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IGF Type 2 Receptor (Insulin-Like-Growth-Factor II Receptor)

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A receptor that is specific for IGF-II and mannose-6-phosphate. The receptor is a 250-kDa single chain polypeptide which is unrelated in structure to the type 1 IGF receptor (RECEPTOR, IGF TYPE 1) and does not have a tyrosine kinase domain.

Also Known As:

Insulin-Like-Growth-Factor II Receptor; Receptor, IGF Type 2; IGF-2 Receptor; Mannose-6-Phosphate Receptor; Receptors, IGF-2; Receptors, Insulin-Like Growth Factor II; IGF 2 Receptor; IGF II Receptor; IGF-2 Receptors; Insulin Like Growth Factor II Receptor; Mannose 6 Phosphate Receptor; Receptor, IGF II; Receptor, IGF-2; Receptor, Insulin Like Growth Factor II; Receptor, Insulin Like Growth Factor Type 2; Receptor, Insulin-Like-Growth-Factor II; Receptor, Mannose 6 Phosphate; Receptors, IGF 2; Receptors, Insulin Like Growth Factor II; IGF-II Receptor; Receptor, IGF-II; Receptor, Insulin-Like Growth Factor II; Receptor, Insulin-Like Growth Factor Type 2; Receptor, Mannose-6-Phosphate

Networked: 147 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753
      - Peptide Receptors: 579
        Growth Factor Receptors: 766
        Somatomedin Receptors: 289
        IGF Type 2 Receptor: 147
        rat MPR300 protein

Experts

1.	Koeberl, Dwight D: 4 articles (05/2014 - 11/2010)
2.	Scott, Carolyn D: 3 articles (12/2013 - 11/2002)
3.	Li, Songtao: 3 articles (01/2013 - 11/2010)
4.	Sun, Baodong: 3 articles (01/2013 - 11/2010)
5.	Zavras, Athanasios I: 3 articles (06/2012 - 01/2003)
6.	Huang, Chih-Yang: 3 articles (06/2009 - 08/2006)
7.	Chu, Chun-Hsien: 3 articles (06/2009 - 08/2006)
8.	Kuo, Wei-Wen: 3 articles (06/2009 - 08/2006)
9.	Jeanjean, Audrey: 2 articles (05/2015 - 05/2006)
10.	Morère, Alain: 2 articles (05/2015 - 05/2006)

Related Diseases

1.	Glycogen Storage Disease Type II (Pompe's Disease) 11/01/2010 - "Antibody formation and mannose-6-phosphate receptor expression impact the efficacy of muscle-specific transgene expression in murine Pompe disease." 06/01/2011 - "Enhanced efficacy of enzyme replacement therapy in Pompe disease through mannose-6-phosphate receptor expression in skeletal muscle." 05/01/2014 - "Effective dosages for enzyme replacement therapy (ERT) in Pompe disease are much higher than for other lysosomal storage disorders, which has been attributed to low cation-independent mannose-6-phosphate receptor (CI-MPR) in skeletal muscle. " 01/01/2008 - "Abnormal mannose-6-phosphate receptor trafficking impairs recombinant alpha-glucosidase uptake in Pompe disease fibroblasts." 01/01/2013 - "Pompe disease has resisted enzyme replacement therapy with acid α-glucosidase (GAA), which has been attributed to inefficient cation-independent mannose-6-phosphate receptor (CI-MPR) mediated uptake. "
2.	Neoplasms (Cancer) 11/01/2012 - "This effect was mediated by transient but dramatic upregulation of the mannose-6-phosphate receptor (MPR) on the tumor cell surface. " 06/01/2012 - "Insulin-like growth factor II receptor (IGF2R) degrades mitogen and hence is associated with tumor suppressor function. " 02/08/2008 - "Normal function of insulin-like growth factor II receptor (IGF2R) gene has been associated with negative control of tumor growth in vivo and in vitro. " 05/01/2004 - "The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal?" 04/01/2001 - "The insulin-like growth factor-II receptor (IGF-IIR) is frequently mutated or deleted in some malignant human tumors, suggesting that the IGF-IIR is a tumor suppressor. "
3.	Carcinoma (Carcinomatosis) 01/01/1994 - "Analysis of the IGF-II receptor gene copy number in breast carcinoma." 01/01/1994 - "In order to determine whether the Man-6-P/IGF-II receptor gene copy number is altered in breast cancer we analysed specimens of invasive breast carcinoma from 51 patients by Southern blotting. " 03/01/2003 - "Mannose-6-phosphate/insulin-like growth factor-II receptor expression levels during the progression from normal human mammary tissue to invasive breast carcinomas." 02/01/2003 - "Oxidative damage was investigated on the two genes in gastric mucosal tissue infected with Helicobacter pylori, which were genes of glyceraldehydes-3-phosphate dehydrogenase (GAPDH), a house-keeping gene, and gene of insulin-like growth factor II receptor (IGFIIR), a gene known to be mutated frequently in gastric carcinoma. " 02/15/2000 - "Stable amino-acid sequence of the mannose-6-phosphate/insulin-like growth-factor-II receptor in ovarian carcinomas with loss of heterozygosity and in breast-cancer cell lines."
4.	Hepatocellular Carcinoma (Hepatoma) 06/01/2003 - "It was reported that 60-70% of hepatitis B virus (HBV)-negative hepatocellular carcinoma (HCC) had loss of heterozygosity (LOH) at the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) locus and this gene was mutated in 55% of these patients with LOH. " 06/01/2003 - "Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma." 05/01/2002 - "Mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) tumor suppressor- gene mutation is an early event in human hepatocellular carcinoma (HCC) formation in the United States, but its role in hepatocarcinogenesis in Japan is unclear. " 11/01/1987 - "These results indicate that the IGF-II receptor mediates a particular biological response--stimulation of glycogen synthesis in hepatoma cells. " 08/01/1995 - "Transforming growth factor-beta receptors and mannose 6-phosphate/insulin-like growth factor-II receptor expression in human hepatocellular carcinoma."
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2001 - "Microsatellite Analysis of the Insulin-Like Growth Factor II Receptor in Colorectal Carcinomas." 07/15/1999 - "Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells." 01/01/2015 - "The aim of this study was to investigate the expression of IGF-2 after 5-aminolevulinic acid (5-ALA)-mediated-PDT in SW620 human colorectal cancer cells with evaluation of cell proliferation and apoptosis and to determine the effects of PDT on the IGF-2 receptor (IGF-2R), IGF-2 binding protein-1 (IGF-2BP-1) and the proapoptotic protein, BAX. " 10/01/2000 - "Eighty-six regions from 16 MSI-positive sporadic colorectal carcinomas were examined for mutations in repeat nucleotide sequences of the tumour suppressor genes transforming growth factor beta type II receptor (TGFBRII), insulin-like growth factor II receptor (IGFIIR), and BAX, and the mismatch repair genes MSH3 and MSH6. " 04/01/2000 - "About 15% of sporadic colorectal carcinomas arise via a mechanism associated with microsatellite instability (MSI) and mutations in transforming growth factor beta receptor II (TGFbetaRII), insulin-like growth factor II receptor (IGFIIR) and BAX, whilst the remaining 85% are associated with aneuploidy and gross chromosomal rearrangements. "

Related Drugs and Biologics

1.	Insulin-Like Growth Factor II (Somatomedin A)
2.	Insulin-Like Growth Factor I (IGF-1)
3.	Insulin (Novolin)
4.	Antibodies
5.	Mannose (D-Mannose)
6.	Transforming Growth Factor beta (TGF-beta)
7.	IGF Type 1 Receptor (IGF 1 Receptor)
8.	Transforming Growth Factor beta1 (TGF beta 1)
9.	Insulin Receptor
10.	RNA (Ribonucleic Acid)

Related Therapies and Procedures

1.	Enzyme Replacement Therapy
2.	Drug Therapy (Chemotherapy)
3.	Ligation
4.	Heart Transplantation (Grafting, Heart)