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Nerve Growth Factor Receptors (Neurotrophin Receptors)

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Cell surface receptors that bind NERVE GROWTH FACTOR; (NGF) and a NGF-related family of neurotrophic factors that includes neurotrophins, BRAIN-DERIVED NEUROTROPHIC FACTOR and CILIARY NEUROTROPHIC FACTOR.

Also Known As:

Neurotrophin Receptors; Receptors, Nerve Growth Factor; Receptors, Neurotrophic Factor; Neurotrophic Factor Receptors; Receptor, Neurotrophic Factor; NGF Receptors; Neurotrophic Factor Receptor; Receptors, NGF; Receptors, Neurotrophin

Networked: 235 relevant articles (2 outcomes, 22 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Aloe, Luigi: 5 articles (01/2015 - 06/2004)
2.	Davidson, Ben: 5 articles (02/2007 - 01/2004)
3.	Jin, Wook: 3 articles (03/2011 - 10/2007)
4.	Lazarovici, Philip: 3 articles (01/2007 - 01/2004)
5.	Reich, Reuven: 3 articles (02/2006 - 01/2004)
6.	Oderfeld-Nowak, B: 3 articles (10/2003 - 08/2001)
7.	Zaremba, M: 3 articles (10/2003 - 08/2001)
8.	Mahalingam, Meera: 2 articles (07/2015 - 05/2015)
9.	Frydenlund, Noah: 2 articles (07/2015 - 05/2015)
10.	Fournier, Michelle: 2 articles (02/2015 - 03/2014)

Related Diseases

1.	Spinal Cord Injuries (Spinal Cord Injury) 10/01/2000 - "Although numerous studies have examined the effects of neurotrophin treatment following spinal cord injury, few have examined the changes that occur in the neurotrophin receptors following either such damage or neurotrophin treatment. " 05/15/2014 - "We found an increased content of nerve growth factor and enhanced expression of nerve growth factor receptor in the spinal cord 24 hours after a single intranasal administration of nerve growth factor in healthy rats, while daily treatment for 3 weeks in a model of spinal cord injury improved the deficits in locomotor behaviour and increased spinal content of both nerve growth factor and nerve growth factor receptors. "
2.	Neuralgia (Stump Neuralgia) 01/01/2010 - "NGF administration reverses the neuro-glial morphomolecular changes occurring in neuropathic animals paralleled by alterations in neurotrophin receptors ratio, and suggest that NGF is effective in restoring homeostatic conditions in the spinal cord and maintaining analgesia in neuropathic pain." 01/01/2010 - "Intrathecal NGF administration reduces reactive astrocytosis and changes neurotrophin receptors expression pattern in a rat model of neuropathic pain."
3.	Neoplasms (Cancer) 06/01/2001 - "In the present study, we have assayed the expression of NGF receptors (NGFRs: TrkA and p75) mRNAs in 363 human primary breast cancers, using real-time quantitative reverse transcription-PCR. " 01/01/2013 - "We previously identified SALL2 as a novel interacting protein of neurotrophin receptors and showed that it plays a role in neuronal function, which does not necessarily explain why or how SALL2 is deregulated in cancer. " 12/06/2007 - "Growing evidence suggests that overexpression of TrkC, a member of the Trk family of neurotrophin receptors, could drive tumorigenesis, invasion and metastatic capability in cancer cells. " 10/01/2005 - "The expression of neurotrophin receptors (Trk-A, Trk-B, Trk-C and p75(NTR)) in thymic epithelial tumors was evaluated in 99 consecutive patients based on immunohistochemical staining. " 10/01/2005 - "Therefore, we analyzed the expression of neurotrophin receptors in surgically resected thymic epithelial tumors and evaluated their clinical relevance. "
4.	Carcinoma (Carcinomatosis) 01/01/2007 - "NGF receptors probably signal via MAPK-independent pathways in ovarian carcinoma." 01/01/2004 - "Altered expression and activation of the nerve growth factor receptors TrkA and p75 provide the first evidence of tumor progression to effusion in breast carcinoma." 11/01/2001 - "Expression levels of the nerve growth factor receptors TrkA and p75 in effusions and solid tumors of serous ovarian carcinoma patients." 09/01/2007 - "In vitro and in vivo effects of bicalutamide on the expression of TrkA and P75 neurotrophin receptors in prostate carcinoma." 01/01/1992 - "gamma IFN effectively stimulated the expression of NGF receptors in two colorectal carcinoma cell lines, but inhibited the expression in melanoma and breast carcinoma cells. "
5.	Prostatic Neoplasms (Prostate Cancer) 04/01/2008 - "The aim of this study was to focus on the localization and distribution of the immuno-reactivity for neurotrophins (NTs) and neurotrophin receptors (NTRs) in normal, hyperplastic and prostate cancer cells, obtained from 40 subjects. " 05/01/2010 - "The neurotrophin receptors TrkA (NGF receptor) and TrkC (NT-3 receptor) have been shown to be important in staging disease and predicting progression and drug response for various neoplasias such as neuroblastoma, medulloblastoma and prostate cancer. " 09/01/1999 - "To analyse the occurrence and cell distribution of p75(LNGFR) and Trk neurotrophin receptors in normal prostate, benign prostatic hypertrophy (BPH) and prostate carcinoma, and to determine the effect of androgen suppression on the expression of these proteins in prostate cancer samples. " 11/01/2005 - "In the present study we investigate the effects of GnRH analogs (leuprolide and cetrorelix) on the expression of TrkA and p75 neurotrophin receptors in primary cultures of human prostate cancer cells. "

Related Drugs and Biologics

1.	Nerve Growth Factor (NGF)
2.	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)
3.	Nerve Growth Factors (Neurotrophins)
4.	Messenger RNA (mRNA)
5.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
6.	Ligands
7.	Glial Cell Line-Derived Neurotrophic Factor (GDNF)
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9.	trkA Receptor
10.	Retinaldehyde (Retinal)

Related Therapies and Procedures

1.	Analgesia
2.	Intranasal Administration
3.	Lasers (Laser)