delta Opioid Receptors (delta Opioid Receptor)

A class of opioid receptors recognized by its pharmacological profile. Delta opioid receptors bind endorphins and enkephalins with approximately equal affinity and have less affinity for dynorphins.

Also Known As:

Networked: 585 relevant articles (13 outcomes, 63 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kieffer, Brigitte L: 12 articles (02/2015 - 02/2003)
2.	Xia, Ying: 9 articles (07/2012 - 07/2005)
3.	Balboni, Gianfranco: 8 articles (07/2012 - 12/2002)
4.	Maslov, L N: 8 articles (10/2006 - 09/2000)
5.	Matifas, Audrey: 6 articles (02/2015 - 02/2003)
6.	Salvadori, Severo: 6 articles (07/2012 - 12/2002)
7.	Maldonado, Rafael: 5 articles (02/2015 - 02/2003)
8.	Rice, Kenner C: 5 articles (04/2012 - 11/2002)
9.	Pol, Olga: 5 articles (09/2010 - 08/2003)
10.	Suzuki, T: 5 articles (02/2007 - 04/2000)

Related Diseases

1.	Pain (Aches) 01/01/2013 - "In contrast, animal models suggest that chronic pain is more effectively relieved by delta opioid receptor agonists. " 01/01/2013 - "However, recent studies have questioned this mechanism, which has resulted in some uncertainty as to whether delta opioid receptors are indeed upregulated in chronic pain states. " 01/01/2013 - "A number of studies have shown that chronic pain results in increased function of delta opioid receptors. " 10/01/2011 - "Preclinical data have confirmed that delta opioid receptor activation reduces persistent pain and improves negative emotional states; clinical trials have been initiated to assess the effectiveness of delta opioid agonists in chronic pain and depression. " 12/01/2008 - "This study examined the association between pressure pain sensitivity and various single nucleotide polymorphisms (SNPs) of human micro-, kappa-, and delta-opioid receptor (i.e. "
2.	Fibromyalgia (Fibrositis) 07/01/2007 - "Up-regulation of delta-opioid receptors and kappa-opioid receptors in the skin of fibromyalgia patients." 03/01/2011 - "Although there is no known cure for fibromyalgia, multidisciplinary team efforts using combined treatment approaches, including patient education, aerobic exercise, cognitive behavioral therapy, and pharmacologic therapies (serotonin norepinephrine reuptake inhibitors [e.g., duloxetine, milnacipran] and alpha 2-delta receptor ligands [e.g., pregabalin]) might improve symptoms as well as function in patients with fibromyalgia." 07/01/2010 - "Although there is no known cure for fibromyalgia, multidisciplinary team efforts using combined treatment approaches, including patient education, aerobic exercise, cognitive behavioral therapy, and pharmacologic therapies (serotonin norepinephrine reuptake inhibitors [eg, duloxetine, milnacipran] and alpha 2-delta receptor ligands [eg, pregabalin]) may improve symptoms as well as function of patients with fibromyalgia."
3.	Neuroblastoma 04/29/1999 - "The efficacy of different opioid agonists to induce acute desensitization of the human delta-opioid receptor-mediated inhibition of cAMP accumulation was investigated in the neuroblastoma cell line SK-N-BE, which endogenously expresses these receptors. " 06/19/2003 - "After transfection of the human wild type delta receptor (hdelta(wt)) into NG 108-15 rodent neuroblastoma-derived cells, HEK 293 human embryonic kidney cells and NIH 3T3 mouse fibroblasts, all these cell types produced hdelta(deltaICD3). " 06/19/2003 - "In addition to the established human delta opioid receptor SH-SY5Y neuroblastoma cells produce an atypical, shorter, form of this receptor which is predicted to lack the third intracellular domain. " 06/19/2003 - "A truncated delta opioid receptor, spontaneously produced in human but not rat neuroblastoma cells, interferes with signaling of the full-length receptor." 04/01/2000 - "Internalization, recycling, and resensitization of the human delta-opioid receptor (hDOR) were studied in the neuroblastoma cell line SK-N-BE, endogenously expressing this receptor. "
4.	Neoplasms (Cancer) 07/31/2007 - "In knockout experiments in mice, we show that the targeted removal of a hub node (peroxisome proliferative-activated receptor delta) of the angiogenic network markedly impairs angiogenesis and tumor growth. " 06/02/2011 - "Spinal activation of delta opioid receptors alleviates cancer-related bone pain." 07/31/2007 - "Further, in tumor patients, we show that peroxisome proliferative-activated receptor delta expression levels are correlated with advanced pathological tumor stage, increased risk for tumor recurrence, and distant metastasis. " 05/01/2006 - "Cancer-related bone pain is attenuated by a systemically available delta-opioid receptor agonist." 01/01/2005 - "In addition, as some conditions associated with cholestasis and bile ductular proliferation can be complicated by malignancy, the expression of the delta opioid receptor in malignant tumors of the biliary tree merits research."
5.	Hyperalgesia 11/24/2010 - "Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat." 01/14/2009 - "Here we report that the peripheral delta opioid receptor system also requires PKC-dependent priming to inhibit prostaglandin E(2) (PGE(2))-induced thermal allodynia in the rat. " 03/15/2008 - "Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia." 06/18/2004 - "These data indicate that peripheral kappa- and delta-opioid receptors are involved in the antinociceptive effect of Crotalus durissus terrificus on prostaglandin E(2)-induced hyperalgesia. " 01/01/1998 - "OFQ induces hyperalgesia and antagonizes opioid analgesia mediated by mu- and delta-receptors in the brain and by mu- and kappa- but not delta-receptors in the spinal cord of rats."

Related Drugs and Biologics

1.	Ligands
2.	Serotonin (5 Hydroxytryptamine)
3.	Norepinephrine (Noradrenaline)
4.	pregabalin (Lyrica)
5.	duloxetine (Cymbalta)
6.	milnacipran (Ixel)
7.	mu Opioid Receptors (mu Opioid Receptor)
8.	Enkephalins
9.	Opioid Receptors (Opioid Receptor)
10.	D-Penicillamine (2,5)- Enkephalin

Related Therapies and Procedures

1.	Analgesia
2.	Cardiopulmonary Resuscitation (CPR)
3.	Pneumonectomy (Lung Volume Reduction)
4.	Aftercare (After-Treatment)
5.	Resuscitation