Neuroectodermal Tumors (Neuroectodermal Tumor)

Malignant neoplasms arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells.
Also Known As:
Neuroectodermal Tumor; Tumor, Neuroectodermal; Tumors, Neuroectodermal
Networked: 187 relevant articles (4 outcomes, 19 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Melanoma (Melanoma, Malignant)
3. Sarcoma (Soft Tissue Sarcoma)
4. Squamous Cell Carcinoma (Epidermoid Carcinoma)
5. Neuroblastoma


1. Cheung, Nai-Kong V: 3 articles (05/2015 - 10/2004)
2. Frühwald, Michael C: 2 articles (08/2013 - 12/2009)
3. Hasselblatt, Martin: 2 articles (08/2013 - 12/2009)
4. Boyd, Marie: 2 articles (09/2011 - 08/2008)
5. Mairs, Rob J: 2 articles (09/2011 - 08/2008)
6. Pagnan, Gabriella: 2 articles (01/2010 - 12/2004)
7. Ponzoni, Mirco: 2 articles (01/2010 - 12/2004)
8. Pastorino, Fabio: 2 articles (01/2010 - 12/2004)
9. Gross, Nicole: 2 articles (04/2009 - 04/2009)
10. Meier, Roland: 2 articles (04/2009 - 04/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neuroectodermal Tumors:
1. AntigensIBA
2. betulinic acidIBA
3. AntibodiesIBA
4. Interleukin-2 (IL2)IBA
5. imatinib (Gleevec)FDA Link
6. EnzymesIBA
7. Phosphopyruvate Hydratase (Enolase)IBA
04/01/2001 - "Immunohistochemical studies showed the tumor cells were ectodermal in origin but not endodermal, based on three diagnostic features of neuroectodermal tumors 1) pseudorosette formation noted under light microscopy, 2) finding of a small number of dense core neurosecretory granules on electron microscopy, and 3) positive immunostaining for both neuronal specific enolase and protein gene product 9.5. "
12/15/1988 - "Pretreatment samples from 24 children with neuroectodermal tumors (two ganglioneuromas, 22 neuroblastomas) and from 106 others with various tumors were submitted to the enzymatic determination of the serum neuron-specific enolase (NSE). "
01/01/1990 - "A number of laboratory studies that focus on biologic features such as neurotransmitter synthesis (adrenergic and noradrenergic catecholamines), neurotransmitter enzyme expression (dopamine beta hydroxylase, choline acetyl transferase), cytogenetics (homogeneously staining regions, double minute chromosomes, chromosome 1p deletions), molecular genetics (N-myc oncogene amplification and expression), and immunophenotype (surface epitopes such as HLA antigens and GD2 ganglioside and intracytoplasmic determinants such as neurofilament protein, synaptophysin, chromogranin, and neuron specific enolase) now enable the pathologist to predict clinical course in many cases and to distinguish bona fide neuroblastomas, regardless of age, site, or histologic appearance, from a host of related but distinctly separate neuroectodermal tumor entities with apparent different histogenesis, treatment sensitivity, and prognosis."
02/01/1991 - "We studied two cases of pigmented neuroectodermal tumor of infancy (PNTI) by routine light microscopy and immunohistochemistry on formalin fixed, paraffin embedded tissues using antibodies to HMB-45 "melanoma associated" antigen, S-100 protein, neuron specific enolase (NSE), Leu-7 antigen, chromogranin, epithelial membrane antigen, collagen Type IV, alpha-fetoprotein and muscle-specific actin and to the intermediate filaments cytokeratin (CK), vimentin, desmin and neural filaments. "
8. Bromodeoxyuridine (BrdU)IBA
9. Proteins (Proteins, Gene)IBA
10. Monoclonal AntibodiesIBA

Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Transplantation (Transplant Recipients)
3. Intravenous Infusions
4. Immunotherapy
5. Drug Therapy (Chemotherapy)