Pityriasis Rosea

A mild exanthematous inflammation of unknown etiology. It is characterized by the presence of salmon-colored maculopapular lesions. The most striking feature is the arrangement of the lesions such that the long axis is parallel to the lines of cleavage. The eruptions are usually generalized, affecting chiefly the trunk, and the course is often self-limiting.

Networked: 194 relevant articles (15 outcomes, 24 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris)
2.	Bullous Pemphigoid (Pemphigoid)
3.	Pruritus (Itching)
4.	Pemphigus (Pemphigus Vulgaris)
5.	Pityriasis Lichenoides (Pityriasis Lichenoides et Varioliformis Acuta)

Experts

1.	Drago, Francesco: 7 articles (12/2022 - 06/2005)
2.	Ciccarese, Giulia: 4 articles (12/2022 - 01/2015)
3.	Parodi, Aurora: 4 articles (12/2022 - 01/2014)
4.	Singal, Archana: 3 articles (01/2015 - 01/2014)
5.	Verma, Prashant: 3 articles (01/2015 - 01/2014)
6.	Thappa, Devinder Mohan: 3 articles (09/2011 - 04/2004)
7.	Borlu, Murat: 2 articles (09/2022 - 11/2020)
8.	Gökçek, Gözde Emel: 2 articles (09/2022 - 01/2022)
9.	Cardenas-de la Garza, J A: 2 articles (01/2022 - 01/2021)
10.	Cuellar-Barboza, A: 2 articles (01/2022 - 01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pityriasis Rosea:

1.	Acyclovir (Aciclovir)FDA LinkGeneric 01/01/2006 - "Acyclovir may be effective in the treatment of pityriasis rosea, especially in patients treated in the first week from onset, when replicative viral activity of HHV is probably very high." 05/01/2014 - "The study showed that high dose acyclovir is effective in the treatment of pityriasis rosea." 09/01/2016 - "Acyclovir is considered to be an effective treatment for pityriasis rosea but randomized, blinded, placebo-controlled trials have not been performed. " 09/01/2016 - "Acyclovir is not an effective treatment for pityriasis rosea." 09/01/2016 - "To test the efficacy of acyclovir in pityriasis rosea in a randomized, triple-blind, placebo-controlled trial. "
2.	Erythromycin (Erycette)FDA LinkGeneric 01/01/2008 - "Erythromycin is reported to be effective in the treatment of pityriasis rosea. " 02/01/2000 - "Oral erythromycin was effective in treating patients with pityriasis rosea." 02/01/2000 - "The purpose of the study was to evaluate the efficacy of erythromycin in patients with pityriasis rosea. " 02/01/2000 - "The study stemmed from an incidental observation of improvement in 2 patients with pityriasis rosea while receiving erythromycin. " 03/01/2002 - "A double-blind placebo-controlled trial reported the benefit of erythromycin in treating pityriasis rosea (PR), a postulated mechanism being the eradication of bacteria susceptible to erythromycin. "
3.	Azithromycin (Zithromax)FDA LinkGeneric 01/01/2015 - "Author's Response--The efficacy of azithromycin in pityriasis rosea: a randomized, double-blind, placebo-controlled trial." 01/01/2014 - "The efficacy of azithromycin in pityriasis rosea: a randomized, double-blind, placebo-controlled trial." 01/01/2014 - "Seventy patients of pityriasis rosea were given either azithromycin (n=35) or placebo (n=35) and were followed-up at 2, 4 and 6 weeks. " 05/01/2006 - "Azithromycin does not cure pityriasis rosea." 01/01/2014 - "A randomized double-blind placebo-controlled trial was conducted to evaluate the effect of azithromycin on the clinical course of pityriasis rosea. "
4.	MacrolidesIBA 01/01/2014 - "Macrolides are prescribed in the treatment of pityriasis rosea despite conflicting results of the limited number of studies evaluating their role in its treatment. " 01/01/2012 - "These observations provided the rationale for many studies performed to assess the usefulness of macrolides in other inflammatory diseases including skin and hair disorders, such as rosacea, psoriasis, pityriasis rosea, alopecia areata, bullous pemphigoid, and pityriasis lichenoides. " 01/01/2015 - "The efficacy of macrolides and acyclovir in pityriasis rosea." 01/01/2014 - "Azithromycin is not effective in pityriasis rosea and the use of macrolides for this disease should not be encouraged in clinical practice."
5.	Anti-Bacterial Agents (Antibiotics)IBA 03/01/2010 - "However, due to minimal data, antibiotics may still have a role in pityriasis rosea." 07/01/2002 - "Based on existing clinical trials with a higher number of cases the following antibiotics have been shown to be effective: erythromycin in bullous pemphigoid and pityriasis rosea as well as tetracyclines in pemphigus vulgaris, bullous pemphigoid and pustulosis palmaris et plantaris. "
6.	TetracyclinesIBA 07/01/2002 - "Based on existing clinical trials with a higher number of cases the following antibiotics have been shown to be effective: erythromycin in bullous pemphigoid and pityriasis rosea as well as tetracyclines in pemphigus vulgaris, bullous pemphigoid and pustulosis palmaris et plantaris. "
7.	Clarithromycin (Biaxin)FDA LinkGeneric 11/01/2014 - "To determine the efficacy of clarithromycin in the treatment of Pityriasis Rosea (PR). " 11/01/2014 - "Efficacy of clarithromycin in pityriasis rosea." 11/01/2014 - "Clarithromycin is not effective in treatment of pityriasis rosea." 03/01/2012 - "A diagnosis of pityriasis rosea was made and the patient was started on clarithromycin 500 mg once a day for 7 days, along with antihistamines and emollients. "
8.	AntibodiesIBA 01/01/1997 - "Serum antibodies to parvovirus B19 in patients with pityriasis rosea." 08/01/1995 - "Legionella micdadei antibodies were detected in 12 (33.3%) Pityriasis rosea cases and in one (5.2%) control. " 08/01/1995 - "We have thus tested the sera of 36 patients ill with Pityriasis rosea and 19 controls for Legionella pneumophila serogroup 1-6 and Legionella micdadei antibodies. " 08/01/1995 - "Pityriasis rosea Gibert: detection of Legionella micdadei antibodies in patients." 01/01/1976 - "The significance of these findings is discussed with respect to anticytoplasmic antibodies in the sera of patients with pityriasis rosea."
9.	COVID-19 VaccinesIBA 01/01/2023 - "The association between pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccines was established, but given the scarcity of studies, there is a need to conduct different clinical trials to confirm this association further and study the etiology and mechanism of the disease." 01/01/2023 - "After introducing Covid-19 vaccines, a few side effects were reported, pityriasis rosea being one of them. " 01/01/2023 - "Manifestation of pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccine: A systematic review." 12/01/2022 - "Pityriasis rosea and pityriasis rosea-like eruptions after COVID-19 vaccines." 01/01/2022 - "We present two cases of COVID-19 vaccine-induced pityriasis rosea. "
10.	BismuthIBA 03/01/2006 - "Pityriasis rosea-like eruption due to bismuth." 03/01/2006 - "We report a case of bismuth-induced pityriasis rosea-like drug eruption. " 07/01/1949 - "Pityriasis rosea-like drug eruptions due to bismuth." 12/27/1950 - "[Trial treatment of Gibert's pityriasis rosea with bismuth and penicillin]."

Therapies and Procedures

1.	Phototherapy (Light Therapy) 12/01/1995 - "Seventeen patients with extensive pityriasis rosea were treated with unilateral UVB phototherapy in a bilateral comparison study. " 12/01/1995 - "UVB phototherapy for pityriasis rosea: a bilateral comparison study." 05/01/1983 - "Twenty patients with symptomatic and extensive pityriasis rosea were treated with unilateral UV-B phototherapy in a bilateral comparison study. " 09/01/2015 - "Narrowband UVB phototherapy in pityriasis rosea." 08/01/2009 - "Low-dose Ultraviolet A1 Phototherapy for Treating Pityriasis Rosea."
2.	Therapeutics 03/01/1982 - "Cutaneous reactions, including (rarely) a pityriasis rosea-like eruption, are frequently associated with this therapy. " 01/01/2022 - "Can COVID-19 cause atypical forms of pityriasis rosea refractory to conventional therapies?" 06/01/1996 - "A pityriasis rosea-like eruption secondary to bacillus Calmette-Guérin therapy for bladder cancer." 01/01/1985 - "Prodromal symptoms, course and response to therapy were compatible with pityriasis rosea. " 06/01/1958 - "Calciferol therapy in dermatitis herpetiformis and pityriasis rosea."
3.	Oral Diagnosis (Oral Examination) 10/01/1992 - "A complete oral examination in a patient presenting with a papulosquamous eruption may be helpful in ascertaining the diagnosis of pityriasis rosea." 10/01/1992 - "Fifty-one consecutive patients with clinical findings and history consistent with pityriasis rosea underwent a complete oral examination to search for any concomitant oral lesions. "
4.	Aftercare (After-Treatment) 08/01/2009 - "The purpose of the present study was to assess the clinical efficacy of UVA1 (340~400 nm) phototherapy for treating pityriasis rosea and to assess the course of the disease after treatment. " 12/01/1995 - "Our purpose was to evaluate the clinical efficacy of UVB phototherapy in pityriasis rosea and the course of the disease after treatment. " 01/01/1985 - "A 4-year-old female patient who developed a skin eruption similar to pityriasis rosea after treatment with ketotifen (Zaditen) is presented. "
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 08/01/1994 - "Pityriasis rosea-like eruption after bone marrow transplantation."