Ankyrins

A family of membrane-associated proteins responsible for the attachment of the cytoskeleton. Erythrocyte-related isoforms of ankyrin attach the SPECTRIN cytoskeleton to a transmembrane protein (ANION EXCHANGE PROTEIN 1, ERYTHROCYTE) in the erythrocyte plasma membrane. Brain-related isoforms of ankyrin also exist.

Also Known As:

Networked: 334 relevant articles (1 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mohler, Peter J: 30 articles (02/2015 - 02/2003)
2.	Geppetti, Pierangelo: 15 articles (07/2015 - 01/2010)
3.	Hund, Thomas J: 14 articles (02/2015 - 10/2008)
4.	Bennett, Vann: 13 articles (08/2015 - 02/2003)
5.	Nassini, Romina: 13 articles (07/2015 - 01/2010)
6.	Materazzi, Serena: 12 articles (07/2015 - 01/2010)
7.	Gallagher, Patrick G: 8 articles (03/2011 - 09/2005)
8.	Fusi, Camilla: 7 articles (07/2015 - 01/2012)
9.	Patacchini, Riccardo: 6 articles (07/2015 - 01/2010)
10.	Trevisan, Gabriela: 6 articles (01/2015 - 08/2013)

Related Diseases

1.	Acute Erythroblastic Leukemia (Erythroleukemia) 01/01/2015 - "Inclusion of a single copy of the Ankyrin insulator did not affect viral titer, and improved the consistency of expression from the vector in murine erythroleukemia cells. " 05/01/1993 - "After the onset of band 3 expression in human erythroleukemia cells, an increase of membrane-associated fluorescence was detectable for both ankyrin and spectrin, supporting the general view that band 3 promotes assembly of the membrane cytoskeleton. " 05/01/1993 - "Different sequences of expression of band 3, spectrin, and ankyrin during normal erythropoiesis and erythroleukemia." 05/01/1993 - "These findings indicate that the current concept of a sequential expression of spectrin/ankyrin and band 3 is valid only for erythroleukemia cells or transformed erythropoietic cell lines but does not occur in normal erythropoiesis, during which these proteins become expressed simultaneously." 05/01/1993 - "Expression of the erythrocyte anion exchanger band 3, and ankyrin and spectrin, two cytoskeletal proteins of the red blood cell membrane, was studied by immunofluorescence using: 1) smears of human bone marrow from healthy donors and from a patient with erythroleukemia, 2) human red blood cell precursors grown in cell culture, and 3) murine erythroleukemia cells grown in cell culture. "
2.	Lymphoma (Lymphomas) 09/25/1991 - "Post-translational protein modification and expression of ankyrin-binding site(s) in GP85 (Pgp-1/CD44) and its biosynthetic precursors during T-lymphoma membrane biosynthesis." 06/01/1986 - "Most importantly, in intact lymphoma cells this ankyrin-like protein is localized directly underneath the plasma membrane and is found to be preferentially accumulated beneath receptor cap structures as well as associated with a membrane-cytoskeleton complex preparation. " 06/01/1986 - "A lymphoma plasma membrane-associated protein with ankyrin-like properties." 12/15/1993 - "The purposes of this study are to characterize the binding of hyaluronic acid (HA) to mouse T lymphoma cells, to measure changes in intracellular Ca2+ after HA binding, to elucidate the interaction between the HA receptor, GP85(CD44), and ankyrin in the membrane skeleton, and finally to correlate these events with HA receptor patching/capping and cell adhesion to HA. " 09/25/1991 - "In this study, we have investigated the biosynthesis and processing of GP85 (Pgp-1/CD44), a lymphoma transmembrane glycoprotein known to contain ankyrin-binding site(s). "
3.	Hereditary Spherocytosis 03/01/2011 - "We previously identified a mutation in the human Ankyrin-1 (ANK-1) promoter that causes the disease ankyrin-deficient Hereditary Spherocytosis (HS). " 02/01/2011 - "A new ankyrin mutation (ANK1 EXON E9X) causing severe hereditary spherocytosis in the neonatal period." 07/01/2010 - "We previously identified a dinucleotide deletion in the human ankyrin-1 gene (ANK-1) promoter that underlies ankyrin-deficient hereditary spherocytosis. " 10/01/2008 - "Ankyrin-linked hereditary spherocytosis in an African-American kindred." 06/15/2007 - "Defects in erythrocyte ankyrin are the most common cause of typical, dominant hereditary spherocytosis (HS). "
4.	Neoplasms (Cancer) 05/01/2000 - "In this study, we focused on the functional domain in ankyrin (in particular, the ankyrin repeat domain [ARD]) responsible for CD44 binding and its role in regulating HA-mediated ovarian tumor cell function. " 01/01/1998 - "To study the role of CD44s-ankyrin interaction in regulating human prostate tumor cells, we have constructed several CD44s cytoplasmic deletion mutants that lack the ankyrin-binding site(s). " 05/19/2011 - "POTE ankyrin domain family, member H (POTEH) belongs to POTE family, which expresses in many cancers. " 08/01/2008 - "This article reviews the current evidence for HA/CD44-mediated activation of the ankyrin-based cytoskeleton and RhoGTPase signaling during tumor progression. " 06/20/2008 - "Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells."
5.	Bipolar Disorder (Mania) 04/01/2015 - "Polymorphisms at the rs10994336 and rs9804190 loci of the Ankyrin 3 (ANK3) gene have been strongly associated with increased risk for bipolar disorder (BD). " 04/01/2014 - "Genetic variants within the ankyrin 3 gene (ANK3) have been identified as a risk factor for bipolar disorder. " 08/01/2013 - "Several genome-wide association studies for bipolar disorder (BD) have found a strong association of the Ankyrin 3 (ANK3) gene. " 04/01/2013 - "Ankyrin 3 (ANK3) has been strongly implicated as a risk gene for bipolar disorder (BD) by recent genome-wide association studies of patient populations. " 12/01/2012 - "Genome-wide association studies (GWAS) recently identified ankyrin 3 (ANK3) as a candidate gene for bipolar disorder type I (BPD-I). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Calcium Channels (Calcium Channel)
3.	Spectrin
4.	DNA (Deoxyribonucleic Acid)
5.	Ion Channels (Ion Channel)
6.	Membrane Proteins (Integral Membrane Proteins)
7.	Protein Isoforms (Isoforms)
8.	Hyaluronic Acid (Hyaluronan)
9.	Inositol 1,4,5-Trisphosphate Receptors (Inositol Triphosphate Receptor)
10.	Glycoproteins (Glycoprotein)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Defibrillators (Defibrillator)
3.	Splenectomy
4.	Lasers (Laser)
5.	Intraperitoneal Injections