Radiation Pneumonitis

12/01/2006 - "She improved immediately, but subsequently the radiation pneumonitis relapsed three times when the steroid medication was stopped. "
03/01/2003 - "The steroid was administrated due to the radiation pneumonia, and the complication was improved. "
10/20/2023 - "One patient (lung dose, 27.8 Gy) developed radiation pneumonitis requiring transient steroid treatment. "
11/11/2014 - "Six patients (9%) developed radiation pneumonitis required by steroid administration. "
09/01/2013 - "She recently developed radiation pneumonitis, which was managed conservatively, and she did not require steroids. "

04/17/1999 - "The two types of radiation pneumonitis can be treated successfully with corticosteroids. "
09/01/1991 - "Corticosteroids have previously been found to be protective against the mortality of radiation pneumonitis in mice, even when given well after lethal lung irradiation. "
01/01/2023 - "He subsequently developed radiation pneumonitis and received corticosteroids. "
03/14/2013 - "In a patient with locally advanced NSCLC that progressed despite chemoradiation, radiation pneumonitis and subsequently cavitary disease developed following the administration of corticosteroids. "
09/01/2006 - "Grade 3-4 radiation pneumonitis occurred in two patients (7.7%) and was treated with corticosteroids. "

04/04/2022 - "In clinical practice, the effect of durvalumab and radiation pneumonitis (RP) on survival after intensity-modulated radiotherapy (IMRT) is not fully understood. "
01/15/2022 - "However, a major concern about administration of durvalumab after CCRT is whether the incidence of symptomatic radiation pneumonitis (RP) may increase or not. "
01/01/2020 - "However, careful selection of candidates for durvalumab treatment and active surveillance and appropriate management for radiation pneumonitis are needed."
01/01/2020 - "The incidence of grade 3 radiation pneumonitis was 14.3 % in the durvalumab group versus 2.5 % in the observation group. "
01/01/2020 - "However, radiation pneumonitis occurred more frequently in the durvalumab group, especially within 3-6 months after CCRT. "

05/20/2018 - "These cytokines can also be used as bio-markers to predict the occurrence of radiation pneumonitis. "
05/20/2018 - "The main manifestations of radiation pneumonitis are injury of alveolar epithelial and endothelial cells, abnormal expression of cytokines, abnormal proliferation of fibroblasts and synthesis of fibrous matrix. "
05/01/2010 - "Contrary to acute radiation pneumonitis, RF was not correlated to cytokine variations during 3D-RT."
08/06/2008 - "Cytokine plasma levels: reliable predictors for radiation pneumonitis?"
12/01/2005 - "No association was found between baseline cytokine levels and the risk of radiation pneumonitis. "

03/01/2001 - "In contrast, we did not detect a significant correlation between plasma TNFalpha and radiation pneumonitis. "
07/18/2017 - "Early release of tumor necrosis factor-alpha (TNF-α) during radiotherapy of thoracic cancers plays an important role in radiation pneumonitis, whose inhibition may provide lung radioprotection. "
10/01/2011 - "The reduced level of radiation pneumonitis (as monitored by breathing rate changes) in animals knocked out for TNF-alpha suggests that this cytokine plays a significant role in inducing inflammation in lung following irradiation. "
12/01/2005 - "The most serious acute radiation pneumonia was seen in the 5th week and pulmonary fibrosis was remarkable in the 26th week in the simple irradiation group, with the expressions of TNF-alpha and TGF-beta at different time phases enhanced significantly (P < 0.01). "
12/01/2007 - "Plasma level of TNF-alpha and ratio of IL-10/ TNF-a could be the practicable indexes for estimating the susceptibility of acute radiation pneumonia; SFI can regulate the network of cytokine, and thus be effective in preventing and treating radiation pneumonitis."

06/01/2003 - "Other subgroups analyzed, including smokers, nonsmokers, those with and without endobronchial disease, as well as those free from radiation pneumonitis, also showed no significant change in the clearance of the aerosol. "
06/01/2003 - "In such patients, clearance of the aerosol does not predict the development of radiation pneumonitis."
06/01/2003 - "Can 99mTc-DTPA aerosol scanning predict radiation pneumonitis?"
06/01/1975 - "This study was performed to evaluate bronchopulmonary lavage and chelation therapy as a treatment method to prevent the development of radiation pneumonitis after inhalation of a radioactive aerosol. "
12/01/1999 - "The deterministic effects observed for both of these relatively insoluble aerosols were lymphopenia, fibrosis, atrophy of the lung-associated lymph nodes, and radiation pneumonitis. "

01/01/2020 - "To determine the role of NLRP3 inflammasome activation in low-dose radiation-induced radiation pneumonitis (RP) and to assess whether inhibition or deletion of the NLRP3 inflammasome is critical for conferring protection against RP. "
03/01/2021 - "Erratum to: Xiaoyu Li, Youling Gong, Dan Li, et al. Low-Dose Radiation Therapy Promotes Radiation Pneumonitis by Activating NLRP3 Inflammasome. "
01/01/2020 - "Low-Dose Radiation Therapy Promotes Radiation Pneumonitis by Activating NLRP3 Inflammasome."
10/01/2016 - "The Influence of Radiotherapy on AIM2 Inflammasome in Radiation Pneumonitis."
10/01/2016 - "This study aims to investigate the influence of radiotherapy on absent in melanoma 2 (AIM2) inflammasome in radiation pneumonitis (RP). "

01/01/2022 - "Treatment with lisinopril improved survival during radiation pneumonitis (P = .0004). "
01/01/2019 - "The purpose of this study was to define echocardiographic features in rats at two times after irradiation, the first before lethal radiation pneumonitis (50 d) and the second after recovery from pneumonitis but before lethal radiation nephropathy (100 d), and to determine the actions of the angiotensin-converting enzyme inhibitor lisinopril. "

07/01/1993 - "Histological examination of the irradiated lungs indicated that these acute changes detected by CT were associated with the exudative and edematous phases of radiation pneumonitis, and that captopril reduced the severity of these changes. "
07/01/2012 - "In the current study we determined the dose modifying factors (DMFs) of captopril for mitigation of parameters of radiation pneumonitis. "
07/01/1993 - "Radiation pneumonitis in rats and its modification by the angiotensin-converting enzyme inhibitor captopril evaluated by high-resolution computed tomography."

01/01/2019 - "Further investigation is required to clarify and expand on the benefits of nebulized acetylcysteine for patients with radiation pneumonitis."
01/01/2019 - "We prospectively enrolled and followed 25 patients with radiation pneumonitis who used nebulized acetylcysteine three times a day for 12 weeks. "
01/01/2019 - "This study investigated the benefits of nebulized acetylcysteine for lung cancer patients diagnosed with radiation pneumonitis after radiotherapy. "
01/01/2019 - "Efficacy of nebulized acetylcysteine for relieving symptoms and reducing usage of expectorants in patients with radiation pneumonitis."
01/01/2019 - "The beneficial effects of nebulized acetylcysteine for patients with radiation pneumonitis included relieving sputum severity and minimizing expectorant use, especially in severe cases. "

02/01/1985 - "On the low-dose regimen, one patient achieved partial response with IFN alone (duration, 12 weeks); of five evaluable patients three achieved complete remission and two partial remission to IFN-radiotherapy, and one of the three complete responders to IFN-radiotherapy died of severe radiation pneumonitis at 21 weeks from the start of IFN treatment. "
01/01/2021 - "Purpose: Radiation pneumonitis (RP) frequently occurs during a treatment course of chest radiotherapy, which significantly reduces the clinical outcome and efficacy of radiotherapy. "
07/01/2022 - "Grade 2 and higher radiation pneumonitis (RP2) is a potentially fatal toxicity that limits efficacy of radiation therapy (RT). "
08/01/2021 - "He developed radiation pneumonitis after completion of radiotherapy, which responded well to symptomatic treatment. "
02/01/2006 - "Seventy percent of the patients (16/23) experienced improved perfusion at 40 - 50 Gy. > or = grade 2 radiation pneumonitis was observed in 12 patients (38.7%) in the whole group, with 6 in those with grade 1 perfusion defects and another 6 in > or = grade 2 group, respectively; Of the 23 patients who had had both pre- and post-radiotherapy SPECT perfusion scan, 5 > or = grade 2 radiation pneumonitis occurred in the 16 perfusion-improved patients and 3 in the 7 unimproved patients. "

12/01/2004 - "Measuring KL-6 serum levels is also useful in assessing the efficacy of therapy for radiation pneumonitis."
07/01/2022 - "The Zengxiao Jiandu decoction adjunctive therapy, as compared to DCCRT alone, reduced grade ≥3 radiation pneumonitis, improved the completion rate of DCCRT, and prolonged PFS for unresectable LA-NSCLC. "
11/01/2020 - "This study aimed to investigate risk factors for radiation pneumonitis (RP) caused by electron beam (EB) boost irradiation during breast-conserving therapy. "
01/01/2011 - "Our study suggests that HR genetic polymorphisms, particularly RAD51 -135G>C, may influence overall survival and radiation pneumonitis in NSCLC patients treated with definitive radio(chemo)therapy. "
04/11/2021 - "The patient developed acute radiation pneumonitis during the initial therapy, which resolved at 6 months after the CyberKnife treatment. "

11/01/2012 - "Studies reporting crude incidence or odds ratios (OR) for radiation pneumonitis vs. age, disease location, smoking status, chemotherapy schedule or comorbidity were included. "
07/01/2010 - "Some studies demonstrated that preexisting pulmonary lung dysfunction, tumour location in lower lobes, use of concurrent chemotherapy could increase the risk of radiation pneumonitis. "
09/01/2005 - "chemotherapy regimen and dose) have been proposed as potential predictors of the risk of radiation pneumonitis, but these have not been consistently demonstrated across different studies. "
01/01/1997 - "However, future studies using protracted radiosensitizing chemotherapy should be approached cautiously in light of the high incidence of severe radiation pneumonitis encountered in this trial."
01/01/2022 - "The final multivariate model incorporated sex, smoking history, histology (including EGFR mutation status), TNM stage, planning target volume, chemotherapy sequence and radiation pneumonitis grade. "

07/30/2014 - "The rate of radiation pneumonitis (RP) for patients receiving chemoradiotherapy has been various across studies. "
08/01/2012 - "Scoring of radiation pneumonitis (RP), a dose-limiting toxicity after thoracic radiochemotherapy, is subjective and thus inconsistent among studies. "
07/01/2023 - "Ipsilateral lung dose as a correlative measure for radiation pneumonitis in patients treated with definitive concurrent radiochemotherapy."
03/17/2021 - "Patients with LS-SCLC and ILAs who were treated with chemoradiotherapy had both the possibility of long-term survival and risk of radiation pneumonitis."
03/17/2021 - "ILAs were found to be a predictive factor for radiation pneumonitis in patients with LS-SCLC treated with chemoradiotherapy. "

02/01/2015 - "This study compares physical dose characteristics and anticipated risks of radiation pneumonitis (RP) among three SBRT modalities: robotic radiosurgery (RR), helical tomotherapy (HT) and volumetric modulated arc therapy (VMAT). "
12/01/2021 - "Volumetric modulated arc therapy has potential benefits to reduce the risk of ≥ grade 2 radiation pneumonitis."
12/01/2021 - "The use of volumetric modulated arc therapy was a significant factor for ≥ grade 2 radiation pneumonitis (HR:0.32, 95% CI: 0.15-0.65, P = 0.0017) in addition to lung V20Gy (≥ 24%, HR:5.72 (95% CI: 2.87-11.4), P < 0.0001) and total dose (≥ 70 Gy, HR:2.64 (95% CI: 1.39-5.03), P = 0.0031) even after adjustment by multivariate analysis. "
12/01/2013 - "Escalation of dose per fraction was performed according to patients' stratified risk for radiation pneumonitis with total RT doses ranging from 57 to 85.5 Gy in 25 daily fractions over 5 weeks using intensity-modulated radiotherapy. "
12/01/2021 - "The purpose of this study was to identify the factors that caused ≥ grade 2 radiation pneumonitis and evaluate the impact of using volumetric modulated arc therapy on the incidence of ≥ grade 2 radiation pneumonitis by comparing three-dimensional conformal radiation therapy. "