Laminin Receptors

Glycoprotein molecules on the surface of cells that react with or bind to laminin whose function allows the binding of epithelial cells to the basement membrane. The molecular weight of this high-affinity receptor is 67 kD.

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Networked: 415 relevant articles (3 outcomes, 47 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tachibana, Hirofumi: 13 articles (10/2015 - 04/2004)
2.	Weiss, Stefan F T: 11 articles (05/2015 - 01/2009)
3.	Yamada, Koji: 11 articles (11/2014 - 04/2004)
4.	Weiss, Stefan: 10 articles (05/2009 - 02/2003)
5.	Kumazoe, Motofumi: 7 articles (10/2015 - 01/2010)
6.	Tsukamoto, Shuntaro: 7 articles (10/2015 - 01/2012)
7.	Da Costa Dias, Bianca: 7 articles (05/2015 - 01/2011)
8.	Reusch, Uwe: 7 articles (01/2015 - 01/2008)
9.	Little, Melvyn: 7 articles (01/2015 - 01/2008)
10.	Knackmuss, Stefan: 7 articles (01/2015 - 01/2008)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2010 - "Our previous studies indicated that the Sindbis viral vectors target tumor cells by the laminin receptor. " 11/01/1997 - "Based on clinical data, which clearly demonstrate the importance of the receptor in tumor progression, studies were conducted to define the structure, expression, and function of this laminin receptor as a step toward developing therapeutic strategies that target this molecule. " 04/15/1989 - "Previous studies have identified a relationship between the presence of cell surface laminin receptors on murine tumor cells and sensitivity to killing by natural killer (NK) cells. " 01/01/2015 - "A high expression level of the 37kDa/67kDa laminin receptor (LRP/LR) is one characteristic of cancer cells. " 04/01/2014 - "37-kDa laminin receptor precursor (37LRP) has a crucial role in migration of some human cancers. "
2.	Neoplasm Metastasis (Metastasis) 07/29/2005 - "Recently, we have demonstrated that the anticancer activity of EGCG is mediated by the metastasis-associated 67kDa laminin receptor (67LR). " 10/24/2002 - "p53-dependent downregulation of metastasis-associated laminin receptor." 01/01/1999 - "The invasive phenotype of the immortalized cells was also reflected by the consistent expression of several metastasis-associated adhesion molecules, including alpha5 (eight of nine), alpha6 (five of nine), alphaV (nine of nine), beta1 (nine of nine), and beta3 (nine of nine) integrin subunits and the Mr 67,000 laminin receptor (seven of nine). " 12/01/1998 - "Laminin receptors are involved in cell-extracellular matrix interactions in malignant cells that show invasion and metastasis. " 03/01/1998 - "Furthermore, since high laminin receptor expression correlates with occurrence of metastases, it could become a useful prognostic marker."
3.	Prostatic Neoplasms (Prostate Cancer) 10/01/2011 - "Macrophage-dependent cleavage of the laminin receptor α6β1 in prostate cancer." 08/20/1997 - "Independent prognostic value of the 67-kd laminin receptor in human prostate cancer." 11/01/2001 - "Detection of the 67-kD laminin receptor in prostate cancer biopsies as a predictor of recurrence after radical prostatectomy." 07/31/2012 - "Laminin receptor specific therapeutic gold nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancer." 04/01/2004 - "During human prostate cancer progression, the integrin alpha6beta1 (laminin receptor) is expressed on the cancer cell surface during invasion and in lymph node metastases. "
4.	Necrosis 03/01/1990 - "Use of the information on laminin receptor expression, PR concentration, tumor size, lymphocytic infiltrate, and tumor necrosis improved significantly the prediction of the risk of recurrence. " 10/01/1994 - "Eight different prognostic factors, including menopausal status, tumour size, grading, lymphatic invasion, desmoplasia, necrosis, c-erbB-2 and laminin receptor expression, were evaluated retrospectively on a large series of primary breast carcinoma patients. " 01/01/1998 - "Cell death induced in lymphocytes expressing the elastin-laminin receptor by excess agonists: necrosis and apoptosis."
5.	Carcinoma (Carcinomatosis) 10/01/2001 - "Although the involvement of alpha 6 beta 4, an integrin laminin receptor, in hemidesmosome organization has dominated the study of this integrin, recent studies are revealing novel functions for alpha 6 beta 4 in the migration of epithelial and carcinoma cells. " 01/01/2009 - "67-kDa laminin receptor in human bile duct carcinoma." 07/01/2001 - "Integrin laminin receptors and breast carcinoma progression." 07/01/2000 - "Biologic characteristics of primary carcinomas were investigated by immunohistochemistry, and four pathologic and biologic parameters (size, grading, laminin receptor, and c-erbB-2 receptor) were analyzed to determine a prognostic score. " 08/01/1999 - "Sequences homologous to the mouse mammary tumor virus env gene in human breast carcinoma correlate with overexpression of laminin receptor."

Related Drugs and Biologics

1.	Micelles
2.	Etoposide (VP 16)
3.	Gold
4.	Laminin (Merosin)
5.	Carrier Proteins (Binding Protein)
6.	Laminin Receptors
7.	Collagen
8.	Monoclonal Antibodies
9.	Complementary DNA (cDNA)
10.	Peptides

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Endarterectomy (Thromboendarterectomy)
3.	Lasers (Laser)
4.	Gastrectomy
5.	Nanospheres