Hidradenitis Suppurativa

A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.

Also Known As:

Networked: 349 relevant articles (37 outcomes, 29 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Acne Vulgaris
2.	Pyoderma Gangrenosum
3.	Psoriasis (Pustulosis Palmaris et Plantaris)
4.	Crohn Disease (Crohn's Disease)
5.	Darier Disease (Darier's Disease)

Experts

1.	Jemec, Gregor B E: 10 articles (02/2015 - 01/2009)
2.	Jemec, G B E: 8 articles (06/2013 - 09/2002)
3.	Prens, E P: 6 articles (03/2015 - 01/2010)
4.	van der Zee, H H: 6 articles (03/2015 - 01/2010)
5.	Hamzavi, Iltefat H: 4 articles (11/2015 - 04/2010)
6.	Scheinfeld, Noah: 4 articles (02/2015 - 06/2013)
7.	Boer, Jurr: 4 articles (09/2014 - 01/2009)
8.	Prens, Errol P: 4 articles (09/2014 - 01/2009)
9.	Mekkes, J R: 4 articles (07/2012 - 02/2008)
10.	Join-Lambert, Olivier: 3 articles (01/2016 - 02/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hidradenitis Suppurativa:

1.	infliximab (Remicade)FDA Link 12/01/2007 - "Infliximab appears to be an effective medical approach to the management of hidradenitis suppurativa and also to prepare the patient for "curative" surgery. " 08/01/2012 - "Long-term efficacy of infliximab in hidradenitis suppurativa." 03/01/2011 - "Efficacy of infliximab for hidradenitis suppurativa: assessment of clinical and biological inflammatory markers." 09/01/2008 - "Efficacy of Infliximab treatment in patients with severe Fistulizing Hidradenitis Suppurativa." 02/01/2008 - "Long-term efficacy of a single course of infliximab in hidradenitis suppurativa."
2.	TNFR-Fc fusion protein (etanercept)FDA Link 04/01/2006 - "Etanercept: effective in the management of hidradenitis suppurativa." 03/01/2008 - "Etanercept is a safe and effective therapy for hidradenitis suppurativa and decreases the extent of the disease and improves the quality of life. " 06/01/2010 - "Long-term efficacy of etanercept in hidradenitis suppurativa: results from an open-label phase II prospective trial." 03/01/2008 - "An open-label phase II study of the safety and efficacy of etanercept for the therapy of hidradenitis suppurativa." 06/01/2010 - "To evaluate the long-term efficacy of etanercept for the management of hidradenitis suppurativa. "
3.	adalimumab (Humira)FDA Link 05/01/2012 - "A prospective open-label clinical trial of efficacy of the every week administration of adalimumab in the treatment of hidradenitis suppurativa." 08/01/2010 - "To evaluate the safety and efficacy of adalimumab for the management of hidradenitis suppurativa (HS). " 03/01/2009 - "Efficacy of adalimumab in recalcitrant hidradenitis suppurativa." 03/01/2013 - "Disparate results in studies of adalimumab in the treatment of hidradenitis suppurativa: comment on the article by Amano et al." 12/18/2012 - "Adalimumab for the treatment of moderate to severe Hidradenitis suppurativa: a parallel randomized trial."
4.	Isotretinoin (Accutane)FDA LinkGeneric 01/01/2009 - "Absence of efficacy of oral isotretinoin in hidradenitis suppurativa: a retrospective study based on patients' outcome assessment." 06/20/2012 - "Since he had begun a therapy with isotretinoin due to an acne inversa 3 weeks before, a possible association between the event and the treatment could not be excluded, and the case was reported to Swissmedic. " 10/01/1999 - "Long-term results of isotretinoin in the treatment of 68 patients with hidradenitis suppurativa." 01/01/1999 - "Oral isotretinoin has been used to treat mild to severe hidradenitis suppurativa (HS). " 01/01/1999 - "Long-term results of isotretinoin in the treatment of 68 patients with hidradenitis suppurativa."
5.	Anti-Bacterial Agents (Antibiotics)IBA 02/01/2011 - "Antibiotics have been shown to improve hidradenitis suppurativa (HS) patients but complete remission is rare using these treatments. " 11/01/2014 - "Bacteriology of hidradenitis suppurativa - which antibiotics are the treatment of choice?" 01/01/2009 - "Antibiotics are frequently used to treat hidradenitis suppurativa (HS); however, few data on their efficacy are available. " 07/01/2007 - "Hidradenitis suppurativa in 64 female patients: retrospective study comparing oral antibiotics and antiandrogen therapy." 01/01/2016 - "Although hidradenitis suppurativa (HS) is not primarily an infectious disease, antibiotics are widely used to treat HS. "
6.	Rifampin (Rifampicin)FDA LinkGeneric 01/01/2014 - "Dramatic reduction of clindamycin plasma concentration in hidradenitis suppurativa patients treated with the rifampin-clindamycin combination." 01/01/2009 - "The effect of combined treatment with oral clindamycin and oral rifampicin in patients with hidradenitis suppurativa." 01/01/2009 - "Combination therapy with clindamycin and rifampicin for hidradenitis suppurativa: a series of 116 consecutive patients." 05/01/2006 - "Clindamycin and rifampicin combination therapy for hidradenitis suppurativa." 01/01/2009 - "Combination treatment with oral rifampicin and clindamycin is a promising treatment option for hidradenitis suppurativa, despite the frequent occurrence of diarrhea as a side effect. "
7.	Clindamycin (Cleocin)FDA LinkGeneric 06/01/1983 - "Topical treatment of hidradenitis suppurativa with clindamycin." 06/01/1983 - "Thirty patients with recurrent suppurative hidradenitis entered a double blind trial to evaluate the effect of topical clindamycin against placebo in hidradenitis. " 12/01/1998 - "We compare topical clindamycin with systemic tetracycline in the treatment of hidradenitis suppurativa, and study clinical disease assessment. " 01/01/2014 - "Dramatic reduction of clindamycin plasma concentration in hidradenitis suppurativa patients treated with the rifampin-clindamycin combination." 01/01/2009 - "The effect of combined treatment with oral clindamycin and oral rifampicin in patients with hidradenitis suppurativa."
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/01/2015 - "Adherence to TNF-alpha inhibitors in patients with hidradenitis suppurativa." 01/01/2015 - "PsAPASH: a new syndrome associated with hidradenitis suppurativa with response to tumor necrosis factor inhibition." 02/01/2013 - "Predicting response to anti-TNF-alpha treatment in Hidradenitis suppurativa." 09/01/2011 - "Severe hidradenitis suppurative in an HIV-positive male: use of multiple treatment modalities, including tumor necrosis factor blockade." 12/01/2010 - "Several reports support the beneficial effect of tumor necrosis factor-α (TNF-α) antagonists for the treatment of severe hidradenitis suppurativa. "
9.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 04/01/2011 - "ALA PDT may be a safe and effective treatment of hidradenitis suppurativa." 09/01/2008 - "The studies reporting the use of PDT in hidradenitis suppurativa are reviewed. " 01/01/2009 - "These cases do not support the use of PDL-PDT for treating acne inversa." 01/01/2004 - "ALA-PDT and blue light therapy for hidradenitis suppurativa." 01/01/2009 - "We report the treatment of four consecutive acne inversa patients with pulse dye laser-mediated photodynamic therapy (PDL-PDT). "
10.	Cyproterone AcetateIBA 09/01/1986 - "A double-blind controlled cross-over trial of cyproterone acetate in females with hidradenitis suppurativa." 09/01/1986 - "Control of hidradenitis suppurativa in women using combined antiandrogen (cyproterone acetate) and oestrogen therapy." 09/01/1986 - "The effects of combined treatment with the antiandrogen, cyproterone acetate, and ethinyl oestradiol on four women with long-standing hidradenitis suppurativa have been investigated. " 09/01/1986 - "In order to examine whether anti-androgen therapy was effective in hidradenitis suppurativa (HS), ethinyloestradiol 50 micrograms/cyproterone acetate 50 mg in a reverse sequential regimen was compared with ethinyloestradiol 50 micrograms/norgestrel 500 micrograms (Eugynon 50) in 24 female patients. "

Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy) 05/01/2013 - "Efficacy of intralesional photodynamic therapy for the treatment of hidradenitis suppurativa." 04/01/2005 - "Photodynamic therapy using aminolaevulinic acid does not lead to clinical improvement in hidradenitis suppurativa." 01/01/2015 - "The use of photodynamic therapy to treat hidradenitis suppurativa a review and critical analysis." 07/01/2014 - "Our results suggest that photodynamic therapy with 5-aminolevulinic acid and a light wavelength of 635 nm could reduce disease severity and improve quality of life in patients with difficult-to-treat hidradenitis suppurativa." 07/01/2014 - "In this prospective study, we evaluated disease severity, quality of life, and treatment tolerance in 5 patients with moderate to severe hidradenitis suppurativa treated with photodynamic therapy using 5-aminolevulinic acid and a 635-nm light source. "
2.	Gas Lasers 03/01/1996 - "Carbon dioxide laser excision with second-intention healing is safe and effective for hidradenitis suppurativa." 08/01/2002 - "The aim of our study was to evaluate a surgical method for treatment of Hurley stage II hidradenitis suppurativa (HS), the carbon dioxide laser rapid-beam optomechanical scanner system in continuous mode. " 10/01/1994 - "The objective of our study was to evaluate a surgical method of management of patients with hidradenitis suppurativa (HS), using a CO2 laser technique for stepwise horizontal vaporization and peroperative monitoring of the removal of diseased tissue. " 02/01/2015 - "Recurrence rate and patient satisfaction of CO2 laser evaporation of lesions in patients with hidradenitis suppurativa: a retrospective study." 04/01/2012 - "Bacteriology of hidradenitis suppurativa exacerbations and deep tissue cultures obtained during carbon dioxide laser treatment."
3.	Lasers (Laser) 01/01/2016 - "Lasers and intense pulsed light (IPL) treatment are useful for the treatment of hidradenitis suppurativa (HS). " 01/01/2016 - "Lasers and Intense Pulsed Light Hidradenitis Suppurativa." 11/01/2015 - "Laser and light-based treatment options for hidradenitis suppurativa." 04/01/2015 - "The medical and laser management of hidradenitis suppurativa." 08/01/2011 - "Contemporary surgical treatment of hidradenitis suppurativa (HS) with a focus on the use of the diode hair laser in a case."
4.	Off-Label Use 05/01/2014 - "This article will review currently available data and reports on the off-label use of biologics in the treatment of cutaneous diseases other than psoriasis, including inflammatory dermal processes, autoimmune bullous skin diseases, connective-tissue diseases, and hidradenitis suppurativa (HS). " 11/01/2008 - "Numerous case reports featuring its off-label use suggest the drug could be helpful in treating hidradenitis suppurativa, pyoderma gangrenosum, Sweet's syndrome, cutaneous sarcoidosis, pemphigus, systemic vasculitides, multicentric reticulohistiocytosis and stomatitis." 10/01/2013 - "There are no currently FDA/EMEA-approved dermatologic indications for spironolactone and its off-label uses are, among others, female acne, female pattern hair loss, hidradenitis suppurativa or hirsutism. "
5.	Radiotherapy 06/01/2000 - "In a retrospective analysis the efficacy of radiotherapy in the treatment of hidradenitis suppurativa was assessed. " 01/01/2010 - "The role of radiotherapy in the treatment of hidradenitis suppurativa: case report and review of the literature." 06/01/2000 - "Radiotherapy should be given more consideration as a treatment option for hidradenitis suppurativa." 06/01/2000 - "Data from 231 patients undergoing radiotherapy for hidradenitis suppurativa in the last years in 2 hospitals were analyzed. " 06/01/2000 - "[Radiotherapy of hidradenitis suppurativa--still valid today?]."