Kleine-Levin Syndrome (Syndrome, Kleine-Levin)

A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)
Also Known As:
Syndrome, Kleine-Levin; Familial Hibernation (Kleine-Levin) Syndrome; Familial Kleine-Levin Syndrome; Kleine-Levin Hibernation Syndrome; Kleine-Levin-Critchley Syndrome; Familial Kleine Levin Syndrome; Hibernation Syndrome, Kleine-Levin; Kleine Levin Critchley Syndrome; Kleine Levin Hibernation Syndrome; Kleine Levin Syndrome; Kleine-Levin Syndrome, Familial; Periodic Hypersomnia; Periodic Hypersomnias; Syndrome, Familial Kleine-Levin; Syndrome, Kleine-Levin Hibernation; Syndrome, Kleine-Levin-Critchley; Hypersomnia, Periodic
Networked: 61 relevant articles (5 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Epilepsy (Aura)
2. Disorders of Excessive Somnolence (Hypersomnia)
3. Kleine-Levin Syndrome (Syndrome, Kleine-Levin)
4. Prader-Willi Syndrome (Syndrome, Prader-Willi)
5. Narcolepsy


1. Dauvilliers, Yves: 3 articles (01/2015 - 12/2006)
2. Dhossche, Dirk M: 3 articles (04/2014 - 11/2010)
3. Rout, Ujjwal K: 2 articles (04/2014 - 12/2010)
4. Billiard, Michel: 2 articles (08/2011 - 12/2006)
5. Leu-Semenescu, Smaranda: 1 article (11/2015)
6. Le Corvec, Thibault: 1 article (11/2015)
7. Mayer, Geert: 1 article (11/2015)
8. Groos, Elisabeth: 1 article (11/2015)
9. Golmard, Jean-Louis: 1 article (11/2015)
10. Lavault, Sophie: 1 article (11/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Kleine-Levin Syndrome:
1. LithiumIBA
2. Lithium Carbonate (Eskalith)FDA LinkGeneric
3. Carbamazepine (Tegretol)FDA LinkGeneric
4. gabapentin (Neurontin)FDA LinkGeneric
5. Antidepressive Agents (Antidepressants)IBA
6. Anticonvulsants (Antiepileptic Drugs)IBA
7. tranilast (N 5')IBA
8. Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
9. modafinil (armodafinil)FDA Link
10. orexins (orexin)IBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Phototherapy (Light Therapy)