Hidradenitis Suppurativa

A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.

Also Known As:

Networked: 1547 relevant articles (152 outcomes, 144 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris)
2.	Acne Vulgaris
3.	Pyoderma Gangrenosum
4.	Atopic Dermatitis (Atopic Eczema)
5.	Pityriasis Rubra Pilaris

Experts

1.	Jemec, Gregor B E: 31 articles (10/2022 - 06/2004)
2.	Fabbrocini, Gabriella: 23 articles (10/2022 - 01/2017)
3.	Frew, John W: 23 articles (10/2022 - 01/2018)
4.	Prens, Errol P: 20 articles (10/2022 - 01/2009)
5.	Szepietowski, Jacek C: 19 articles (01/2022 - 09/2009)
6.	Marasca, Claudio: 17 articles (10/2022 - 01/2017)
7.	Hamzavi, Iltefat H: 17 articles (06/2022 - 04/2010)
8.	Molina-Leyva, Alejandro: 17 articles (02/2022 - 10/2018)
9.	Zouboulis, Christos C: 17 articles (01/2022 - 01/2010)
10.	Alavi, Afsaneh: 15 articles (07/2022 - 01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hidradenitis Suppurativa:

1.	Adalimumab (Humira)FDA Link 10/01/2021 - "Adalimumab provides significant efficacy for patients with hidradenitis suppurativa (HS), which was demonstrated by at least 50% of patients achieving a clinical response by week 12 that was maintained through to week 168 in the PIONEER trials. " 10/01/2023 - "Combining adalimumab with surgery resulted in greater clinical effectiveness and improved quality of life after 12 months in patients with moderate to severe hidradenitis suppurativa." 07/01/2023 - "Surgical deroofing has also been shown to be an effective therapeutic option in the loss/lack of efficacy of adalimumab in patients with hidradenitis suppurativa (Hurley II-III). " 01/01/2018 - "MABp1 is a promising treatment for patients with hidradenitis suppurativa not eligible for adalimumab. " 03/01/2023 - "Potential Predictors of Cardiovascular Risk Improvement in Patients with Hidradenitis Suppurativa Treated with Adalimumab: A Pivotal Study of Factors Associated with Carotid Intima-Media Thickness Reduction."
2.	Infliximab (Remicade)FDA Link 12/01/2007 - "Infliximab appears to be an effective medical approach to the management of hidradenitis suppurativa and also to prepare the patient for "curative" surgery. " 08/16/2023 - "JAAD Game Changer: "High-dose, high-frequency infliximab: A novel treatment paradigm for hidradenitis suppurativa"." 06/01/2021 - "This cohort study found that both infliximab administration and infliximab-abda administration were associated with similar and significant improvement in disease as measured by the Hidradenitis Suppurativa Clinical Response. " 01/01/2021 - "Comment on "High-dose, high-frequency infliximab: A novel treatment paradigm for hidradenitis suppurativa"." 01/01/2021 - "Authors' reply to the comment "High-dose, high-frequency infliximab: A novel treatment paradigm for hidradenitis suppurativa"."
3.	Clindamycin (Cleocin)FDA LinkGeneric 06/01/1983 - "Topical treatment of hidradenitis suppurativa with clindamycin." 12/01/2021 - "Clindamycin Mono-Therapy of Hidradenitis Suppurativa Patients: A Single-Center Retrospective Study." 06/01/1983 - "Thirty patients with recurrent suppurative hidradenitis entered a double blind trial to evaluate the effect of topical clindamycin against placebo in hidradenitis. " 01/01/2022 - "Allergic Contact Dermatitis to Topical Clindamycin in a Patient with Hidradenitis Suppurativa." 01/01/2022 - "Response to the article by Kwak et al entitled "No increased incidence of Clostridium difficile infection among patients with hidradenitis suppurativa treated with systemic clindamycin"."
4.	Rifampin (Rifampicin)FDA LinkGeneric 01/01/2022 - "Mechanism of anti-inflammatory effects of rifampicin in an ex vivo culture system of hidradenitis suppurativa." 01/01/2019 - "Is it time to abandon rifampicin for hidradenitis suppurativa? " 01/01/2019 - "Is it time to abandon rifampicin for hidradenitis suppurativa?" 05/15/2018 - "Clinicians should be aware of the risk of Clostridium difficile infection in patients with hidradenitis suppurativa, even in those receiving rifampin." 01/01/2018 - "Response to 'Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?'"
5.	Anti-Bacterial Agents (Antibiotics)IBA 02/01/2011 - "Antibiotics have been shown to improve hidradenitis suppurativa (HS) patients but complete remission is rare using these treatments. " 10/20/2022 - "Retrospective Cohort Study on Asian Patients with Hidradenitis Suppurativa: Factors Associated with the Efficacy of Antibiotic Treatment." 01/01/2023 - "External Validation of the IHS4-55 in a European Antibiotic-Treated Hidradenitis Suppurativa Cohort." 11/01/2022 - "Antibiotics are frequently used to treat hidradenitis suppurativa (HS), but the evidence-based literature available on their use is limited. " 11/01/2022 - "Treatment options for moderate-to-severe hidradenitis suppurativa (HS) comprise antibiotics, biologics, and different surgical methods. "
6.	Etanercept (Enbrel)FDA Link 04/01/2006 - "Etanercept: effective in the management of hidradenitis suppurativa." 06/01/2010 - "Long-term efficacy of etanercept in hidradenitis suppurativa: results from an open-label phase II prospective trial." 06/01/2010 - "To evaluate the long-term efficacy of etanercept for the management of hidradenitis suppurativa. " 11/01/2008 - "Long-term efficacy of etanercept in hidradenitis suppurativa." 03/01/2008 - "To evaluate the safety and efficacy of etanercept for the management of hidradenitis suppurativa. "
7.	secukinumabIBA 01/01/2023 - "When given every 2 weeks, secukinumab was clinically effective at rapidly improving signs and symptoms of hidradenitis suppurativa with a favourable safety profile and with sustained response up to 52 weeks of treatment. " 12/01/2023 - "Recently, a new biologic medication, secukinumab, has demonstrated promising results in the treatment of hidradenitis suppurativa in its phase III clinical trials. " 12/01/2023 - "Recently, secukinumab has demonstrated promising results in the treatment of hidradenitis suppurativa in the phase III SUNSHINE and SUNRISE clinical trials. " 01/01/2023 - "We aimed to assess the efficacy of secukinumab in patients with moderate-to-severe hidradenitis suppurativa in two randomised trials. " 01/01/2023 - "Compared with the placebo group (57·1 [31%] of 183 patients), significantly more patients in the secukinumab every 2 weeks group (76·2 [42%] of 180 patients; 1·6 [1·1-2·6]; p=0·015) and the secukinumab every 4 weeks group (83·1 [46%] of 180 patients; 1·9 [1·2-3·0]; p=0·0022) had a hidradenitis suppurativa clinical response in the SUNRISE trial. "
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/01/2022 - "Hidradenitis suppurativa-Pitfalls of long-term immunosuppressive treatment with tumor necrosis factor (TNF)-α inhibitors." 01/01/2022 - "Author's Reply to Pestana et al. Comment on: "Is There a Role for Therapeutic Drug Monitoring in Patients with Hidradenitis Suppurativa on Tumor Necrosis Factor-α Inhibitors?"" 01/01/2022 - "Comment on: "Is There a Role for Therapeutic Drug Monitoring in Patients with Hidradenitis Suppurativa on Tumor Necrosis Factor-α Inhibitors?"" 03/01/2021 - "We sought to summarize the available evidence and to present the role of therapeutic drug monitoring and other dose optimization strategies in improving clinical response in patients with hidradenitis suppurativa treated with tumor necrosis factor-α inhibitors." 03/01/2021 - "Is There a Role for Therapeutic Drug Monitoring in Patients with Hidradenitis Suppurativa on Tumor Necrosis Factor-α Inhibitors?"
9.	Interleukin-17 (Interleukin 17)IBA 01/01/2022 - "The IL-17 pathway is a potential therapeutic target shown to be implicated in hidradenitis suppurativa (HS), however, it remains unclear whether evidence from mechanistic studies may translate into clinical practice. " 12/01/2023 - "The IL-17 pathways are involved in the pathophysiology of many inflammatory skin conditions, including hidradenitis suppurativa. " 11/16/2023 - "Aberrant expression of interleukin-17A in mast cells contributes to the pathogenesis of hidradenitis suppurativa." 11/16/2023 - "Interleukin-17A derived from mast cells: evidence for an autoinflammatory loop in hidradenitis suppurativa?" 10/11/2023 - "IL-17 Inhibition: A Valid Therapeutic Strategy in the Management of Hidradenitis Suppurativa."
10.	Isotretinoin (Accutane)FDA LinkGeneric 01/01/2009 - "Absence of efficacy of oral isotretinoin in hidradenitis suppurativa: a retrospective study based on patients' outcome assessment." 06/01/2021 - "Isotretinoin has been used off-label in hidradenitis suppurativa (HS) patients with variable results, making it difficult to predict which patients with HS are likely to benefit. " 06/01/2021 - "Isotretinoin in the treatment of hidradenitis suppurativa: a retrospective study." 10/01/2019 - "Could isotretinoin flare hidradenitis suppurativa? " 01/01/2019 - "Isotretinoin and hidradenitis suppurativa."

Therapies and Procedures

1.	Therapeutics 02/01/2020 - "Wide local excision is the gold standard and only potential curative therapy for recalcitrant hidradenitis suppurativa. " 11/01/2015 - "Given the absence of significant improvement in the treatment of hidradenitis suppurativa (HS) with traditional medical and surgical therapies, biologics have piqued the interest of research investigators. " 04/01/2011 - "The recent studies give us a better insight into the pathogenesis of hidradenitis suppurativa and should translate into improved therapies." 01/01/2022 - "LAight® Therapy Is an Effective Treatment Option to Maintain Long-Term Remission of Hurley I and II Hidradenitis Suppurativa: Results from Period B of RELIEVE, a Multicenter Randomized, Controlled Trial." 05/01/2013 - "The current gold standard therapy for hidradenitis suppurativa (HS) is surgical resection. "
2.	Photochemotherapy (Photodynamic Therapy) 04/01/2019 - "Surgery combined with photodynamic therapy in the treatment of disfiguring acne inversa: the efficacy of reconditioning." 05/01/2013 - "Efficacy of intralesional photodynamic therapy for the treatment of hidradenitis suppurativa." 08/01/2018 - "Several studies have been published since 2004 on the use of photodynamic therapy to treat hidradenitis suppurativa. " 01/01/2023 - "Systematic review of photodynamic therapy for the treatment of hidradenitis suppurativa." 09/01/2022 - "Effects of the modified excision combined with bidirectional photodynamic therapy on refractory hidradenitis suppurativa: a retrospective study."
3.	Bariatric Surgery 04/01/2018 - "Commentary on response to remission of hidradenitis suppurativa after bariatric surgery." 04/01/2018 - "Response to: Remission of hidradenitis suppurativa after bariatric surgery." 09/01/2017 - "Remission of hidradenitis suppurativa after bariatric surgery." 12/02/2023 - "Effects of bariatric surgery on severe suppurative hidradenitis: Results of a nationwide administrative data study in France." 06/02/2021 - "Impact of Bariatric Surgery on Hidradenitis Suppurativa."
4.	Biological Therapy 08/01/2016 - "Trials demonstrating the efficacy of biologic therapy for moderate to severe hidradenitis suppurativa (HS) have inspired new multidisciplinary treatment strategies. " 01/01/2019 - "Assessing the efficacy of new biologic therapies in hidradenitis suppurativa: consistency vs. bias in outcome measures in moderate and severe disease." 08/01/2018 - "A systematic review of the ClinicalTrials.gov database was searched for planned, in-progress, completed, or terminated trials investigating the effect of targeted biologic therapies for hidradenitis suppurativa (HS). " 01/01/2014 - "Several studies report the usefulness of different biological therapies in the management of a difficult-to-treat pathology such as hidradenitis suppurativa (HS). " 09/19/2023 - "Shorter time to initiation of biologic therapy in the setting of a hidradenitis suppurativa specialty clinic."
5.	Lasers (Laser) 01/01/2016 - "Lasers and intense pulsed light (IPL) treatment are useful for the treatment of hidradenitis suppurativa (HS). " 09/01/2023 - "We searched PubMed and Web of Science for "laser" and "hidradenitis suppurativa" on April 6, 2022. " 09/01/2023 - "Laser and intense pulsed light in the treatment of hidradenitis suppurativa." 04/01/2023 - "Laser speckle contrast analysis (LASCA): a new device in the diagnosis and monitoring of surgical treatment of hidradenitis suppurativa." 01/01/2023 - "Hidradenitis Suppurativa: Surgery, Lasers, and Emerging Techniques."