kappa Opioid Receptors (kappa Opioid Receptor)

A class of opioid receptors recognized by its pharmacological profile. Kappa opioid receptors bind dynorphins with a higher affinity than endorphins which are themselves preferred to enkephalins.

Also Known As:

Networked: 790 relevant articles (37 outcomes, 103 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kreek, Mary Jeanne: 11 articles (01/2022 - 12/2004)
2.	Porreca, Frank: 9 articles (04/2022 - 12/2016)
3.	Prisinzano, Thomas E: 9 articles (01/2022 - 03/2009)
4.	Navratilova, Edita: 8 articles (04/2022 - 07/2017)
5.	Xia, Qiang: 8 articles (08/2010 - 05/2004)
6.	Huang, Yiyun: 7 articles (01/2022 - 03/2005)
7.	Maslov, L N: 7 articles (01/2021 - 01/2001)
8.	Wong, Tak Ming: 7 articles (02/2012 - 04/2003)
9.	Nakao, Kaoru: 7 articles (11/2010 - 04/2004)
10.	Wong, T M: 7 articles (02/2007 - 08/2000)

Related Diseases

1.	Pain (Aches) 11/29/2016 - "Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and relieving pain. " 01/01/2024 - "Finally blockade on the kappa opioid receptor in the NAc confirmed its role in pain-induced anxiety-like behaviour in female rats. " 01/01/2024 - "Sex-dependent effect of inflammatory pain on negative affective states is prevented by kappa opioid receptors blockade in the nucleus accumbens shell." 01/01/2022 - "Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit." 01/01/2022 - "Here, we analyse the impact of pain on alcohol relapse and the role of kappa opioid receptor (KOR) activation in mediating these pain-induced effects because KORs play an important role in pain-driven negative affect and AUD. "
2.	Pruritus (Itching) 10/01/2020 - "This study was undertaken to analyse the expression of mu- and kappa-opioid receptors in the skin of HD patients with and without uraemic pruritus. " 09/01/2012 - "Studies suggest that pruritus may arise from an imbalance of the mu- and kappa-opioid receptor system activity in either the skin or the central nervous system. " 05/02/2022 - "Novel Kappa-Opioid Receptor Agonist for the Treatment of Cholestatic Pruritus: Systematic Review." 10/01/2020 - "Moreover, there was a significant negative correlation between intensity of pruritus and expression of kappa-opioid receptors (r = -0.63, P = 0.002). " 12/01/2015 - "The kappa opioid receptor (KOR) is involved in mediating pruritus; agonists targeting this receptor have been used to treat chronic intractable itch. "
3.	Substance-Related Disorders (Drug Abuse) 01/02/2004 - "The improved synthetic method-the overall yield was increased about 3-fold-combined with the practical methodology to determine optical purity will considerably facilitate the employment of these enantiomers as pharmacological tools for examination of the kappa-opioid receptor system, as well as their evaluation as drug abuse treatment agents. " 01/01/2023 - "Selective inhibition of kappa opioid receptors (KORs) is highly anticipated as a pharmacotherapeutic intervention for substance use disorders and depression. " 01/01/2020 - "The Rise and Fall of Kappa-Opioid Receptors in Drug Abuse Research." 01/01/2018 - "The affinity of MGM-9 on kappa-opioid receptor could potentially limit the effects of drug dependence. " 10/01/2016 - "Kappa-opioid receptor (KOR) antagonists are currently being considered for the treatment of a variety of neuropsychiatric conditions, including depressive, anxiety, and substance abuse disorders. "
4.	Visceral Pain 05/01/1998 - "The present results provide further evidence that kappa-opioid receptor agonists significantly attenuate visceral nociception and, in conjunction with other information, suggest that a peripherally restricted kappa-opioid receptor agonist would be therapeutically effective in relieving visceral pain." 05/01/1998 - "The objective of this study was to evaluate the effects of kappa-opioid receptor agonists on pressor and visceromotor responses to colorectal distension in awake, unrestrained rats, a model of visceral pain. " 03/01/2009 - "Kappa-opioid receptors are located on visceral pain fibres. " 08/01/2004 - "Modulation of the function of kappa-receptors may be a novel approach to control visceral pain in functional gut disorders. " 11/01/2000 - "All pelvic nerve fibers innervating the descending colon can be sensitized and contribute to visceral pain; their responses are modulated by kappa-opioid receptor agonists acting in the periphery."
5.	Chronic Pain 03/23/2021 - "Kratom is an unregulated kappa-opioid receptor agonist available for order on the internet that is used as a remedy for chronic pain. " 01/01/2019 - "Kappa opioid receptor (KOR) agonists show promise in ameliorating disorders, such as addiction and chronic pain, but are limited by dysphoric and aversive side effects. " 09/19/2023 - "ACC kappa opioid receptor activation therefore diminishes descending control of nociception both in naïve animals and as an adaptive response to chronic pain likely by enhancing net descending facilitation. " 06/01/2019 - "Targeting Peripheral Kappa Opioid Receptors for the Treatment of Chronic Pain: Review Article." 01/01/2019 - "Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain."

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Opioid Analgesics (Opioids)
3.	kappa Opioid Receptors (kappa Opioid Receptor)
4.	TRK 820
5.	Dopamine (Intropin)
6.	Dynorphins (Dynorphin)
7.	(trans)-Isomer 3,4- Dichloro- N- methyl- N- (2- (1- pyrrolidinyl)- cyclohexyl)- benzeneacetamide
8.	enadoline
9.	Capsaicin (Zostrix)
10.	nalmefene (Revex)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Intravenous Administration
3.	Therapeutics
4.	Analgesia
5.	Renal Dialysis (Hemodialysis)