Interleukin-1 Receptors (Interleukin 1 Receptor)

Cell surface receptors that are specific for INTERLEUKIN-1. Included under this heading are signaling receptors, non-signaling receptors and accessory proteins required for receptor signaling. Signaling from interleukin-1 receptors occurs via interaction with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88.

Also Known As:

Networked: 432 relevant articles (18 outcomes, 54 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dinarello, Charles A: 4 articles (01/2013 - 10/2003)
2.	Agartz, Ingrid: 3 articles (02/2015 - 12/2011)
3.	Andreassen, Ole A: 3 articles (02/2015 - 12/2011)
4.	Ueland, Thor: 3 articles (02/2015 - 12/2011)
5.	Dieset, Ingrid: 3 articles (02/2015 - 12/2011)
6.	Hope, Sigrun: 3 articles (02/2015 - 12/2011)
7.	Aukrust, Pål: 3 articles (02/2015 - 12/2011)
8.	Corr, Maripat: 3 articles (05/2013 - 02/2003)
9.	Punnonen, Kari: 3 articles (03/2012 - 10/2003)
10.	Zaleska, Marzanna: 3 articles (12/2007 - 09/2003)

Related Diseases

1.	Rheumatoid Arthritis 08/01/2007 - "Ex vivo interleukin 1 receptor antagonist production on lipopolysaccharide stimulation is associated with rheumatoid arthritis and with joint damage." 11/01/2003 - "Two clinical trails using ex vivo retrovirus mediated delivery of interleukin -1 receptor antagonist gene for rheumatoid arthritis has begun in USA and Germany. " 12/01/2002 - "Interleukin -1 receptor antagonist ( IL-1Ra ) is a new option among biotherapies against rheumatoid arthritis ( RA ). " 01/01/2002 - "[Interleukin-1 receptor antagonists in the treatment rheumatoid arthritis]." 01/17/2000 - "Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice."
2.	Sepsis (Septicemia) 01/01/2015 - "Many studies have focused on the relationship between interleukin 1 receptor antagonist (IL1RN) gene 86-bp VNTR polymorphism and sepsis, but the results remain inconsistent. " 01/01/2015 - "Association between interleukin 1 receptor antagonist gene 86-bp VNTR polymorphism and sepsis: a meta-analysis." 10/01/2013 - "Role of interleukin 1 receptor like 1 (ST2) in gram-negative and gram-positive sepsis in mice." 02/01/1998 - "Compared with the survivors, the interleukin-1 receptor antagonist was markedly elevated in all nonsurvivors after 6 h of sepsis (p < .05). " 09/29/1998 - "Anterior hypothalamic interleukin-1 receptors are involved in mediation of fever during bacterial sepsis in rats."
3.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 06/05/1999 - "Previous studies have shown an association between the allele 2 of IL1RN, the gene that encodes for the interleukin 1 receptor antagonist (IL-1ra), and the inflammatory bowel disease. " 01/01/1994 - "Colonic mucosal interleukin 1 receptor antagonist in inflammatory bowel disease." 01/01/1994 - "To clarify the role of the interleukin 1 receptor antagonist (IL-1ra) in patients with inflammatory bowel disease (IBD), we assessed the local IL-1ra concentrations in tissue homogenates using a specific enzyme-linked immunosorbent assay and examined the immunohistochemical localization using a monoclonal antibody against IL-1ra. " 08/01/2010 - "Commensal bacteria can activate signaling by the Toll-like and interleukin-1 receptors (TLR and IL-1R) to mediate pathogenesis of inflammatory bowel diseases and colitis-associated cancer. " 06/01/2002 - "In ulcerative colitis tissue and non-inflamed non-inflammatory bowel disease control tissue, no significant increase in interleukin 1 receptor antagonist/interleukin-1beta ratio was seen after incubation with elemental diet, casein and whey. "
4.	Arthritis (Polyarthritis) 10/01/1998 - "[Treatment of chronic polyarthritis with a human recombinant interleukin 1 receptor antagonist]." 04/01/2012 - "Interleukin 1 receptor antagonist (IL-1Ra)-deficient BALB/c mice develop spontaneous arthritis resembling human rheumatoid arthritis. " 02/01/2012 - "Articular inflammation is controlled by myeloid cell-derived interleukin 1 receptor antagonist during the acute phase of arthritis in mice." 02/01/2006 - "To test a hypothesis of compartmentalized pathogenesis of different types of arthritis, namely inflammatory arthritis (IA) and osteoarthritis (OA), synovial and cartilage biopsies were examined for the expression of TNF and IL-1 receptors. " 04/01/2005 - "Preliminary results of safety and efficacy of the interleukin 1 receptor antagonist anakinra in patients with severe lupus arthritis."
5.	Experimental Arthritis 11/01/1996 - "The results showed that (a) both IL-1 receptors (IL-1RI and -II) mRNA were expressed by osteoclasts in all tissue sections of normal tibiae; (b) at the stage of the adjuvant arthritis studied, the IL-1RI mRNA was the most predominant message in osteoclasts present in the area with serious cartilage and bone destruction, whereas the expression level of IL-1RII mRNA in these osteoclasts was weak; and (c) both IL-1RI and -II mRNA were expressed by osteoblasts, as well as by osteocytes localized in the osteoid. " 11/01/1996 - "Osteoclasts in normal and adjuvant arthritis bone tissues express the mRNA for both type I and II interleukin-1 receptors." 10/01/1992 - "The ability of IL-1Ra to block IL-1 receptors without agonist activities has reduced the severity of diseases such as septic shock, lethal sepsis, inflammatory bowel disease, experimental arthritis, and the spontaneous proliferation of human leukemic cells." 04/15/1991 - "The ability of this IL-1ra to block the triggering of IL-1 receptors in animals without agonist effects has reduced the severity of diseases such as hemodynamic shock, lethal sepsis, inflammatory bowel disease, experimental arthritis, and the spontaneous proliferation of human leukemic cells."

Related Drugs and Biologics

1.	Interleukin 1 Receptor Antagonist Protein (Anakinra)
2.	Interleukin-10 (Interleukin 10)
3.	Interleukins
4.	Interleukin-1 (Interleukin 1)
5.	Interleukin-6 (Interleukin 6)
6.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
7.	Methotrexate (Mexate)
8.	C-Reactive Protein
9.	Interleukin-4 (Interleukin 4)
10.	Interleukin-8 (Interleukin 8)

Related Therapies and Procedures

1.	Intravitreal Injections
2.	Off-Label Use
3.	Biological Therapy
4.	Transplants (Transplant)
5.	Injections