
3.	Debridement 01/01/2023 - "Defect size after debridement may be more prognostic for secondary operations rather than the limb segment involved or the degree of soft-tissue injury. " 07/01/2022 - "The cases were divided into three groups by degree of associated soft tissue injuries: (A) adequate soft tissue coverage over the injured major vessels after radical debridement, (B) inadequate soft tissue coverage over the injured major vessels after radical debridement, and (C) radical debridement was not feasible due to unclear extent of injured soft tissue. " 11/01/2018 - "The most common surgical treatment was facial soft-tissue injury debridement and closure. " 05/01/2018 - "These include the rationale for initial debridement, antimicrobial cover, addressing the soft-tissue injury and definitive skeletal management.The" 01/01/2018 - "In both groups, OAT procedures included arthroscopic inspection and debridement of concomitant soft tissue injuries. "
4.	Skin Transplantation (Skin Grafting) 09/19/2017 - "Conclusion: VSD can shorten the preoperative waiting time and total hospitalization time, improve the wound healing rate directly, reduce the skin grafting and flap transfer replacement rate, reduce the secondary injury, increased fracture risk reduction and internal fixation, reduce joint fusion rate in the treatment of foot closed complex fracture and dislocation with severe soft tissue injury. " 01/01/2015 - "Soft tissue injuries with full-thickness skin involvement not amenable to local flaps may be treated with dermal matrices and subsequent skin grafting. " 09/01/2009 - "Many textbooks and original articles have been published on aspects of managing soft tissue injuries and skin grafting. " 01/01/2017 - "However, for open tibia fractures with extensive and severe soft tissue injury, especially Gustilo type III patients who achieved wound heal after flap transfer or skin grafting, the choice of secondary conversion to internal fixation should carried out cautiously. " 02/21/2006 - "Problems after severe soft tissue injuries, skin grafting, and flap procedures are uncontrolled hypertrophic scarring, unstable scars, functional deficits, and aesthetic disfigurements. "
5.	Length of Stay 03/01/2004 - "The study was designed to establish the incidence and pattern of bone and soft tissue injuries in these patients and to determine whether MRI could provide predictive information regarding length of hospital stay. " 04/01/2020 - "The combination of stereotactic body radiotherapy, contemporary surgical adjuncts, and less-invasive techniques serves to minimize blood loss, soft tissue injury, and length of hospital stay without compromising surgical efficacy, potentially enabling patients to begin adjuvant treatment sooner." 08/01/2018 - "We retrospectively recorded pre-morbid status, fracture and soft tissue injury pattern, surgical details, post-operative mobility, length of hospital stay, complication and re-operation rate and survival. " 07/01/1984 - "The major cause of a prolonged hospital stay was the presence of a major soft-tissue injury, while the presence or absence of a neural injury was the most important determinate of whether the extremity would be functional. " 03/01/2022 - "It is a minimally invasive procedure which offers multiple advantages over open surgical biopsy including maintenance of bone structure, minimal soft tissue injury, reduced need of general anesthesia, reduced hospital stay and a low rate of post-procedure complications. "