Platinum Compounds (Compounds, Platinum)

03/01/2015 - "For more than three decades, platinum compounds have been the first line treatment for a wide spectrum of solid tumors. "
02/01/1992 - "The demonstration of possible synergistic activity between platinum compounds and radiation therapy also has prompted considerable interest, as such a combined-modality approach offers the potential for improved quality of life in patients with head and neck cancers. "
08/01/2010 - "ALC was effective in enhancing the antitumor potential of platinum compounds in wild-type p53 tumors. "
08/01/2002 - "In chemoradiotherapy, drugs effective against primary tumors are selected, platinum compounds often being key drugs. "
12/28/2009 - "Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting."

09/01/1987 - "From these results, these two platinum compounds seemed to be effective against human gastric carcinomas."
02/01/1982 - "(3) Basic studies of transplantable human prostatic carcinoma in nude mice and susceptibility testing of several platinum compounds (author's transl)]."
03/01/2008 - "Modulation of survival pathways in ovarian carcinoma cell lines resistant to platinum compounds."
02/28/2008 - "Ovarian carcinomas with mutations in the tumour suppressor BRCA2 are particularly sensitive to platinum compounds. "
09/01/2003 - "The platinum compounds are the most active agents in the treatment of ovarian carcinoma. "

01/01/1999 - "Prospective randomised trials have failed to demonstrate that doubling the dose of platinum compounds increases survival in patients with advanced ovarian cancer. "
02/01/2014 - "Citoreductive surgery associated to platinum compounds HIPEC is feasible and relatively safe in recurrent and primary PC from ovarian cancer. "
07/28/2006 - "Differential processing of antitumour-active and antitumour-inactive trans platinum compounds by SKOV-3 ovarian cancer cells."
11/01/2005 - "Platinum compounds are the most effective drugs in the fight against ovarian cancer. "
08/01/2003 - "This suggests that ovarian cancers that overexpress MDM2 may be amenable to treatment with platinum compounds."

12/01/2004 - "Addition of platinum compounds to a new agent in patients with advanced non-small-cell lung cancer: a literature based meta-analysis of randomised trials."
03/10/2013 - "In non-small-cell lung cancer, platinum compounds represent the cornerstone of systemic therapy. "
05/01/2002 - "The value of platinum compounds in non-small-cell lung cancer."
12/01/1998 - "Are platinum compounds mandatory in the treatment of metastatic non-small cell lung cancer?"
09/01/2005 - "Combination of chemotherapy without platinum compounds in the treatment of advanced non-small cell lung cancer: a systematic review of phase III trials."

12/21/2015 - "In clinical practice, metal-based drugs are represented by platinum compounds, which are constituents of a wide variety of chemotherapeutic regimens, and are only rarely active against tumour metastases unless they are combined with drugs that target specific pathways characterizing the malignancy of the tested tumour. "
01/01/1998 - "In cisplatin study a pain response was observed in 10 of 12 (83%) evaluable patients, 5/6 in Arm 1 and 4/6 in Arm 2. Low-dose platinum compounds seem to enhance the effects of 89Sr radioisotope therapy on pain from bone metastases without relevant hematological toxicity."
04/01/1993 - "An incidence of cerebral metastases secondary to epithelial ovarian cancer as high as 11.6% has been reported in small series and related to the prolonged survival of ovarian cancer patients treated with platinum compounds (Hardy, J. "
07/15/1994 - "Intensive chemotherapy using cyclophosphamide, platinum compounds, epipodophyllotoxins, doxorubicin, and vincristine was effective in orbital involvement of retinoblastoma even with associated extra-CNS metastases. "
05/01/2004 - "Ten patients with hormone relapsing metastatic prostate cancer who had been previously treated with extensive radiotherapy for metastasis and chemotherapy including docetaxel and platinum compounds were evaluated to determine the safety and efficacy of docetaxel with high-dose calcitriol and platinum compound combination intra-arterial chemotherapy. "