Abdominal Aortic Aneurysm

An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.

Also Known As:

Networked: 3798 relevant articles (93 outcomes, 411 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Aneurysm (Aneurysms)
2.	Rupture
3.	Fistula
4.	Aortic Aneurysm (Aneurysm, Aortic)
5.	Thoracic Aortic Aneurysm

Experts

1.	Golledge, Jonathan: 51 articles (02/2015 - 06/2005)
2.	Daugherty, Alan: 41 articles (01/2016 - 03/2003)
3.	Upchurch, Gilbert R: 31 articles (12/2015 - 07/2002)
4.	Cassis, Lisa A: 28 articles (08/2015 - 03/2003)
5.	Norman, Paul E: 27 articles (01/2015 - 03/2007)
6.	Shi, Guo-Ping: 24 articles (01/2016 - 02/2006)
7.	Thompson, Robert W: 24 articles (10/2014 - 02/2002)
8.	Marin, Michael L: 22 articles (06/2014 - 01/2002)
9.	Lindholt, Jes S: 20 articles (01/2016 - 12/2002)
10.	Dalman, Ronald L: 19 articles (01/2015 - 12/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Abdominal Aortic Aneurysm:

1.	Pancreatic Elastase (Elastase)IBA 05/01/1998 - "The intraluminal elastase perfusion model has been proven to be potentially effective in producing abdominal aortic aneurysms (AAA) in rodents, yet has produced unpredictable results in larger animals. " 05/01/1997 - "The intraluminal elastase perfusion model has been proved to be potentially effective in producing abdominal aortic aneurysm in rodents, but it produced unpredictable results in larger animals. " 11/01/2015 - "Regarding "Elastase inhibitor AZD9668 treatment prevented progression of experimental abdominal aortic aneurysms"." 11/07/2014 - "Disruption of TGF-β signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm." 11/01/2014 - "Self-healing phenomenon was found in the periarterial elastase-induced abdominal aortic aneurysm (AAA) in rabbit. "
2.	Polyethylene Terephthalates (Polyethylene Terephthalate)IBA 09/01/2014 - "Saccular abdominal aortic aneurysms were made with Dacron patch in eight dogs. " 09/01/2002 - "The purpose of this study was to investigate the postoperative inflammatory reactions to albumin-coated Dacron grafts (ACGs), which are used in the repair of abdominal aortic aneurysm (AAA). " 05/01/1996 - "The authors report the experience of a single investigational center involving two Phase I and a Phase II clinical trials approved by the Food and Drug Administration (FDA) for the transfemoral implantation of woven Dacron grafts for abdominal aortic aneurysms. " 03/01/2008 - "He had previously undergone surgical treatment for an infrarenal abdominal aortic aneurysm, which was managed with a terminal-terminal Dacron tube graft. " 12/01/2006 - "Six years previously she had undergone repair of the thoraco-abdominal aortic aneurysm with a 24-mm knitted Dacron graft for type B chronic aortic dissection. "
3.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 01/01/2006 - "These data suggest that NO donors may be beneficial in decreasing MMP-9 levels and might serve to inhibit MMP-9-dependent vessel wall remodeling seen during abdominal aortic aneurysm formation." 04/01/2013 - "The aim of this study was to demonstrate the effectiveness of selected methods of experimental induction of abdominal aortic aneurysm in swine and to adapt the EMG examination (electromyography) to record the vessel wall changes. " 01/01/2015 - "Imaging vessel wall biology to predict outcome in abdominal aortic aneurysm." 06/01/2014 - "To investigate the feasibility and reproducibility of dynamic contrast-enhanced MRI (DCE-MRI) to quantify abdominal aortic aneurysm (AAA) vessel wall enhancement dynamics which may reflect the amount of wall microvasculature. " 12/01/2013 - "Formation of abdominal aortic aneurysms is a progressive inflammatory process that involves infiltration and differentiation of monocytes in the vessel wall, proliferation and migration of smooth muscle cells, and eventually the degradation of the internal elastic lamina, which leads to outward vascular remodeling and distension of the vessel. "
4.	Dihydrotachysterol (AT 10)IBA 11/17/2009 - "ACP Journal Club: Screening for abdominal aortic aneurysm (AAA) in men 65 to 74 years of age was cost-effective for AAA mortality at 10 years." 07/01/2002 - "The study was an update at 10 years of a randomized trial of the efficacy of screening for abdominal aortic aneurysm (AAA). "
5.	Angiotensin IIIBA 01/01/2015 - "Since the initial publication in 2000, Angiotensin II-infused mice have become one of the most popular models to study abdominal aortic aneurysm in a pre-clinical setting. " 01/01/2015 - "Experimental studies suggest that angiotensin II plays a central role in the pathogenesis of abdominal aortic aneurysm. " 11/01/2008 - "Hyperlipidimic mice administered angiotensin II have been used for the study of abdominal aortic aneurysms (AAAs). " 08/01/2007 - "The goal of the present study was to assess the importance of the 5-LO/LT pathway in angiotensin II (Ang II)-induced murine abdominal aortic aneurysm (AAA) formation. " 07/01/2015 - "Regulatory T cells (Tregs) protect mice from angiotensin II (Ang-II)-induced abdominal aortic aneurysms (AAA). "
6.	Biological Markers (Surrogate Marker)IBA 10/01/2010 - "Identification of biomarkers for the natural history of abdominal aortic aneurysms (AAA) holds the key to non-surgical intervention and improved selection for AAA repair. " 10/01/2014 - "Many studies have investigated the systemic and local expression of biomarkers in patients with abdominal aortic aneurysm (AAA). " 08/01/2014 - "To find potential biomarkers of abdominal aortic aneurysms (AAA), we performed a differential proteomic study based on human plasma-derived microvesicles. " 01/01/2010 - "The aim of this study was to determine plasma concentrations of Gas6 and sAxl in patients with abdominal aortic aneurysms (AAA) and to evaluate if Gas6 and sAxl can be used as biomarkers. " 01/01/2015 - "Proteomic approaches to identify circulating biomarkers in patients with abdominal aortic aneurysm."
7.	Doxycycline (Vibramycin)FDA LinkGeneric 06/01/2004 - "We created a novel continuous infusion system to evaluate the efficacy of juxta-aortic doxycycline delivery as a transitional step toward developing hybrid drug/device treatment strategies for abdominal aortic aneurysm (AAA) disease. " 12/17/2013 - "Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial." 09/01/2005 - "The purpose of this study was to determine the effect of low-dose doxycycline on matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP)-1 expression in the wall of abdominal aortic aneurysms. " 07/01/2002 - "The primary purpose of this study was to evaluate compliance, side effects, and safety associated with prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms (AAAs). " 07/01/2015 - "Response to the "letter regarding Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms"."
8.	CholesterolIBA 12/01/2010 - "Despite the absence of a relationship between cholesterol and abdominal aortic aneurysm (AAA) expansion, there is evidence from a number of studies to suggest that statin therapy may influence AAA expansion, presumably through pleiotropic effects. " 09/01/2011 - "As cholesterol crystals have also been found in the walls of patients with abdominal aortic aneurysms (AAA), it is possible that the NLRP3 inflammasome is involved in AAA and genetic variability within this protein complex could alter disease risk. " 03/01/2011 - "[Lethal cholesterol crystal embolization syndrome after operation for abdominal aortic aneurysm]." 07/01/2003 - "It is concluded that major cardiovascular risk factors--serum cholesterol, smoking, and blood pressure--in middle age relate significantly to risk of abdominal aortic aneurysm in persons surviving into older age." 03/01/2003 - "This investigation focused on 7 siblings to 2 brothers with abdominal aortic aneurysm (AAA), with respect to AAA, Chlamydia pneumoniae (CP) serology, serum cholesterol, and smoking habits. "
9.	Heparin (Liquaemin)FDA LinkGeneric 08/01/1990 - "Clinical application of heparin surface coated equipment during resection of thoraco-abdominal aortic aneurysms is showing promising results in 12 patients." 04/01/2013 - "'The use of heparin in patients with ruptured abdominal aortic aneurysms'." 10/01/2012 - "To use or not to use heparin during abdominal aortic aneurysm repair?" 04/01/2012 - "The use of systemic heparin in patients with ruptured abdominal aortic aneurysms (rAAAs) remains a contentious issue with no clear guidelines. " 04/01/2012 - "The use of heparin in patients with ruptured abdominal aortic aneurysms."
10.	Apolipoproteins E (ApoE)IBA 01/01/2012 - "In vivo imaging of macrophages during the early-stages of abdominal aortic aneurysm using high resolution MRI in ApoE mice." 01/27/2009 - "Furthermore, abdominal aortic aneurysms in Apoe(-/-)/Cxcl10(-/-) mice were enriched for non-T-helper type 1-related signals, including transforming growth factor-beta1. " 11/01/2003 - "Finally, Ang II-induced abdominal aortic aneurysm formation in ApoE-/-OPN-/- mice was reduced and associated with decreased MMP-2 and MMP-9 activity. " 07/15/2003 - "Near-infrared spectrometry of abdominal aortic aneurysm in the ApoE-/- mouse." 06/01/2000 - "Unexpectedly, pronounced abdominal aortic aneurysms were present in apoE(-/-) mice infused with Ang II. Sequential sectioning of aneurysmal abdominal aorta revealed two major characteristics: an intact artery that is surrounded by a large remodeled adventitia, and a medial break with pronounced dilation and more modestly remodeled adventitial tissue. "

Therapies and Procedures

1.	Transplants (Transplant) 09/01/2014 - "Effective treatment for patients with an abdominal aortic aneurysm (AAA) began more than 50 years ago through the development of prosthetic grafts, which were used to replace aneurysmal segments of diseased arteries. " 05/01/1996 - "Transfemoral placement of an endovascular graft is a viable and effective treatment of abdominal aortic aneurysms in the short term. " 07/01/2004 - "An audit was established in November 1999 by the Australian Government Department of Health and Ageing to determine the mid- to long-term safety and efficacy of endoluminal graft repair (ELG) of abdominal aortic aneurysm (AAA). " 02/01/2003 - "The purpose of this study was to evaluate the safety and efficacy of a novel endovascular graft for elective treatment of infrarenal abdominal aortic aneurysm. " 06/01/2006 - "Endoluminal grafts for abdominal aortic aneurysm repair will be the gold standard."
2.	Stents 05/01/2010 - "Fenestrated stent grafting for short-necked and juxtarenal abdominal aortic aneurysm appears safe and effective on the longer term. " 09/01/2009 - "Two patients with abdominal aortic aneurysm undergoing fenestrated stent grafting were selected for inclusion in the study. " 12/01/2001 - "The aim of this study is to conduct a quantitative analysis of cone-beam CT (CBCT) images using a phantom, and then to evaluate the clinical usefulness of CBCT in the assessment of abdominal aortic aneurysms (AAA) before and after stent-grafting, both qualitatively as well as quantitatively. " 08/01/2001 - "A rational application of the results of these animal experimental studies in clinical practice could markedly improve the long-term results of endoluminal stent grafting of abdominal aortic aneurysms." 01/01/2001 - "The early results of using endovascular covered stents for the exclusion of thoracic and infrarenal abdominal aortic aneurysms have been promising and are being investigated in multiple ongoing trials. "
3.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 09/01/2003 - "This experience suggests that combined coronary artery bypass grafting and abdominal aortic aneurysm repair is both safe and effective." 11/01/2013 - "This cardioprotective mechanism is now being translated into clinical practice, with positive results in several clinical trials in coronary artery bypass surgery, surgical repair of abdominal aortic aneurysms, valve replacement surgery and percutaneous coronary intervention. " 08/01/2014 - "We reviewed the literature for studies investigating the outcomes of combined 1-stage coronary artery bypass grafting (CABG) and abdominal aortic aneurysm (AAA) open repair (OR) procedures. " 03/01/1999 - "The purpose of this study was to examine the relationship between hospital volume and in-hospital deaths in 3 cardiovascular procedures: coronary artery bypass grafting, elective repair of abdominal aortic aneurysms, and repair of congenital cardiac defects. " 01/01/2016 - "The traditional standard of care is to conduct coronary artery bypass grafting (CABG) followed by abdominal aortic aneurysm (AAA) repair 2-6 months later, but there is significant risk with staging these 2 major surgeries. "
4.	Carotid Endarterectomy 05/01/2015 - "UK-based studies assessing cost-effectiveness or cost-utility of superficial venous interventions, abdominal aortic aneurysm (AAA) repair, and carotid endarterectomy (CEA) were included. " 06/01/2014 - "We studied all patients (n = 14,489) undergoing elective carotid endarterectomy (n = 6978), carotid stenting (n = 524), and suprainguinal (n = 763) and infrainguinal bypass (n = 3053), as well as patients with known coronary risk factors undergoing open (n = 1044) and endovascular (n = 2127) abdominal aortic aneurysm repair from 2005 to 2012 in the Vascular Study Group of New England. " 05/01/2013 - "The Vascular Study Group of New England registry was used to analyze smoking status preoperatively and at 1 year after carotid endarterectomy, carotid artery stenting, lower extremity bypass, and open and endovascular abdominal aortic aneurysm repair between 2003 and 2009. " 10/15/2011 - "One hundred ninety-eight consecutive patients who underwent major vascular surgery (58.6% infrainguinal aortic reconstruction, 23.7% abdominal aortic aneurysm surgery, 17.7% carotid endarterectomy) were included in this study. " 05/01/2004 - "All patients undergoing carotid endarterectomy (CEA) and elective abdominal aortic aneurysm repair (AAA) during the first year of SACU were included in the present study. "
5.	Kidney Transplantation 01/01/1999 - "Clinical study: (retrospective analysis): a) radiological study, 104 renal venograms; b) live related renal transplantation, 148 donor left kidneys; c) abdominal aortic aneurysm surgery, 525 patients. " 12/01/2008 - "Although the circumaortic renal collar is usually asymptomatic, the knowledge of this variation is useful, mainly before abdominal aortic aneurysm surgery and renal transplantation. " 06/01/2007 - "Renal transplantation after endovascular repair of abdominal aortic aneurysm." 11/01/2004 - "Renal transplantation in patients with abdominal aortic aneurysm--a new surgical approach." 01/01/2003 - "Endovascular repair of abdominal aortic aneurysm in renal transplantation."