Hydroxyl Radical

01/01/2019 - "Furthermore, during the exfoliation process of the Fe3O4 nanocrystals, the catalytic activity of the Fe3O4 nanocrystals toward a Fenton-like reaction within cancer cells could be improved because of the increase in specific surface area, which led to the generation of highly toxic hydroxyl radicals and induced HeLa cell apoptosis. "
11/27/2018 - "Finally, we demonstrated the tumor site-specific production of highly toxic hydroxyl radicals for enhanced anticancer therapeutic efficacy while minimizing systemic toxicity in mice."
12/01/2008 - "The introduction of an uncharged hydroxyl group (beta3hSer) improved the biodistribution, resulting in significantly better tumor-to-tissue ratios. "
11/09/2022 - "However, the insufficient intracellular H2O2 level and inefficiency of catalysts in tumor cells limit the production of enough toxic hydroxyl radicals (˙OH) to achieve satisfactory efficacy for CDT. "
02/05/2022 - "Alternative acylations on the hydroxyl groups essential for cell toxicity by chemosynthesis produced compounds with improved anti-tumor activities and pharmacokinetics. "

04/01/2011 - "A novel electron paramagnetic resonance spin-probe technique demonstrates the relation between the production of hydroxyl radicals and ischemia-reperfusion injury."
06/01/1996 - "Hydroxyl radical scavengers may be useful in reducing neuronal damage associated with ischemia-reperfusion injury."
01/05/1993 - "We attribute the toxicity of free SOD in hearts subjected to ischemia-reperfusion injury to the production of hydroxyl radicals as a result of the increased Fenton reaction. "
01/01/1988 - "The role of the hydroxyl radical in ischemia/reperfusion injury, and its proposed mechanism, is discussed."
09/01/1993 - "We measured ischemia-reperfusion injury and hydroxyl radical production following 90 min of either air-ventilated, N2-ventilated, or nonventilated ischemia in an isolated rabbit lung preparation. "

11/01/2023 - "Acting as a POD mimic under an acidic bacterial microenvironment, FeCP catalyzes H2 O2 into hydroxyl radicals to prevent infection. "
05/20/2022 - "These metabolites generated hydroxyl radicals to disrupt the subcellular components of the algal cells and to make the algal cells more susceptible to the infection. "
07/31/2019 - "When the nanosystem gathered at the infection site, Hyal secreted by bacteria could degrade the HA capping and trigger the release of AA and then generated hydroxyl radicals (•OH) in situ by the catalysis of MoS2. "
08/01/2012 - "The present study aimed to evaluate in vitro and in vivo antibacterial activity of hydroxyl radical generation system by photolysis of H(2)O(2), which is a new disinfection system for the treatment of oral infection diseases such as periodontitis developed in our laboratory. "
04/01/2022 - "HCQ is derived from CQ by adding a hydroxyl group into it and is a less toxic derivative of CQ for the treatment of COVID-19 infection because it is more soluble. "

01/01/2016 - "This study revealed that GO adhered to and enveloped the chorion of zebrafish embryos mainly via hydroxyl group interactions, blocked the pore canals of the chorionic membrane, and caused marked hypoxia and hatching delay. "
11/01/2022 - "Hypoxia-Inducible Factor-Prolyl Hydroxyl Domain Inhibitors: From Theoretical Superiority to Clinical Noninferiority Compared with Current ESAs?"
02/01/2020 - "Furthermore, C60@GNPs hybrid could efficiently generate hydroxyl radicals under NIR light excitation even in the hypoxia condition. "
04/01/2019 - "Hydroxyl scavenging capacity varied across temperature treatment and control/hypoxia groups. "
08/01/2003 - "In contrast, changes mediated by chemical hypoxia were not affected by hydroxyl radical scavengers. "

04/19/2006 - "During cerebral ischemia, the hydroxyl radical levels were elevated in rats and animals displayed severe neuronal loss. "
05/01/2000 - "Increases in hydroxyl radical production have been used as evidence of oxidative stress in cerebral ischemia/ reperfusion. "
05/01/2000 - "Hydroxyl radical production in the cortex and striatum in a rat model of focal cerebral ischemia."
01/01/1996 - "Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats."
09/08/1995 - "Detection of hydroxyl radicals in rat striatum during transient focal cerebral ischemia: possible implication in tissue damage."