Proton Pumps (Proton Pump)

Integral membrane proteins that transport protons across a membrane. This transport can be linked to the hydrolysis of ADENOSINE TRIPHOSPHATE. What is referred to as proton pump inhibitors frequently is about POTASSIUM HYDROGEN ATPASE.

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Networked: 2384 relevant articles (214 outcomes, 349 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fass, Ronnie: 23 articles (01/2014 - 01/2003)
2.	Howden, Colin W: 19 articles (12/2012 - 03/2003)
3.	Kinoshita, Yoshikazu: 15 articles (01/2015 - 08/2002)
4.	Dellon, Evan S: 14 articles (11/2015 - 07/2010)
5.	Kim, Nayoung: 14 articles (12/2014 - 08/2008)
6.	Haruma, Ken: 13 articles (12/2015 - 10/2007)
7.	Malfertheiner, P: 13 articles (04/2015 - 02/2000)
8.	Lee, Dong Ho: 12 articles (01/2016 - 08/2008)
9.	Molina-Infante, Javier: 12 articles (01/2016 - 03/2008)
10.	Fujiwara, Yasuhiro: 11 articles (07/2015 - 08/2004)

Related Diseases

1.	Gastroesophageal Reflux (GERD) 12/01/2005 - "While daily proton-pump inhibitor therapy remains the main treatment regimen option for most patients with gastro-oesophageal reflux disease, on-demand therapy may prove effective for many patients. " 09/06/2004 - "Large randomized clinical trials and >16 years of worldwide experience have confirmed the high rate of efficacy and excellent safety profile of proton pump inhibitor (PPI) therapy in individuals with all grades of GERD, making these agents the mainstay of treatment. " 06/01/2014 - "The notion that GERD and EoE can be distinguished by the response to proton pump inhibitor (PPI) treatment is based on the mistaken assumption that gastric acid suppression is the only important therapeutic effect of PPIs, and therefore only GERD can respond to PPIs. " 12/01/2006 - "Patients controlled on long-term proton pump inhibitor therapy for chronic gastroesophageal reflux disease are excellent surgical candidates and should experience improved symptom control after surgery at 1 year." 04/01/2011 - "Night-time intra-oesophageal bile and acid: a comparison between gastro-oesophageal reflux disease patients who failed and those who were treated successfully with a proton pump inhibitor."
2.	Infection 10/16/2007 - "Proton-pump inhibitor (PPI)-based triple therapy is the recommended first-line treatment for Helicobacter pylori infection. " 03/01/2001 - "Five-day proton pump inhibitor-based quadruple therapy regimen is more effective than 7-day triple therapy regimen for Helicobacter pylori infection." 03/01/2005 - "H pylori infection can be eradicated by antimicrobial therapy plus a proton pump inhibitor, but no treatment regimen is 100% effective. " 11/01/2003 - "This study compared the efficacy of an H2-receptor antagonist (H2RA)- and a proton-pump inhibitor (PPI)-based triple regimen for the eradication of Helicobacter pylori infection. " 12/01/2008 - "CYP2C19 polymorphisms have been inconsistently reported to associate with the efficacy of proton pump inhibitor (PPI)-based triple therapies for eradicating Helicobacter pylori infection. "
3.	Ulcer 01/01/1992 - "The proton pump inhibitor (PPI), significantly more potent and long-acting than H2-blocker, is expected to be more effective for postoperative recurrent ulcers. " 11/21/2014 - "Two-wk treatment with a proton pump inhibitor is as effective as four-week treatment for healing post ESD ulcers." 01/01/2013 - "Several trials have shown the efficacy of 4 or 8 weeks of proton pump inhibitor (PPI) administration for post-ESD ulcers. " 03/01/2010 - "Several trials have shown the efficacy of 4 or 8 weeks of proton pump inhibitor (PPI) administration for post-ESD ulcers. " 03/01/2009 - "In all cases with benign ulcers, follow-up endoscopy performed 6 weeks after proton-pump-inhibitor treatment revealed that the ulcer had improved without antifungal medication. "
4.	Peptic Ulcer (Peptic Ulcers) 11/01/2011 - "Management of these factors may prove effective in managing marginal ulcers, and tailoring postoperative proton pump inhibitor therapy to patients with multiple risk factors could be effective." 09/01/2005 - "Review: 7-day proton-pump inhibitor-based triple therapy is as effective as > 7 days of the same regimen for healing Helicobacter pylori-associated peptic ulcer." 11/01/2010 - "Proton pump inhibitor (PPI) is an effective and safe medication for the elderly people for the treatment of peptic ulcer disease. " 06/15/2005 - "Two studies with a total of 385 patients compared eradication vs. a proton pump inhibitor; five of 196 (2.6%) developed a peptic ulcer in the eradicated group vs. zero of 189 (0%) in the proton pump inhibitor group (odds ratio = 7.43; 95% confidence interval: 1.27-43.6). " 01/01/1999 - "pylori eradication for the treatment of peptic ulcer disease, a randomized controlled trial to compare the efficacy of proton pump inhibitor-based dual and triple regimens was conducted. "
5.	Hemorrhage 12/01/2007 - "However, there are few reports on whether a proton pump inhibitor or a histamine2-receptor antagonist is the more effective treatment for preventing bleeding after ESD. " 01/01/2016 - "Despite the source of the bleeding, acid suppression with a proton-pump inhibitor has been shown to be effective in minimizing rebleeding. " 04/06/2010 - "The efficacy of large-dose proton pump inhibitor (PPI) therapy in reducing re-bleeding after endoscopic therapy has been supported by evidence derived from randomized controlled trials. " 07/01/2015 - "High Dose Proton Pump Inhibitor Infusion Versus Bolus Injection for the Prevention of Bleeding After Endoscopic Submucosal Dissection: Prospective Randomized Controlled Study." 08/14/2014 - "Using proton pump inhibitor protection rates of 50%-85% from published studies, an estimation of 13% to 22% of the total number of the hospitalizations due to PUD or EG/ED related bleeding may have been preventable. "

Related Drugs and Biologics

1.	Omeprazole (Esomeprazole)
2.	Amoxicillin (Wymox)
3.	lansoprazole (Prevacid)
4.	Clarithromycin (Biaxin)
5.	Ranitidine (Zantac)
6.	Anti-Bacterial Agents (Antibiotics)
7.	rabeprazole (Aciphex)
8.	pantoprazole (Protonix)
9.	Metronidazole (Metric)
10.	Aspirin (Acetylsalicylic Acid)

Related Therapies and Procedures

1.	Fundoplication
2.	Gastrectomy
3.	Oral Administration
4.	Ligation
5.	Drug Therapy (Chemotherapy)