Radon Daughters

Short-lived radioactive decay products of radon that include 216-Po, 214-Pb, 214-Bi, and 214-Po. They have an effective half-life of about 30 minutes and are solids that can deposit on the bronchial airways during inhalation and exhalation. This results in exposure of the respiratory airways to alpha radiation and can lead to diseases of the respiratory system, including lung cancer. (From Casarett and Doull's Toxicology, 4th ed, p740)

Also Known As:

Networked: 209 relevant articles (3 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hofmann, W: 8 articles (11/2015 - 02/2000)
2.	Demers, Paul A: 5 articles (01/2022 - 12/2016)
3.	Kreuzer, Michaela: 4 articles (01/2022 - 05/2010)
4.	Laurier, Dominique: 4 articles (01/2022 - 10/2010)
5.	Richardson, David B: 4 articles (01/2022 - 01/2020)
6.	Zablotska, Lydia B: 4 articles (01/2022 - 01/2012)
7.	Hofmann, Werner: 4 articles (01/2020 - 09/2002)
8.	Little, M P: 4 articles (09/2004 - 12/2001)
9.	Kelly-Reif, Kaitlin: 3 articles (01/2022 - 01/2020)
10.	Lane, Rachel S D: 3 articles (01/2022 - 08/2007)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 01/01/2020 - "The proposed method yields an estimate of the expected gain in life expectancy (approximately 6 months per worker) and reduction of 261 lung cancer deaths under a policy that eliminated occupational radon progeny exposure. " 09/01/2010 - "The objective of the present study was to assess the lung cancer risk induced by exposures to radon progeny of people living in some areas of Transylvania, Romania. " 01/01/1998 - "Given the scientific consensus that exposure to radon decay products causes lung cancer, most recent studies have focused on the nature of the exposure-response relationship. " 06/07/1995 - "Studies of miners show that exposure to radon decay products causes lung cancer. " 07/01/1994 - "Both miner-based epidemiological data and animal studies suggest that lung cancer induction from radon-progeny alpha-particle exposure depends on the exposure rate, and increases as the exposure rate decreases. "
2.	Neoplasms (Cancer) 07/10/2021 - "It is held that the skin dose from radon progeny is not negligibly small and that introducing cancer is a possible consequence under normal circumstances as there are a number of uncertainties in terms of related parameters such as activity concentrations in air and water, target cells in skin, skin covering materials, and deposition velocities. " 11/01/2014 - "Mortality from cancers of the extra-thoracic airways in relation to radon progeny in the Wismut cohort, 1946-2008." 05/01/2010 - "A specific focus on a group of cancers of the extrathoracic airways is also made here, due to the assumed high organ doses from absorbed radon progeny. " 01/01/1991 - "The considerable radiosensitivity of the human lung together with the highly localized alpha-doses in the bronchial and pulmonary regions from naturally occurring and man-enhanced radon decay products make the respiratory tract the most critical organ for cancer from exposure to ionizing radiation in our environment. " 01/01/1990 - "Cancer risks from exposure to radon progeny in mines and dwellings."
3.	Carcinogenesis 06/01/2014 - "Biophysical modelling of the effects of inhaled radon progeny on the bronchial epithelium for the estimation of the relationships applied in the two-stage clonal expansion model of carcinogenesis." 01/01/2014 - "Various biological models, including cultured cells and animals, have been found useful for studying the carcinogenesis effects of radon progeny alpha particles. " 02/01/1995 - "In spite of extensive efforts, no potential explanation for the discrepancy other than failure of the linear-no threshold theory for carcinogenesis from inhaled radon decay products could be found." 02/01/1995 - "Test of the linear-no threshold theory of radiation carcinogenesis for inhaled radon decay products." 01/01/1990 - "A mathematical formulation of a two-mutation model for carcinogenesis, which includes the recessive oncogenesis model as a special case, was fitted to data from a large experimental study in which rats exposed to radon daughters developed malignant lung tumors. "
4.	Stomach Neoplasms (Stomach Cancer) 01/01/2000 - "From the Silica Monograph, the research implications suggest that laboratory and epidemiology studies would be useful focusing on mixtures of hazards where silica is a significant component of the respirable environment: in coal mining (which has an excess of gastric cancers) with variations in silica exposure; in uranium mining where there is silica dust plus radon decay products, in foundries and steel-making plants where silica exposure is common as are other carcinogenic hazards; in agriculture where dusty farming may be common, and comparisons are needed with other polymorphs of silica, including amorphous quartz. "
5.	Leukemia 04/01/2006 - "Moreover, the study does not support the hypothesis of an association between exposure to short-lived radon progeny and leukemia risk." 04/01/2006 - "Using conditional logistic regression models, a dose-response relationship between leukemia risk and radon progeny could not be confirmed. "

Related Drugs and Biologics

1.	Radon
2.	Silicon Dioxide (Silica)
3.	Uranium
4.	Smoke
5.	Quartz
6.	Codon (Codons)
7.	Arsenic
8.	Radon Daughters
9.	Metals
10.	Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)

Related Therapies and Procedures

1.	Therapeutics
2.	Artificial Respiration (Mechanical Ventilation)
3.	Aftercare (After-Treatment)