Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)

Specific molecular sites or structures on cell membranes that react with FIBROBLAST GROWTH FACTORS (both the basic and acidic forms), their analogs, or their antagonists to elicit or to inhibit the specific response of the cell to these factors. These receptors frequently possess tyrosine kinase activity.

Also Known As:

Networked: 814 relevant articles (12 outcomes, 69 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ornitz, David M: 11 articles (09/2013 - 04/2002)
2.	Marian, Brigitte: 9 articles (12/2015 - 10/2008)
3.	Grusch, Michael: 9 articles (12/2015 - 10/2008)
4.	Berger, Walter: 9 articles (12/2015 - 10/2008)
5.	Holzmann, Klaus: 8 articles (12/2015 - 10/2008)
6.	Ezzat, Shereen: 8 articles (11/2012 - 03/2005)
7.	Asa, Sylvia L: 8 articles (11/2012 - 03/2005)
8.	Grasl-Kraupp, Bettina: 7 articles (12/2015 - 10/2008)
9.	Mohammadi, Moosa: 7 articles (11/2014 - 01/2004)
10.	Hynes, Nancy E: 7 articles (04/2013 - 04/2004)

Related Diseases

1.	Neoplasms (Cancer) 06/01/1999 - "Screening a rat embryo cDNA library with bFGF in the yeast two hybrid system identified a short variant of FGF receptor 1, found most frequently in embryonal and tumor cells and which possesses affinity toward bFGF that is significantly greater than that of the more abundant, full-length receptor. " 11/01/2006 - "The PEI-CR16/pDNA polyplexes showed significantly greater transgene activity than PEI/pDNA in FGF receptors positive tumor cells in vitro and in vivo gene transfer, while no difference was observed in FGF receptors negative tumor cells. " 10/20/2015 - "Phase I Dose-Escalation Study of JNJ-42756493, an Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients With Advanced Solid Tumors." 03/15/1993 - "In studies aimed to determine whether FGF receptors contribute to the development of human tumors, we screened RNAs prepared from cell lines derived from a variety of solid tumors. " 11/01/2015 - "The important role of fibroblast growth factor receptors (FGFRs) has been widely recognized in many types of cancers, but the association between FGFR polymorphisms and HCC carcinogenesis has been rarely reported. "
2.	Schizophrenia (Dementia Praecox) 11/01/2010 - "A large association study by O'Donovan et al recently suggested that genetic variation in fibroblast growth factor receptor (FGFR) 2 increases the risk for developing schizophrenia. " 10/01/2013 - "Mutant mice for FGF receptor 1 show schizophrenia-like behaviors that are related to general loss of neurons and postnatal glia dysfunction. " 09/01/2009 - "The current study examines a transgenic th(tk-)/th(tk-) mouse model with FGF receptor signaling disruption targeted to dopamine (DA) neurons, resulting in neurodevelopmental, anatomical, and biochemical alterations similar to those observed in human schizophrenia. " 02/01/2013 - "Our research suggests that altered FGF receptor signaling plays a central role in the developmental abnormalities underlying schizophrenia and that nicotinic agonists are an effective class of compounds for the treatment of schizophrenia." 06/01/2006 - "Fibroblast growth factor receptor signaling affects development and function of dopamine neurons - inhibition results in a schizophrenia-like syndrome in transgenic mice."
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 03/01/2013 - "Role of FGF receptors as an emerging therapeutic target in lung squamous cell carcinoma." 10/01/2012 - "Rationale for treatment of metastatic squamous cell carcinoma of the lung using fibroblast growth factor receptor inhibitors." 08/01/2011 - "Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells." 06/01/1998 - "Fibroblast growth factor receptor expression reflects cellular differentiation in human oral squamous carcinoma cell lines." 03/01/1996 - "We have screened normal oral mucosa and oral squamous cell carcinoma (SCC) for expression of bFGF by immunohistology and northern analysis and used RT-PCR to look for transcripts for KGF and the high-affinity FGF receptors FGFR1 and FGFR2. "
4.	Stomach Neoplasms (Stomach Cancer) 12/01/2015 - "To assess the efficacy of targeting fibroblast growth factor receptor (FGFR) with the pan-FGFR inhibitor BGJ398 in a gastric cancer (GC) model. " 01/01/2016 - "Up to 10 % of primary gastric cancers are characterized by FGFR2 amplification, and fibroblast growth factor receptor (FGFR) inhibitors may represent therapeutic agents for patients with these malignancies. " 12/01/2015 - "Targeting Fibroblast Growth Factor Receptor (FGFR) with BGJ398 in a Gastric Cancer Model." 01/01/2015 - "Therapeutic targeting of fibroblast growth factor receptors in gastric cancer." 11/01/2013 - "FGF receptor 2 (FGFR2) is preferentially amplified and overexpressed in the diffuse type of gastric cancer. "
5.	Pituitary Neoplasms (Pituitary Adenoma) 05/01/2009 - "Based on prior work showing that human pituitary tumors overexpress epidermal and fibroblast growth factor receptors, we hypothesized that downstream components of growth factor signaling pathways may also be dysregulated. " 07/01/2001 - "Aberrant expression of members of the FGF family, an FGF antisense gene and FGF receptors have all been described in pituitary adenomas. " 04/01/1997 - "Altered expression of fibroblast growth factor receptors in human pituitary adenomas." 04/25/1994 - "Immunohistochemical study for basic fibroblast growth factor and fibroblast growth factor receptor I in pituitary adenomas." 02/01/1997 - "The effects of estradiol (E2) on cell growth and the expression of fibroblast growth factor receptor (FGFR) were investigated in a cultured rat anterior pituitary cell line (MtT/Se) established from an E2-induced mammotropic pituitary tumor. "

Related Drugs and Biologics

1.	Fibroblast Growth Factors (Fibroblast Growth Factor)
2.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
3.	tebufenozide (Mimic)
4.	Matrix Metalloproteinases
5.	Antipsychotic Agents (Antipsychotics)
6.	Serotonin Antagonists
7.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
8.	Cuprizone
9.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Transplantation (Transplant Recipients)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Drug Therapy (Chemotherapy)
5.	Immunotherapy