Pityriasis Lichenoides (Pityriasis Lichenoides et Varioliformis Acuta)

A subgroup of PARAPSORIASIS itself divided into acute and chronic forms. The acute form is characterized by the abrupt onset of a generalized, reddish-brown, maculopapular eruption. Lesions may be vesicular, hemorrhagic, crusted, or necrotic. Histologically the disease is characterized by epidermal necrolysis. The chronic form shows milder skin changes with necrosis.

Also Known As:

Networked: 110 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pityriasis Lichenoides (Pityriasis Lichenoides et Varioliformis Acuta)
2.	Psoriasis (Pustulosis Palmaris et Plantaris)
3.	Skin Diseases
4.	Lymphomatoid Papulosis
5.	Dermatitis

Experts

1.	Ersoy-Evans, Sibel: 3 articles (11/2012 - 11/2008)
2.	Tsorova, Christina: 2 articles (02/2010 - 01/2008)
3.	Patsatsi, Aikaterini: 2 articles (02/2010 - 01/2008)
4.	Sahin, Sedef: 2 articles (01/2009 - 11/2008)
5.	Kölemen, Fikret: 2 articles (01/2009 - 11/2008)
6.	Magro, Cynthia M: 2 articles (11/2008 - 04/2008)
7.	Piérard, G E: 2 articles (10/2008 - 01/2000)
8.	Morrison, Carl: 2 articles (04/2008 - 12/2004)
9.	Yang, Chao-Chun: 2 articles (10/2006 - 09/2003)
10.	Lee, Julia Yu-Yun: 2 articles (10/2006 - 09/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pityriasis Lichenoides:

1.	Erythromycin (Erycette)FDA LinkGeneric 11/01/2012 - "Pityriasis lichenoides (PL) is not uncommon in childhood, but current knowledge about the efficacy of oral erythromycin therapy for its treatment in children is limited. " 07/01/1986 - "A trial of erythromycin as described herein should be considered in children with pityriasis lichenoides before other, possibly more toxic, measures are instituted." 11/01/2012 - "Childhood pityriasis lichenoides and oral erythromycin." 07/01/1986 - "Fifteen of twenty-two children with pityriasis lichenoides were treated with oral erythromycin. " 07/01/1986 - "Pityriasis lichenoides in children: therapeutic response to erythromycin."
2.	AntigensIBA 03/01/2014 - "The etiologic agents for pityriasis lichenoides et varioliformis acuta (PLEVA) are largely unknown, although it has been suggested that foreign antigens such as infectious agents are the pathogenic mechanism. " 10/01/2001 - "Expression of cutaneous lymphocyte-associated antigen and TIA-1 by lymphocytes in pityriasis lichenoides et varioliformis acuta and lymphomatoid papulosis: immunohistochemical study." 10/01/1991 - "Ki-1 Ag positive, large, atypical, lymphoid cells were always seen in lymphomatoid papulosis; none of lymphoid cells of pityriasis lichenoides et varioliformis acuta demonstrated this antigen. " 03/01/1987 - "Pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica both exhibited a dermal and epidermal infiltrate of CD4+ and CD8+ T cells expressing activation antigens. "
3.	MacrolidesIBA 01/01/2012 - "These observations provided the rationale for many studies performed to assess the usefulness of macrolides in other inflammatory diseases including skin and hair disorders, such as rosacea, psoriasis, pityriasis rosea, alopecia areata, bullous pemphigoid, and pityriasis lichenoides. "
4.	Aromatic Polycyclic Hydrocarbons (Polycyclic Aromatic Hydrocarbons)IBA 04/01/1997 - "In order to study the dermal uptake, time course, and urinary excretion of polycyclic aromatic hydrocarbons, the concentration of 1-hydroxypyrene in urine was determined by means of high performance liquid chromatography with fluorescence detection before, during, and after the topical treatment with coal tar in 19 patients suffering from prurigo simplex subacuta, microbial eczema, atopic dermatitis, eczematization after scabies, exanthematous lichen ruber, pityriasis lichenoides and cutaneous sarcoidosis. "
5.	Immunoglobulin M (IgM)IBA 11/01/1978 - "In a study of 27 patients with pityriasis lichenoides IgM and C3 have been observed on direct immunofluorescence of fresh lesions. "
6.	Coal Tar (Estar)IBA 04/01/1997 - "In order to study the dermal uptake, time course, and urinary excretion of polycyclic aromatic hydrocarbons, the concentration of 1-hydroxypyrene in urine was determined by means of high performance liquid chromatography with fluorescence detection before, during, and after the topical treatment with coal tar in 19 patients suffering from prurigo simplex subacuta, microbial eczema, atopic dermatitis, eczematization after scabies, exanthematous lichen ruber, pityriasis lichenoides and cutaneous sarcoidosis. "
7.	1-hydroxypyreneIBA 04/01/1997 - "In order to study the dermal uptake, time course, and urinary excretion of polycyclic aromatic hydrocarbons, the concentration of 1-hydroxypyrene in urine was determined by means of high performance liquid chromatography with fluorescence detection before, during, and after the topical treatment with coal tar in 19 patients suffering from prurigo simplex subacuta, microbial eczema, atopic dermatitis, eczematization after scabies, exanthematous lichen ruber, pityriasis lichenoides and cutaneous sarcoidosis. "
8.	styrene-methylmethacrylate copolymerIBA 04/01/1997 - "In order to study the dermal uptake, time course, and urinary excretion of polycyclic aromatic hydrocarbons, the concentration of 1-hydroxypyrene in urine was determined by means of high performance liquid chromatography with fluorescence detection before, during, and after the topical treatment with coal tar in 19 patients suffering from prurigo simplex subacuta, microbial eczema, atopic dermatitis, eczematization after scabies, exanthematous lichen ruber, pityriasis lichenoides and cutaneous sarcoidosis. "
9.	Febrile Ulceronecrotic Mucha-Habermann diseaseIBA 01/01/2013 - "Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a severe variant of pityriasis lichenoides et varioliformis acuta (PLEVA). " 01/01/2008 - "We report here a case of a 20-year-old woman in whom the disease started as pityriasis lichenoides et varioliformis acuta and evolved to febrile ulceronecrotic Mucha-Habermann disease. " 03/01/2006 - "Ulceronecrotic Mucha-Habermann disease is a severe, febrile form of pityriasis lichenoides et varioliformis acuta. " 04/01/2005 - "Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) represents a fulminant and potentially lethal variant of pityriasis lichenoides. " 12/01/2004 - "Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a severe variant of pityriasis lichenoides et varioliformis acuta (PLEVA). "
10.	Methotrexate (Mexate)FDA LinkGeneric 11/01/2014 - "Steroid unresponsive case of ulcerative mucha-habermann disease (febrile ulcernecrotic mucha-habermann disease) treated with methotrexate." 02/01/2010 - "Resistant pityriasis lichenoides et varioliformis acuta in a 3-year-old boy: successful treatment with methotrexate." 02/01/1975 - "[Treatment of pityriasis lichenoides et varioliformis acuta with methotrexate]." 10/01/1972 - "Methotrexate for the treatment of Mucha-Habermann disease." 05/01/1979 - "Methotrexate treatment of pityriasis lichenoides and lymphomatoid papulosis."

Therapies and Procedures

1.	Phototherapy (Light Therapy) 06/01/2013 - "Regardless of the absence of clinical guidelines, both therapeutic options proved to be successful, ascertaining phototherapy as an effective and safe option for pityriasis lichenoides patients." 06/01/2008 - "The purpose of the present study was to assess the efficacy of NB-UVB phototherapy in the management of pityriasis lichenoides (PL). " 12/01/2013 - "Narrowband UVB phototherapy for pediatric generalized pityriasis lichenoides." 06/01/2013 - "Phototherapy for pityriasis lichenoides: our experience." 01/01/2009 - "Narrowband ultraviolet-B phototherapy in pityriasis lichenoides chronica."
2.	Tonsillectomy 07/01/2011 - "Pityriasis lichenoides et varioliformis acuta exacerbated after tonsillectomy." 09/01/1993 - "Pityriasis lichenoides chronica resolving after tonsillectomy." 12/01/1991 - "Mucha-Habermann disease resolves after tonsillectomy."
3.	PUVA Therapy 10/01/2003 - "[ PUVA therapy of severe-course pityriasis lichenoides et varioliformis acuta]." 01/01/1979 - "2 patients with long-standing and wide-spread pityriasis lichenoides chronica were treated with orally administered 8-methyoxypsoralen and UVA irradiation (PUVA therapy). " 01/01/1979 - "[Pityriasis lichenoides chronica--a new indication for PUVA therapy? " 10/01/1978 - "Experimental PUVA therapy in five different skin diseases showed excellent results in lichen planus and pityriasis lichenoides et varioliformis. "
4.	Photochemotherapy (Photodynamic Therapy) 01/01/2008 - "Pityriasis lichenoides chronica: good response to photodynamic therapy." 02/01/2004 - "In our opinion, photochemotherapy, which has never been used in pityriasis lichenoides, is effective. " 02/01/2004 - "We report the first 3 cases of pityriasis lichenoides treated by photochemotherapy. " 02/01/2004 - "Various types of therapy have been proposed for pityriasis lichenoides, to our knockledge, photochemotherapy has never been used. " 02/01/2004 - "[Photochemotherapy for pityriasis lichenoides: 3 cases]."
5.	Transplants (Transplant) 07/01/2013 - "The aim was to present Mucha-Habermann disease that occurred in an old man who had a heart transplant. " 07/01/2013 - "[Mucha-Habermann disease and orthotopic heart transplant. "