Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)

Specific receptors on cell membranes that react with PLATELET-DERIVED GROWTH FACTOR, its analogs, or antagonists. The alpha PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA) and the beta PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA) are the two principle types of PDGF receptors. Activation of the protein-tyrosine kinase activity of the receptors occurs by ligand-induced dimerization or heterodimerization of PDGF receptor types.

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Networked: 2175 relevant articles (78 outcomes, 228 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Heinrich, Michael C: 18 articles (10/2021 - 05/2002)
2.	Fidler, Isaiah J: 18 articles (01/2009 - 11/2002)
3.	Ostman, Arne: 15 articles (01/2019 - 10/2002)
4.	Kitadai, Yasuhiko: 15 articles (10/2017 - 11/2005)
5.	Schöffski, Patrick: 13 articles (10/2021 - 04/2006)
6.	Kazlauskas, Andrius: 13 articles (01/2016 - 09/2002)
7.	Mathew, Paul: 13 articles (07/2013 - 03/2003)
8.	von Mehren, Margaret: 12 articles (10/2021 - 07/2003)
9.	Pietras, Kristian: 12 articles (01/2019 - 10/2002)
10.	Heldin, Carl-Henrik: 11 articles (12/2018 - 10/2002)

Related Diseases

1.	Neoplasms (Cancer) 12/20/2013 - "Inhibition of PDGF receptor signaling has proven to useful for the treatment of patients with certain rare tumors. " 12/20/2013 - "Whether treatment with PDGF/PDGF receptor antagonists will be beneficial for more common malignancies is the subject for ongoing studies. " 01/01/2022 - "Pharmacologic targeting of METTL3 augments anti-tumor efficacy of PDGF receptor (PDGFR) and mitophagy inhibitors in vitro and in vivo. " 01/01/2021 - "Meanwhile, the improved penetrability of DI-MPL in tumor tissue was found to be related to the reduced IFP, which is achieved via inhibiting expression of phosphorylated platelet-derived growth factor receptor-β (p-PDGFR-β) by IM. " 01/01/2022 - "Studies have shown that platelet-derived growth factor receptor α (PDGFRA) is an essential target to treat tumors and inhibiting the activity of PDGFRA can improve the prognosis of HGG. "
2.	Fibrosis (Cirrhosis) 12/01/2008 - "RNA interference targeting the platelet-derived growth factor receptor beta subunit ameliorates experimental hepatic fibrosis in rats." 11/01/2008 - "Targeted inhibition of platelet-derived growth factor receptor-beta subunit in hepatic stellate cells ameliorates hepatic fibrosis in rats." 04/30/2023 - "Platelet-derived growth factor receptor β (PDGFRβ) plays an important role in hepatic fibrosis and is closely associated with hepatic stellate cells (HSCs) activation. " 05/01/2022 - "Modulating cMSC PDGF receptor expression may thus represent a novel approach to limit pathologic cardiac fibrosis in HF." 01/01/2022 - "Since C5aR1 was also detected in a small population of platelet-derived growth factor receptor-β+ GFP+ cells, we developed C5ar1fl/fl.Foxd1Cre+/- mice, in which C5aR1 is deleted specifically in pericytes, and found reduced FA-induced fibrosis. "
3.	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 07/01/2016 - "Molecular and Immunohistochemical Study of Platelet Derived Growth Factor Receptor Alpha in KIT Negative Gastrointestinal Stromal Tumors; the First Report from Iran." 05/01/2011 - "To study the immunophenotype and c-kit or platelet derived growth factor receptor alpha (PDGFRA) gene mutations in CD117-negative gastrointestinal stromal tumors (GISTs). " 09/01/2008 - "To analyze the frequency and spectrum of KIT and platelet-derived growth factor receptor-alpha (PDGFRA) gene in a large series of study and to explore the clinical implication of mutations in the gastrointestinal stromal tumors (GISTs) in China. " 06/01/2006 - "The goal of this study was to investigate the association of mutations in the KIT gene and the platelet-derived growth factor receptor alpha (PDGFRA) gene with clinicopathological features of patients with gastrointestinal stromal tumor (GIST) localized in the stomach. " 10/19/2023 - "Gastrointestinal stromal tumor is known to be associated with alterations in the c-KIT and platelet-derived growth factor receptor genes and, if resectable, is treated in accordance with the modified Fletcher classification. "
4.	Sarcoma (Soft Tissue Sarcoma) 01/01/2017 - "Several studies have shown that platelet-derived growth factor receptor α (PDGFRα) gene amplification is frequently observed in pulmonary artery sarcoma. " 06/19/2018 - "Platelet-derived growth factor receptor-α and -β promote cancer stem cell phenotypes in sarcomas." 01/01/2017 - "As sarcomas are rare in CDKN2A/p16INK4A carriers, we searched in constitutional WES of nine carriers for potential modifying rare variants and identified three in platelet-derived growth factor receptor (PDGFRA) gene. " 01/01/2017 - "Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α." 08/01/2015 - "Intimal sarcoma of the abdominal aorta with platelet-derived growth factor receptor α overexpression and amplification in mural invasive cells and pulmonary metastatic cells but not in intimal spreading cells."
5.	Hepatocellular Carcinoma (Hepatoma) 06/13/2017 - "Platelet-derived growth factor receptor alpha (PDGFRα) is suggested as a prognosis marker for hepatocellular carcinoma (HCC). " 12/15/2005 - "Furthermore, immunohistochemical analysis of platelet-derived growth factor receptor alpha in human hepatocellular carcinoma tissues revealed its correlation with postoperative recurrence, especially in patients without microvessel invasion. " 12/15/2005 - "Overexpression of platelet-derived growth factor receptor alpha was found only in the endothelium of highly metastatic hepatocellular carcinoma, which was confirmed by reverse transcription-PCR, real-time PCR, and immunohistochemistry. " 12/15/2005 - "Overexpression of platelet-derived growth factor receptor alpha in endothelial cells of hepatocellular carcinoma associated with high metastatic potential." 06/13/2017 - "Platelet-derived growth factor receptor α in hepatocellular carcinoma is a prognostic marker independent of underlying liver cirrhosis."

Related Drugs and Biologics

1.	Imatinib Mesylate (Gleevec)
2.	Phosphotransferases (Kinase)
3.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
4.	Tyrosine (L-Tyrosine)
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Platelet-Derived Growth Factor
7.	Tyrosine Kinase Inhibitors
8.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
9.	ErbB Receptors (EGF Receptor)
10.	Protein-Tyrosine Kinases (Tyrosine Kinase)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Radioimmunotherapy
4.	Artificial Respiration (Mechanical Ventilation)
5.	Radiotherapy