Seborrheic Keratosis

12/01/2023 - "Topical hydrogen peroxide shows the greatest evidence for clinical clearance of seborrheic keratoses and may be a viable option for patients requesting noninvasive removal. "
10/01/2018 - "Anatomic Site-Specific Treatment Response With 40% Hydrogen Peroxide (w/w) Topical Formulation for Raised Seborrheic Keratoses: Pooled Analysis of Data from Two Phase 3 Studies."
09/01/2022 - "Utility of 30% hydrogen peroxide in the treatment of seborrheic keratosis."
01/01/2021 - "A systematic literature review was performed using the terms "Eskata AND seborrheic keratosis," and "hydrogen peroxide AND seborrheic keratosis" in the OVID MEDLINE, PubMed, Cochrane Library, EMBASE, and Web of Science databases. "
01/01/2021 - "Hydrogen peroxide 40% (HP40) was approved by the US Food and Drug Administration for topical treatment of seborrheic keratosis (SK) in December 2017. "

07/01/2019 - "Enhancing Outcomes in Seborrheic Keratosis: Using a Novel Treatment Solution"
12/01/2020 - "Assess participants’ satisfaction following treatment with a proprietary hydrogen peroxide topical solution 40%, w/w (HP40) for raised seborrheic keratoses (SKs). "
12/01/2020 - "Assessing Patients' Satisfaction With Hydrogen Peroxide Topical Solution, 40% for Treatment of Raised Seborrheic Keratoses."
01/01/2020 - "HP40 (Eskata™) is a stabilized, topical solution of 40% hydrogen peroxide (H2O2) packaged in an applicator pen that is US FDA-approved to treat seborrheic keratoses (SKs). "
01/01/2020 - "Hydrogen Peroxide Topical Solution, 40% (w/w) for the Treatment of Seborrheic Keratoses: A Review"

11/01/2018 - "Safety and efficacy of hydrogen peroxide topical solution, 40% (w/w), in patients with seborrheic keratoses: Results from 2 identical, randomized, double-blind, placebo-controlled, phase 3 studies (A-101-SEBK-301/302)."
03/01/2018 - "A-101, a Proprietary Topical Formulation of High-Concentration Hydrogen Peroxide Solution: A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile in Subjects With Seborrheic Keratosis of the Face."
10/01/2018 - "Ex vivo evaluation of cytotoxicity and melanocyte viability after A-101 hydrogen peroxide topical solution 40% or cryosurgery treatment in seborrheic keratosis lesions."

01/01/2020 - "Unusual clinical manifestation of seborrheic keratosis on the scalp successfully treated with topical trichloroacetic acid: an atypical case report."
01/01/2021 - "Hydrogen peroxide produced greater clearance of seborrheic keratosis (P=0.017) than trichloroacetic acid. "
01/01/2021 - "This study compared the efficacy of 30% hydrogen peroxide versus 50% trichloroacetic acid in treatment of seborrheic keratoses. "
01/01/2021 - "Comparison of efficacy and safety of 30% hydrogen peroxide with 50% trichloroacetic acid in seborrheic keratosis: a randomized controlled study."
01/01/2021 - "Application of 30% hydrogen peroxide appears to be more efficacious as compared to trichloroacetic acid (50%) for treatment of seborrheic keratosis."

02/01/1990 - "Lac-Hydrin 12% lotion significantly reduced the height (elevation) of seborrheic keratoses, and two seborrheic keratoses cleared completely; however, there was no statistically significant difference in the length, color, and surface characteristics between the study group and the control group. "
02/01/1990 - "A double-blind, paired comparison study was used to evaluate treatment effects of 12% ammonium lactate lotion (Lac-Hydrin) against its vehicle on seborrheic keratoses. "

05/30/2017 - "In order to investigate and characterize the presence of recurrent mutations, we performed exome sequencing on DNA from one seborrheic keratosis lesion and corresponding blood cells from the same patients with follow up investigation of alterations identified by exome sequencing in 24 additional lesions from as many patients. "
10/01/2001 - "Absence of human papillomavirus DNA in nongenital seborrheic keratosis."
02/01/1993 - "Reverse blot hybridization indicated the presence of DNA related to the HPV-5 group of papillomaviruses in seborrheic keratoses in three patients. "
11/01/1992 - "We searched for HPV DNA in 72 cases of seborrheic keratosis (nongenital SK 29, genital SK 43) using polymerase chain reaction. "
11/01/1992 - "Detection of human papillomavirus DNA in seborrheic keratosis by polymerase chain reaction."

05/01/2014 - "Indeed, the dermoscopy findings might be related to the melanin-rich necrotic cells in the epidermis, which are quite different from dermoscopy findings of clonal seborrheic keratosis. "
01/01/1987 - "No homogeneous inclusions typical of melanin macroglobules ("giant melanosomes") were found in any of the specimens, supporting the view that neither patterned nor nonpatterned seborrheic keratoses are nevoid in nature."
08/01/2004 - "In contrast, in pigmented seborrheic keratosis (SK), a similarly pigmented epidermal tumor, the distribution of melanin granules does not differ between the lesional ( approximately 93.9%) and the perilesional normal epidermis ( approximately 92.2 %), indicating that interrupted melanosome transfer occurs in BCE but not in all pigmented epithelial tumors. "
01/01/2018 - "The cause of hyperpigmentation, such as solar lentigo and seborrheic keratosis, is the excessive accumulation of melanin pigments in the epidermal basal layer. "
07/10/2020 - "Melanin-related compounds in paraffin-embedded tissue specimens of basal cell carcinoma (BCC), seborrheic keratosis (SK), malignant melanoma (MM), and nevus pigmentosus (NP) were nondestructively investigated using permeability measurements (light penetration into pigmented lesion), X-band (9.4 GHz) electron paramagnetic resonance (EPR), and EPR imaging (EPRI). "

05/01/2015 - "DPN is considered to be a form of seborrheic keratosis with a specific localization and it is less frequently described in the white population. "
10/01/2020 - "Dermatosis papulosa nigra (DPN) is characterized by the presence of multiple, small, hyperpigmented, warty papules affecting the face, neck, and trunk that bear to histological semblance to seborrheic keratosis. "
07/01/2011 - "Dermatosis papulosa nigra (DPN) and pedunculated seborrheic keratoses (PSK) had characteristic CL and FR in both of them. "
12/01/2010 - "Dermatosis papulosa nigra (DPN) is a common variant of seborrheic keratoses in darkly pigmented individuals. "
05/01/2015 - "Pulsed dye laser (PDL) has traditionally been used to treat vascular lesions, but it has been shown to be effective in treatment of lentigines, ephelides, seborrheic keratosis, and rarely DPN. "

01/01/2021 - "Large Seborrheic Keratosis of the Auricle Treated With Liquid Nitrogen Therapy."
06/01/1985 - "Liquid nitrogen spray followed by light electrodesiccation treatment is helpful in the management of flat warts, small skin tags, seborrheic keratoses, and cherry angiomas. "
04/01/1992 - "Full face liquid nitrogen cryo spraying of actinically damaged skin accomplishes not only depth-controlled destruction of individual actinic keratoses, but also destruction of surrounding, barely perceptible actinic keratoses, removal of unsightly pigmented surfaces, and removal of seborrheic keratoses and large lentigines. "
07/01/2017 - "Liquid nitrogen cryotherapy is a commonly used technique to treat a wide variety of dermatologic conditions including actinic keratoses, non-melanoma skin cancers, verrucae, and seborrheic keratoses. "
04/01/1999 - "A rapidly spreading plaque of seborrheic keratosis developed following liquid nitrogen treatment and involuted quietly after a dermatitis developed; polymerase chain reaction of the tissue did not demonstrate papillomavirus DNA. "

05/01/2016 - "Diclofenac gel may be a new treatment option for seborrheic keratosis."
11/01/2020 - "In 2016, a case of seborrheic keratosis was successfully treated with diclofenac gel 3%. "
11/01/2020 - "Comparative evaluation of topical diclofenac sodium versus topical ibuprofen in the treatment of seborrheic keratosis."

08/01/2008 - "The current knowledge about seborrheic keratosis with respect to epidemiology, pathogenesis, diagnosis and therapy is summarized."
04/01/2004 - "Patients with seborrheic keratoses frequently desire an effective topical therapy for seborrheic keratoses. "
06/01/2003 - "Awareness of these changes in seborrheic keratosis will avoid misdiagnosis and excessive therapy."
01/01/2021 - "Efficacy of Microplasma Radiofrequency Versus CO2 Laser Therapy for Seborrheic Keratoses: A Randomized, Intraindividual Comparative Study."
01/01/2017 - "These results showed that ATRA-MN treatment is promising as a safe and effective therapy for seborrheic keratosis and senile lentigo."

08/01/2014 - "Therapeutic efficacy of long-pulsed 755-nm alexandrite laser for seborrheic keratoses."
08/01/2014 - "A total of 216 seborrheic keratoses were treated with a mean 1.1 ± 0.4 sessions of long-pulsed 755-nm alexandrite laser and achieved a mean objective improvement score of 3.4 ± 0.7. Morphologic factors significantly impacted the number of treatment sessions required; in particular, papular lesions seemed to require more repetitive long-pulsed 755-nm alexandrite laser treatments than macular lesions. "
08/01/2014 - "A total of 216 seborrheic keratoses in 13 patients were treated with one or three sessions of long-pulsed 755-nm alexandrite laser at 1-month intervals. "
08/01/2014 - "We analysed treatment outcomes and adverse events in the treatment of seborrheic keratoses using a long-pulsed 755-nm alexandrite laser without colour enhancement. "
05/01/2002 - "The alexandrite laser was used in one patient to quickly and efficiently destroy hundreds of seborrheic keratoses. "

09/01/2016 - "Treatment of seborrheic keratosis in bilateral external auditory canal using fiber CO2 laser."
09/01/2004 - "After informed consent, 16 patients with seborrheic keratosis, who required CO2 laser surgery, were enrolled. "
01/01/2021 - "Efficacy of Microplasma Radiofrequency Versus CO2 Laser Therapy for Seborrheic Keratoses: A Randomized, Intraindividual Comparative Study."
01/01/2021 - "Efficacy and safety of cryotherapy, electrodesiccation, CO2 laser, and Er:YAG laser in the treatment of seborrheic keratosis."
12/01/2021 - "Photodynamic therapy combined with carbon dioxide laser for successful treatment of cutaneous squamous cell carcinoma within a long-standing and huge seborrheic keratosis."

04/01/2004 - "Fifteen patients with numerous seborrheic keratoses were enrolled in an open-label study comparing cryosurgery with topical agents. "
09/01/2019 - "Patient Preferences and Comparative Outcomes Regarding Cryosurgery versus Electrodesiccation in the Removal of Truncal Seborrheic Keratoses."
05/01/2014 - "Notably, HAS is sometimes misdiagnosed and treated by cryosurgery as seborrheic keratosis, which could trigger the later development of porocarcinoma. "
04/01/2004 - "Cryosurgery produces clinical and histological improvement of seborrheic keratoses. "
10/01/2015 - "Effectiveness of erbium:YAG laser and cryosurgery in seborrheic keratoses: Randomized, prospective intraindividual comparison study."

08/01/2023 - "Comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: A randomized controlled trial."
02/15/2019 - "It is important to remain vigilant of this diagnosis, as treatment for inflamed seborrheic keratosis often includes a trial of cryotherapy, which potentially could lead to a delayed diagnosis of an underlying malignant lesion."
12/01/2019 - "In a concentration of 40%, H2O2 is US Food and Drug Administration-approved to treat seborrheic keratoses and may cause fewer pigmentary changes than cryotherapy, although elimination often requires 2 to 4 treatments. "
02/15/2003 - "Common treatments for acrochordons and seborrheic keratoses are cryotherapy and shave excision. "
01/01/2021 - "Efficacy and safety of cryotherapy, electrodesiccation, CO2 laser, and Er:YAG laser in the treatment of seborrheic keratosis."