HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

CD45 Antigens (CD45 Antigen)

Subscribe to New Research on CD45 Antigens

High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.

Also Known As:

CD45 Antigen; Antigens, CD45; 2H4 Antigens; B220 Antigen; B220 Antigens; CD45R0 Antigens; CD45RB Antigens; CD45RCAntigens; L-CA Antigens; Leukocyte Common Antigen; T200 Antigens; Antigen, B220; Antigen, CD45; Antigen, Leukocyte Common; Antigens, 2H4; Antigens, B220; Antigens, CD45R; Antigens, CD45R0; Antigens, CD45RA; Antigens, CD45RB; Antigens, CD45RO; Antigens, L-CA; Antigens, Leukocyte Common; Antigens, T200; L CA Antigens; CD45R Antigens; CD45RA Antigens; CD45RO Antigens; Leukocyte Common Antigens; Protein Tyrosine Phosphatase, Receptor Type, C

Networked: 289 relevant articles (6 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ro, Jae Y: 3 articles (01/2009 - 01/2002)
2.	Thude, H: 2 articles (02/2010 - 12/2004)
3.	Barz, D: 2 articles (02/2010 - 12/2004)
4.	Pagel, John M: 2 articles (01/2009 - 08/2008)
5.	Gopal, Ajay K: 2 articles (01/2009 - 08/2008)
6.	Press, Oliver W: 2 articles (01/2009 - 08/2008)
7.	Ayala, Alberto G: 2 articles (01/2009 - 01/2002)
8.	Siegel, S E: 2 articles (07/2001 - 05/2000)
9.	Kaiser, H E: 2 articles (07/2001 - 05/2000)
10.	Bodey, B: 2 articles (07/2001 - 05/2000)

Related Diseases

1.	Lymphoma (Lymphomas) 02/01/2010 - "Immunohistochemical study showed positivity for leukocytic common antigen (CD45), B-cell marker (CD20) and bcl 6. The patient underwent full staging for lymphoma showing no evidence of extra-testicular involvement by lymphoma and no lymph nodes. " 01/01/1999 - "An immunohistochemical study showed that the lymphoma cells were positive for leukocyte common antigen, Epstein-Barr virus, bax. " 09/01/2009 - "The lymphoma cells were positive for leukocyte common antigen, CD79a, CD138, Epstein-Barr virus (EBV) and kappa light chain restriction and negative for CD20, CD3, S100, HMB45 and cytokeratins. " 03/01/1997 - "Lymphoma cells are positive for leukocyte common antigen and L-26, indicating a B cell phenotype. " 11/01/1993 - "No lesions other than lymphoma were leukocyte-common antigen (LCA) positive; all but two lymphomas were LCA positive, while all but one lymphoma were L26 positive. "
2.	Melanoma (Melanoma, Malignant) 01/01/1994 - "We further observed that in early lesions (< 0.75 mm) of superficial spreading melanoma the vast majority of tumor-infiltrating lymphocytes (TIL) belong to the CD4+ subset and frequently express CD45RA antigens. " 03/15/1988 - "Treatment of melanoma patients with CY plus vaccine resulted in a progressive fall in the proportion of CD4+ T-cells expressing the 2H4 (CD45) antigen, which identifies inducers of suppression. " 11/01/1986 - "Lymphomas and malignant melanomas were excluded by immunohistochemical staining for leukocyte common antigen and S100 protein respectively. " 03/01/2006 - "In total, 74 lesions (12 BN, 12 MDN, 13 RGP-CMM, 26 VGP-CMM, and 11 metastatic melanomas) were examined using immunoperoxidase staining methods and antibodies targeting leukocyte common antigen (LCA+), T (CD3+) and B (CD20+) lymphocytes, and resting cytotoxic T cells (TIA-1+). " 01/01/1996 - "S-100 protein and leukocyte common antigen were helpful in ruling out melanoma and lymphoma. "
3.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 12/01/2004 - "A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population." 02/01/2002 - "A point mutation in the leukocyte common antigen (CD45, C-->G77, exon 4) was investigated in patients with type 1 diabetes (IDDM), patients with Graves' disease and controls. " 01/01/2001 - "The alterations of CD45RA and CD45RO antigens expression on T helper cells in prediabetics suggest the significant role of naive or/and memory CD4+ T cell subsets in the pathogenesis of diabetes type 1. It could be suggested that CD4+CD45RA+/CD4+CD45RO+ ratio could serve as surrogate marker of diabetes type 1 risk development and presumably for estimation of the efficacy of the preventive procedures in subjects at high risk of IDDM, but further prospective studies are needed." 01/01/1999 - "The number of CD4+ T lymphocytes co-expressing CD45RA and CD45RO antigens were statistically higher in the patients with recently diagnosed insulin-dependent diabetes mellitus. " 01/01/1999 - "The aim of the present study was to evaluate the differences between the distribution of memory, naive and recently activated T cells (co-expressing both CD45RA and CD45RO antigens) in the peripheral blood of patients with newly diagnosed Graves' disease and insulin-dependent diabetes mellitus in comparison to healthy controls. "
4.	Carcinoma (Carcinomatosis) 08/01/2007 - "Leucocyte common antigen (CD45) and CD5 positivity in an "undifferentiated" carcinoma: a potential diagnostic pitfall." 06/01/1998 - "The method is based on the fact that the peripheral blood mononuclear cells (PBMC) that express CD45 antigen are trapped with anti-CD45 conjugated supramagnetic microbeads while the carcinoma cells that do not express CD45 antigen are not trapped and pass through the magnetic fields. " 11/01/1989 - "Expression of MHC class II, interleukin 2 receptor and CD45 antigens on tumour-associated T lymphocytes in colonic carcinoma." 04/01/1989 - "The immunohistochemistry of biopsy specimens pointed to a diagnosis of carcinoma, the tumor cells being cytokeratin positive and leukocyte common antigen (LCA) negative. " 07/01/1988 - "When distinguishing lymphomas from poorly differentiated carcinomas, this method provided much better morphologic differentiation and better demonstration of leukocyte common antigen than keratin staining. "
5.	Inflammation 03/01/1991 - "Leukocyte common antigen and UCHL1 staining was helpful in identifying islet inflammation. " 12/01/2010 - "We quantified, by immunohistochemical means, the PF inflammation in 39 autopsy cases by counting leukocyte common antigen (LCA)-positive cells. " 01/01/2002 - "On immunohistochemistry, leukocyte common antigen was positive, confirming the presence of inflammation. " 01/01/2013 - "Cellular inflammation was quantified by flow-cytometric evaluation of retinal tissue using the myeloid marker CD11b and leukocyte common antigen CD45 to differentiate and quantify CD11b+/CD45low microglia, CD11b+/CD45hi myeloid leukocytes and CD11bneg/CD45hi lymphocytes. " 05/01/2008 - "All of the patients with ulcer had extensive inflammation on bladder biopsy including severe mononuclear cell infiltration, moderate or strong interleukin-6 staining in the urothelium and lamina propria, and leukocyte common antigen staining in more than 10% of the lamina propria. "

Related Drugs and Biologics

1.	CD45 Antigens (CD45 Antigen)
2.	Keratins (Keratin)
3.	Antibodies
4.	S100 Proteins (S 100 Protein)
5.	Muramidase (Lysozyme)
6.	von Willebrand Factor
7.	Biological Markers (Surrogate Marker)
8.	Pancreatic Elastase (Elastase)
9.	Glycoproteins (Glycoprotein)
10.	Ethanol (Ethyl Alcohol)

Related Therapies and Procedures

1.	Radioimmunotherapy
2.	Homologous Transplantation (Allograft)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Microspheres (Microsphere)
5.	Immunotherapy