Ruptured Aneurysm

The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger of a ruptured aneurysm is the large amount of blood spilling into the surrounding tissues and cavities, causing HEMORRHAGIC SHOCK.

Also Known As:

Networked: 498 relevant articles (22 outcomes, 29 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Aneurysm (Aneurysms)
2.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
3.	Intracranial Vasospasm
4.	Hemorrhage
5.	Intracranial Aneurysm (Cerebral Aneurysm)

Experts

1.	Hong, Bo: 6 articles (06/2015 - 05/2012)
2.	Xu, Yi: 5 articles (06/2015 - 05/2012)
3.	Hashimoto, Tomoki: 5 articles (06/2015 - 07/2012)
4.	Nagahiro, Shinji: 5 articles (06/2015 - 10/2004)
5.	Liu, Jian-Min: 5 articles (08/2014 - 05/2012)
6.	Huang, Qing-Hai: 5 articles (08/2014 - 05/2012)
7.	Lanzino, G: 4 articles (11/2015 - 09/2000)
8.	Tada, Yoshiteru: 4 articles (06/2015 - 07/2012)
9.	Wada, Kosuke: 4 articles (06/2015 - 01/2014)
10.	Kitazato, Keiko T: 4 articles (06/2015 - 07/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ruptured Aneurysm:

1.	Nimodipine (Modus)FDA LinkGeneric 06/01/1989 - "The efficacy of intravenous Nimodipine (used at the rate of 2 mg.h-1) was investigated in the treatment of delayed ischemic deterioration or angiographic vasospasm after subarachnoid haemorrhage caused by a ruptured aneurysm in a randomized, double-blind, placebo-controlled multicenter study. " 10/01/1999 - "One hundred twenty-seven patients of both sexes who had a ruptured aneurysm (verified using angiography), who presented with Hunt and Hess Grades I to III on admission, who underwent an operation within the first week after SAH, and who had participated in a randomized prospective clinical trial of nimodipine medication were enrolled in the study. " 02/01/2008 - "In this small series, extended intra-arterial infusion of nimodipine up to the end of the embolization procedure was effective and safe in patients with a ruptured aneurysm and associated vasospasm. " 08/01/1988 - "The therapeutic efficacy of intravenous nimodipine to treat the syndrome of delayed ischemic deterioration or vasospasm after subarachnoid hemorrhage caused by a ruptured aneurysm was investigated in a randomized, double-blind, placebo-controlled multicenter study. " 06/01/1989 - "The results of this study demonstrate the efficacy of intravenous Nimodipine in the treatment of consequences of cerebral vasospasm after a subarachnoid haemorrhage caused by a ruptured aneurysm."
2.	Serum AlbuminIBA 06/01/2007 - "Patients with a ruptured aneurysm had a significantly greater level of CRP, higher WBC, and lower serum albumin than those with an asymptomatic intact aneurysm. " 01/01/1982 - "Ten patients who developed neurological deficits associated with angiographically proven cerebral vasospasm caused by ruptured aneurysm were treated with hyperdynamic therapy induced by administration of a large amount of human serum albumin. "
3.	Propofol (Diprivan)FDA LinkGeneric 10/01/2000 - "In multivariate analysis of patients with ruptured aneurysms, younger age, better clinical grade, lower maximum systolic intraoperative blood pressure, shorter duration of surgery, and use of propofol were independently associated with better outcome. " 10/01/2000 - "Multivariate analysis of intraoperative factors affecting outcome in patients undergoing craniotomy for ruptured aneurysms shows that decreased intraoperative blood pressure and use of propofol are associated with improved outcome. " 10/01/2000 - "In univariate analysis of patients with ruptured aneurysms, younger age, better clinical grade, lower Fisher grade, lower intraoperative blood pressure (maximum systolic and mean blood pressure), smaller decrease in intraoperative compared to preoperative systolic blood pressure, shorter duration of surgery, and use of propofol, pancuronium, or N(2)O were associated with significantly better outcome. "
4.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 06/01/2006 - "We examined prospectively the efficacy of arachnoid plasty using fibrin glue membrane during surgery of ruptured aneurysms in the elderly patients for preventing complications. " 06/01/2006 - "Effect of arachnoid plasty using fibrin glue membrane after clipping of ruptured aneurysm on the occurrence of complications and outcome in the elderly patients."
5.	Pancuronium (Pavulon)FDA LinkGeneric 10/01/2000 - "In univariate analysis of patients with ruptured aneurysms, younger age, better clinical grade, lower Fisher grade, lower intraoperative blood pressure (maximum systolic and mean blood pressure), smaller decrease in intraoperative compared to preoperative systolic blood pressure, shorter duration of surgery, and use of propofol, pancuronium, or N(2)O were associated with significantly better outcome. "
6.	Dantrolene (Dantrium)FDA LinkGeneric 10/01/2012 - "Intra-arterial dantrolene induced a sustained improvement in cerebral vasospasm secondary to ruptured aneurysm. "
7.	recombinant FVIIa (rFVIIa)IBA 06/01/2013 - "Approximately 73% (n = 56) of them had ruptured aneurysms and about 50% (n = 35/70 with known data) responded positively to rFVIIa. "
8.	eptifibatide (Integrilin)FDA Link 02/01/2015 - "Eptifibatide was effective in lowering the intraoperative thromboembolic complication rate in ruptured aneurysms treated with coil embolization and did not increase the hemorrhagic risk."
9.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 01/01/1993 - "Though suboptimal in a general sense, incomplete vascular studies, if four vessel angiography is not obtainable without delay or risk, should not delay earliest possible clipping of ruptured aneurysms to avoid the devastating effects of recurrent bleeds." 09/01/1987 - "In 9 (22.0%) of 41 patients whose cause of SAH was not determined by the first four-vessel study (cerebral panangiography), ruptured aneurysms were found by repeated four-vessel study. " 05/01/2014 - "Ours is the first case in which a ruptured aneurysm of this vessel was treated surgically with concurrent vascular reconstruction. " 11/01/2013 - "Overriding role of parent over daughter vessel dimension in size ratio detection performance of bifurcation aneurysms ruptured status." 03/01/2013 - "The ruptured aneurysms demonstrated thick vessel wall enhancement in all cases. "
10.	Nicardipine (Dagan)FDA LinkGeneric 03/01/2013 - "Medline, EMBASE, and PubMed databases were searched for the controlled trials evaluating nicardipine for treating SAH after a ruptured aneurysm, without language restrictions. " 04/01/1993 - "This hypothesis was tested in an arm of a randomized double-blind placebo-controlled trial of high-dose intravenous nicardipine in patients with recently ruptured aneurysms. "

Therapies and Procedures

1.	Endovascular Procedures 01/01/2007 - "Since then, a less invasive endovascular technique has been found effective in a trial of ruptured aneurysms. " 07/01/2014 - "Treatment of patients with ruptured aneurysm by neurosurgeons that perform both open surgical and endovascular techniques is safe and effective: results of a single centre in Europe." 09/01/2000 - "Although surgical clipping of the ruptured aneurysm remains the gold standard therapy, with the continuing refinement of endovascular techniques, a new, 'less invasive' option is now available, especially for patients considered poor surgical candidates." 05/01/2007 - "We reviewed the medical records, radiographical studies and endovascular procedures to evaluate the morbidity and mortality related to ruptured aneurysm coiling. " 12/01/2015 - "Endovascular techniques have gained importance in recent years in the treatment of acutely ruptured aneurysms. "
2.	Stents 01/01/2008 - "These cases suggested that stent-assisted GDC embolization is effective for prevention of rebleeding from ruptured aneurysm during long-term observation even with sufficient dose of antiplatelets therapy. " 09/01/2005 - "The purpose of this study was to evaluate the procedural risk of treating acute ruptured aneurysms with a stent-coil combination. " 08/01/2015 - "Stent-assisted coiling has been used in both unruptured and ruptured aneurysms, but the safety and efficacy still remain controversial. " 05/01/2015 - "Twelve unruptured and eight ruptured aneurysms in 20 patients were treated with crossing Y-stent-assisted coiling. " 02/01/2015 - "Between May 2007 and November 2011, a total of 35 micro-intracranial wide-necked ruptured aneurysms were occluded with Enterprise stent-assisted coils. "
3.	Surgical Instruments (Clip) 02/01/2015 - "Propensity score matching was used to adjust the differences in age, sex, modified Fisher grade, World Federation of Neurosurgical Societies (WFNS) clinical grade at admission, size and location of a ruptured aneurysm, treatment modality (clip placement vs coil embolization), and time interval from SAH to admission between the two time periods. " 01/01/2015 - "These cases should be informative as they show extremely long-term course of a clip applied for a ruptured aneurysm." 02/01/2013 - "For ruptured aneurysms, there was a statistically significant difference in clipping and coiling with respect to age and treatment modality (clip 48.8 years, coil 57.6 years). " 02/01/2010 - "In the last four years, 9 cases of ruptured aneurysms treated by the clip-wrap techniques were identified in the Division of Neurological Surgery, University of São Paulo, School of Medicine. " 01/01/2004 - "Twenty four ruptured aneurysms underwent the clip occlusion (100%). "
4.	Transplants (Transplant) 01/01/2014 - "In addition, symptomatic and ruptured aneurysms, as well as infected aortic grafts can be operated on with optimal results, without a notable increase in mortality." 01/01/2012 - "An 85-year-old man, who had a ruptured aneurysm of the deep femoral artery, underwent aneurysmectomy and distal reconstruction with a contralateral autologous vein graft. " 03/01/2009 - "Mortality for conversion for infected grafts and ruptured aneurysms remains high. " 01/01/2009 - "Regarding the reported case, excision of the ruptured aneurysm and restoration of vascular continuity with a vein graft ensured complete survival of the flap. " 05/01/2006 - "Statistical analysis showed that advanced age (over 70 years), the need for more extensive reconstructive surgery along with the implantation of the bifurcated graft, as well as the presence of ruptured aneurysms, significantly increased the mortality of the patients. "
5.	Craniotomy 01/01/2011 - "Until recently, this exclusively involved the surgical clipping of the ruptured aneurysm via a craniotomy. " 02/01/2010 - "The most common cause of the original craniotomy (54% of patients) was an oncological aetiology, followed by ruptured aneurysms or haemorrhage in 31% of the patients. " 04/01/2009 - "Eleven craniotomies for neck clipping were performed for 11 ruptured aneurysms. " 09/01/2006 - "Between April 2002 and March 2004, we prospectively investigated mechanisms of spontaneous hemostasis in ruptured aneurysms by macroscopic examination when performing craniotomy and clipping surgeries. " 06/01/2006 - "The eligible patient fulfilled the following conditions; (1) ruptured aneurysm located in the anterior part of the circle of Willis, (2) surgically clipped followed by craniotomy under microscope, (3) early surgery within 72 hours, (4) classified to WFNS grade I or II. The medical records were retrospectively reviewed in 119 patients (63 of grade I and 56 of grade II). "