Thoracic Aortic Aneurysm

An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.

Also Known As:

Networked: 643 relevant articles (26 outcomes, 39 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Abdominal Aortic Aneurysm
2.	Aneurysm (Aneurysms)
3.	Marfan Syndrome (Marfan's Syndrome)
4.	Spinal Cord Injuries (Spinal Cord Injury)
5.	Pathologic Constriction (Stenosis)

Experts

1.	Coselli, Joseph S: 12 articles (02/2015 - 03/2002)
2.	Ikonomidis, John S: 8 articles (05/2013 - 10/2006)
3.	Kawaharada, Nobuyoshi: 7 articles (09/2014 - 01/2002)
4.	Kurimoto, Yoshihiko: 7 articles (09/2014 - 04/2005)
5.	Chiesa, Roberto: 7 articles (09/2014 - 07/2002)
6.	LeMaire, Scott A: 7 articles (04/2013 - 03/2002)
7.	Spinale, Francis G: 7 articles (02/2012 - 10/2006)
8.	Bavaria, Joseph E: 6 articles (02/2014 - 10/2005)
9.	Stroud, Robert E: 6 articles (05/2013 - 10/2006)
10.	Jones, Jeffrey A: 6 articles (05/2013 - 01/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Thoracic Aortic Aneurysm:

1.	Doxycycline (Vibramycin)FDA LinkGeneric 08/01/2010 - "We hypothesized that a combination of losartan potassium and doxycycline would offer better secondary prevention treatment than would single-drug therapy to manage thoracic aortic aneurysm. " 08/01/2010 - "Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm in Marfan syndrome." 04/25/2008 - "Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in marfan syndrome through the inhibition of matrix metalloproteinase-2 and -9." 08/01/2010 - "Losartan potassium and doxycycline combined completely prevented thoracic aortic aneurysm and improved elastic fiber organization, also downregulating matrix metalloproteinases 2 and 9 and transforming growth factor beta and normalizing aortic contractile and relaxation functions to control values. "
2.	Lactic AcidFDA LinkGeneric 01/01/1997 - "The reduction in CSF lactate correlated with the methods used to protect the spinal cord during thoracoabdominal aortic aneurysm surgery and was associated with better outcome. " 01/01/1997 - "Changes in cerebrospinal fluid pressure and lactate concentrations during thoracoabdominal aortic aneurysm surgery." 02/01/2011 - "This study has the potential to elucidate the time course of early lactate level elevation during thoracoabdominal aortic aneurysm repair and its clinical use in predicting the development of postoperative spinal cord injury." 02/01/2011 - "The aim of this study was to evaluate the role of lactate as an early predictor of spinal cord injury during thoracoabdominal aortic aneurysm repair. " 01/01/1997 - "This study evaluated the effect of cerebrospinal fluid (CSF) drainage, with and without distal femoral perfusion or moderate hypothermia on blood and CSF lactate concentrations and CSF pressure during thoracoabdominal aortic aneurysm surgery. "
3.	Matrix MetalloproteinasesIBA 01/01/2013 - "Spatiotemporal expression of matrix metalloproteinases (MMPs) is regulated by the Ca2+-signal transducer S100A4 in the pathogenesis of thoracic aortic aneurysm." 04/01/2007 - "Matrix metalloproteinases and their endogenous inhibitors have been causally linked to ascending thoracic aortic aneurysm formation. " 10/01/2007 - "The role of matrix metalloproteinases and their tissue endogenous inhibitors has been documented in abdominal aortic aneurysms, but few articles have investigated their role after thoracic aortic aneurysm treatment. " 08/01/2010 - "This study was designed to establish a rat model of thoracic aortic aneurysm (TAA) by calcium chloride (CaCl(2))-induced arterial injury and to explore the potential role of a disintegrin and metalloproteinase (ADAM), matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) in TAA formation. " 10/01/2006 - "An important component of matrix remodeling during thoracic aortic aneurysm progression is the balance between matrix metalloproteinases and their endogenous inhibitors (tissue inhibitors of metalloproteinases). "
4.	Transforming Growth Factor beta (TGF-beta)IBA 02/01/2010 - "The transforming growth factor beta (TGF-beta) pathway regulates vascular remodeling and mutations in its receptor genes, TGFBR1 and TGFBR2, cause syndromes with thoracic aortic aneurysm (TAA). " 01/01/2009 - "Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis." 01/01/2008 - "Altered transforming growth factor-beta signaling in a murine model of thoracic aortic aneurysm." 01/01/2013 - "Angiotensin II Receptor Antagonism Reduces Transforming Growth Factor Beta and Smad Signaling in Thoracic Aortic Aneurysm." 06/01/2009 - "Previous studies have suggested a role for transforming growth factor (TGF) beta and its receptor in thoracic aortic aneurysm, but their role in abdominal aortic aneurysm (AAA) is unknown. "
5.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 08/01/2013 - "Limited studies evaluated the association between low-dose aspirin use and abdominal aortic aneurysm (AAA), thoracoabdominal aortic aneurysm (TAAA), and thoracic aortic aneurysm (TAA) treatment. " 03/01/2002 - "[Thoracic aortic aneurysm with chronic disseminated intravascular coagulation treated successfully with orally administered camostat mesilate, warfarin and aspirin]."
6.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 07/03/2015 - "Mmp17 proteolytic activity regulates vascular smooth muscle cell phenotype in the arterial vessel wall, and its absence predisposes to thoracic aortic aneurysm in mice. " 03/01/2012 - "Clinical outcome of staged versus combined treatment approach of hybrid repair of thoracoabdominal aortic aneurysm with visceral vessel debranching and aortic endograft exclusion." 07/01/2002 - "Repair of coexistent infrarenal and thoracoabdominal aortic aneurysm: combined endovascular and open surgical procedure with visceral vessel relocation." 01/01/2002 - "Descending or thoracoabdominal aortic aneurysm repair without intercostal vessel reconstruction using contrast magnetic resonance angiography: report of two cases." 10/01/2000 - "A thoracoabdominal aortic aneurysm involves vessel damage and wall weakening in the thoracic and abdominal segments of the aorta. "
7.	allogenic effect factor (AEF)IBA 12/21/2009 - "Thoracic aortic aneurysm is the most common cause of AEF. " 10/01/2009 - "We analyze a case of AEF as a late complication of stent-graft repair of a thoracic aortic aneurysm in a 74-year-old male. " 11/01/2005 - "A 58-year-old man was admitted for an aortoesophageal fistula (AEF) resulting from a thoracic aortic aneurysm. " 01/01/2004 - "We report a case of primary AEF caused by a descending thoracic aortic aneurysm, which was successfully treated with an endovascular stent-graft technique. " 08/01/2002 - "Thoracic aortic aneurysm is the most common etiology of primary AEF followed by, respectively, foreign body ingestion, esophageal malignancy, and postsurgical fistulization. "
8.	Heparin (Liquaemin)FDA LinkGeneric 08/01/2015 - "A Retrospective Examination of the Efficacy of Paravertebral Block for Patients Requiring Intraoperative High-Dose Unfractionated Heparin Administration During Thoracoabdominal Aortic Aneurysm Repair." 04/01/2005 - "One hundred of the 309 patients underwent repair of descending thoracic aortic aneurysm with heparin-coated circuits. " 05/01/1997 - "[A successful surgical treatment of dissecting thoracoabdominal aortic aneurysm using a heparin coated percutaneous cardiopulmonary support system]." 04/01/2005 - "We have performed descending thoracic aortic aneurysm repairs with partial cardiopulmonary bypass, including heparin-coated circuits. " 04/01/2005 - "Descending thoracic aortic aneurysm repair with the aid of partial cardiopulmonary bypass: heparin-coated circuits versus nonheparin-coated circuits."
9.	Dacarbazine (DIC)FDA LinkGeneric 12/01/2015 - "A 55-year-old man presented with DIC 10 months after TEVAR for chronic type B aortic dissection and descending thoracic aortic aneurysm. " 08/01/1995 - "We could performed the safe operation for thoracoabdominal aortic aneurysm complicated with pre-DIC. " 08/01/1990 - "When the underlying disorder has a rare incidence of DIC as in glioblastoma multiforme or thoracoabdominal aortic aneurysm, the possibility of DIC and the need for immediate initiation of replacement therapy should be recognized, although the mortality is very high because the underlying disorder cannot be eliminated quickly. " 03/01/2002 - "We describe a case of thoracic aortic aneurysm complicated by chronic disseminated intravascular coagulation (DIC). " 01/01/2009 - "We present the developmental course of DIC in a 70-year-old male patient who had a thoracoabdominal aortic aneurysm characterized by a progressive descending aortic aneurysm presenting as subcutaneous hemorrhage of acute onset. "
10.	Matrix Metalloproteinase 2 (Gelatinase A)IBA 04/01/2015 - "Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm." 08/31/2007 - "Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in the thoracic aortic aneurysm in Marfan syndrome." 12/01/2015 - "Increased levels of angiotensin II (Ang II) and activated matrix metalloproteinase 2 (MMP-2) produced by human aortic smooth muscle cells (human ASMCs) have recently been implicated in the pathogenesis of thoracic aortic aneurysm (TAA). " 10/01/2006 - "Thoracic aortic aneurysm size was determined by means of video micrometry, and immunoblotting was used to measure aortic matrix metalloproteinase 2, 8, 9, and 12 and tissue inhibitor of metalloproteinases 1 and 4 levels (expressed as a percentage of control values, n = 13). " 04/25/2008 - "Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in marfan syndrome through the inhibition of matrix metalloproteinase-2 and -9."

Therapies and Procedures

1.	Stents 01/01/2012 - "Multilayer stents can be used in thoracoabdominal aortic aneurysm, with positive results." 10/01/2005 - "Patients in thoracic aortic aneurysm stent trials from 1999 to 2004 were analyzed for paraplegic complications. " 12/02/2015 - "Despite his extremely high vascular surgery risk due to severely depressed cardiac function, stent grafting for thoracic aortic aneurysm was successfully performed. " 07/01/2015 - "The MFM stent could be an alternative treatment for saccular thoracic aortic aneurysm in high-risk patients but should not be used indiscriminately when other modalities of aortic repair are not feasible. " 01/01/2015 - "We describe a retrospective study of initial and long-term outcomes with an open stent grafting (OSG) with a Matsui-Kitamura stent for treating thoracic aortic aneurysm. "
2.	Transplants (Transplant) 09/01/2014 - "The aim of this study was to assess the safety and short-term effectiveness of a novel hybrid vascular graft used to address renal revascularization during open thoracoabdominal aortic aneurysm (TAAA) repair, performing a sutureless distal anastomosis. " 07/01/2004 - "The aim of this study was to describe the results of resection and graft replacement for type III and IV thoracoabdominal aortic aneurysm repair. " 01/01/2015 - "A 7-year-old boy with ascending thoracic aortic aneurysm (60×67 mm) underwent graft anastomosis from the sinotubular junction to the undersurface of the arch. " 09/01/2014 - "Use of a novel hybrid vascular graft for sutureless revascularization of the renal arteries during open thoracoabdominal aortic aneurysm repair." 06/01/2014 - "The patient had undergone graft placement for the management of a thoracic aortic aneurysm 14 days prior. "
3.	Cardiopulmonary Bypass (Heart-Lung Bypass) 03/01/2013 - "Cardiopulmonary bypass with hypothermic circulatory arrest can be safely used for thoracoabdominal aortic aneurysm repair, providing excellent protection against end-organ injury. " 04/01/2011 - "Cardiopulmonary bypass with hypothermic circulatory arrest can be safely used for thoracoabdominal aortic aneurysm repair, providing excellent protection against end-organ injury. " 03/01/2004 - "Our experience with hypothermic cardiopulmonary bypass and circulatory arrest for diffuse type thoracoabdominal aortic aneurysm confirms the safety and efficacy of this technique. " 12/01/2014 - "The conventional thoracoabdominal aortic aneurysm repair technique using cardiopulmonary bypass is a high-risk procedure. " 10/01/2014 - "A 74-year-old man with ruptured thoracoabdominal aortic aneurysm was scheduled for open surgical repair under partial cardiopulmonary bypass. "
4.	Deep Hypothermia Induced Circulatory Arrest 01/01/2012 - "During descending thoracic aortic and thoracoabdominal aortic aneurysm repairs, the use of deep hypothermic circulatory arrest results in improved postoperative adverse outcome rates compared with non-deep hypothermic circulatory arrest techniques. " 01/01/2015 - "This study aimed to report the outcomes of patients who underwent proximal thoracic aortic aneurysm surgery with open distal anastomosis technique but without cerebral perfusion, instead under deep hypothermic circulatory arrest. " 01/01/2015 - "These results demonstrate that open distal anastomosis under less than 30 minutes of deep hypothermic circulatory arrest without antegrade or retrograde cerebral perfusion and cannulation of the aneurysmatic segment is a safe and reliable procedure in patients undergoing proximal thoracic aortic aneurysm surgery." 11/01/2014 - "Surgical repair of a descending thoracic and thoracoabdominal aortic aneurysm (DTA/TAAA) involving the distal arch is challenging and requires either deep hypothermic circulatory arrest (DHCA) or crossclamping of the distal arch. " 12/01/2010 - "All patients (n = 343) who underwent surgical replacement of descending thoracic aortic or thoracoabdominal aortic aneurysm with deep hypothermic circulatory arrest from 1995 to 2009 were included. "
5.	Endovascular Procedures 01/01/2009 - ": Out of consecutive 203 patients with descending thoracic aortic aneurysm, 89 (43.8%) received endovascular treatment [mean age, 68 ± 8 years; range, 29-82; male, 79 (88.7%); female, 10 (11.3%)] without using angiography during the endovascular procedure. " 12/01/2008 - "Hybrid surgical-endovascular procedure was conducted in a 46-year-old male with extensive thoracic aortic aneurysm. " 04/01/2008 - "We report the case of a 72-year-old woman with thoracoabdominal aortic aneurysm who underwent hybrid surgical and endovascular procedure. " 03/01/2005 - "A combined surgical and endovascular procedure for thoracic aortic aneurysm in a high risk patient." 01/01/2005 - "We report a case of thoracoabdominal aortic aneurysm that was repaired using a hybrid approach: surgery followed by an endovascular procedure. "