Fibronectin Receptors

Specific cell surface receptors which bind to FIBRONECTINS. Studies have shown that these receptors function in certain types of adhesive contact as well as playing a major role in matrix assembly. These receptors include the traditional fibronectin receptor, also called INTEGRIN ALPHA5BETA1 and several other integrins.

Also Known As:

Networked: 37 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Livant, Donna L: 2 articles (10/2011 - 12/2004)
2.	Zeng, Zhao-Zhu: 2 articles (10/2011 - 12/2004)
3.	Arciola, Carla Renata: 1 article (11/2019)
4.	Pietrocola, Giampiero: 1 article (11/2019)
5.	Speziale, Pietro: 1 article (11/2019)
6.	Balcioglu, Hayri E: 1 article (04/2015)
7.	Danen, Erik H J: 1 article (04/2015)
8.	Donato, Dominique M: 1 article (04/2015)
9.	Schmidt, Thomas: 1 article (04/2015)
10.	van Hoorn, Hedde: 1 article (04/2015)

Related Diseases

1.	Neoplasms (Cancer) 02/27/1981 - "After metastasis, fibronectin receptors are apparently restored in those secondary tumor foci that become established. " 04/01/2015 - "During development, angiogenesis, wound healing and cancer progression, the relative abundance of fibronectin receptors, including integrins α5β1 and αvβ3, changes, thus altering the integrin composition of cell-matrix adhesions. " 08/15/2003 - "The alpha(5)beta(1) integrin is one of the major fibronectin receptors which plays an essential role in the adhesion of normal and tumor cells to extracellular matrix. " 11/01/1992 - "Similarly, altered expression pattern of many other adhesion molecules such as upregulated expression of the laminin receptors and depressed expression of fibronectin receptors (alpha 5 beta 1) appears to be involved in tumor cell invasion into the subendothelial matrix. " 03/05/2010 - "The results using other hematopoietic tumor cell lines expressing different levels of fibronectin receptors (VLA-4 and VLA-5) showed that potentiated and sustained adhesion to fibronectin via VLA-4 causally induces apoptosis also in various types of hematopoietic tumor cells in addition to Ramos cells. "
2.	Glioma (Gliomas) 03/01/1993 - "Comparison of the model with data at 37 degrees C suggests that while cytoskeletal cross-linking and clustering of fibronectin receptors significantly increases adhesion strength, specific glioma cell-substratum attachment sites possess little mechanical rigidity and detach through a peeling mechanism, consistent with the view that these sites of < or = 15 nm cell-substrate separation are precursors to fully formed, elastically rigid focal contacts." 10/03/1994 - "Localization of vitronectin- and fibronectin-receptors on cultured human glioma cells." 03/01/1993 - "Our model successfully predicts the observed detachment forces at 4 degrees C and yields values for the number of fibronectin receptors per glioma cell and the density of cytoskeletal connection molecules (talin) involved in receptor clusters which are consistent with measurements for other cell types. " 06/19/1992 - "All cell lines tested expressed alpha V beta 1. Human neuroblastoma cells, the majority of which are N-type cells with very low alpha 5 beta 1 expression, are also contrasted with other childhood cancer cells (rhabdomyosarcoma, Ewing's sarcoma, and glioma), all of which expressed high levels of alpha 5 beta 1. The characteristic expression of integrin fibronectin receptors may account for the clinically unique tumor behavior, and the immunohistochemical staining for integrins may become a useful alternative to conventional histology in differential diagnosis and a marker for prognosis in neuroblastoma." 11/01/1998 - "Four glioma cells derived from GB whose tumor cells did not positively stain for fibronectin receptors migrated much less extensively to fibronectin than other glioma cells whose tissues showed positive staining for the fibronectin receptor. "
3.	Wounds and Injuries (Trauma) 06/01/1990 - "Fibronectin receptors were expressed by fibroblasts just prior to wound contraction." 01/01/1990 - "Neither actin bundles nor fibronectin receptors were observed in 5-d wound fibroblasts. " 06/01/1990 - "Day-7 wound fibroblasts expressed fibronectin receptors, contained peripheral cytoplasmic actin bundles consistent with a contractile fibroblast phenotype, and were coaligned across the wound in parallel array with interconnecting fibronectin fibrils. " 01/01/1990 - "These cells expressed fibronectin receptors, were embedded in a fibronectin matrix that appeared to connect fibroblasts to the matrix and to each other, and were coaligned across the wound. " 07/01/1996 - "Although alpha 5 beta 1 integrin, a fibronectin receptor, is expressed by human epidermis during re-epithelialization of excisional and incisional wounds, the spatial and temporal patterns of vitronectin, tenascin, and other fibronectin receptors are less clear. "
4.	Infections 11/26/2019 - "This review updates the current understanding of fibronectin receptors of several microorganisms with emphasis on their biochemical and structural properties and the role they can play in the onset and progression of host infection diseases. " 12/01/1990 - "Epidemiologic studies show a correlation between expression of fibronectin receptors and development of invasive infections. " 01/01/1985 - "The damage to the cell membrane during HSV infection shows certain analogous mechanisms with events induced by Cytochalasin B and might be explained by the loss of hypothetical fibronectin receptors."
5.	Melanoma (Melanoma, Malignant) 03/26/2008 - "The expression of alpha(3)beta(1), alpha(4)beta(1), alpha(5)beta(1), and alpha(v)beta(3) integrins, acting as fibronectin receptors, differed between the tested cell lines, and no distinct pattern distinguished uveal melanoma from cutaneous melanoma except for high expression of alpha(4)beta(1) integrin on both FM55P and IGR-39 cells. " 06/17/2009 - "M2 melanoma cells null for filamin A do not alter their adherent area in response to increased substrate stiffness when they link to the substrate only through collagen receptors, but change adherent area normally when bound through fibronectin receptors. "

Related Drugs and Biologics

1.	Integrins
2.	Fibronectins (Fibronectin)
3.	Vitronectin
4.	Integrin alpha5beta1
5.	Integrin alpha4beta1 (VLA-4)
6.	Laminin Receptors
7.	Phorbol Esters
8.	Filamins
9.	Integrin alphaVbeta3
10.	Collagen Receptors

Related Therapies and Procedures

1.	Antibiotic Prophylaxis