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Irritant Dermatitis

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A non-allergic contact dermatitis caused by prolonged exposure to irritants and not explained by delayed hypersensitivity mechanisms.

Also Known As:

Dermatitis, Irritant; Dermatitides, Irritant; Dermatitides, Primary Irritant; Irritant Dermatitides; Irritant Dermatitides, Primary; Irritant Dermatitis, Primary; Primary Irritant Dermatitides; Primary Irritant Dermatitis; Dermatitis, Primary Irritant

Networked: 136 relevant articles (5 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases
- Skin Diseases: 8226
  - Dermatitis: 5730
    - Contact Dermatitis: 5268
      - Irritant Dermatitis: 136
        Phototoxic Dermatitis: 1623
        Diaper Rash: 50
  - Eczematous Skin Diseases: 17
    - Contact Dermatitis: 5268
      - Irritant Dermatitis: 136
        Phototoxic Dermatitis: 1623
        Diaper Rash: 50

Related Diseases

1.	Skin Diseases
2.	Acne Vulgaris
3.	Melanosis (Freckles)
4.	Eczema
5.	Blister (Bulla)

Experts

1.	Harii, Kiyonori: 2 articles (08/2013 - 02/2003)
2.	Gallucci, Randle M: 2 articles (04/2013 - 09/2004)
3.	Maibach, Howard I: 2 articles (08/2012 - 11/2009)
4.	Matsumoto, Daisuke: 2 articles (08/2007 - 02/2003)
5.	Sato, Katsujiro: 2 articles (08/2007 - 02/2003)
6.	Yoshimura, Kotaro: 2 articles (08/2007 - 02/2003)
7.	Ly, F: 2 articles (12/2006 - 03/2003)
8.	Mahé, A: 2 articles (12/2006 - 03/2003)
9.	Beylot-Barry, M: 1 article (06/2015)
10.	Masson-Regnault, M: 1 article (06/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Irritant Dermatitis:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/1998 - "Treatment with corticosteroids is often effective for irritant dermatitis. " 11/01/2001 - "This study was designed to assess the efficacy of low- and medium-potency corticosteroids on irritant dermatitis. " 11/01/2001 - "Corticosteroids were found ineffective in treating the surfactant-induced irritant dermatitis when compared with the vehicle and with the untreated control. " 07/01/2011 - "By encouraging the patient to follow a regular rotation schedule for the patch, and using lipid-based emollients for irritant dermatitis and pre- and post-treatment topical corticosteroids for allergic dermatitis, cutaneous reactions can often be alleviated and patients can continue with their medication regimen. " 02/01/1996 - "Primary irritant dermatitis was regarded as the common cause but to investigate the place of contact allergy 50 patients were patch tested to a standard battery, medicaments, preservatives, corticosteroids and miscellaneous allergens. "
2.	Tretinoin (Retinoic Acid)FDA LinkGeneric 06/01/1975 - "The daily application of 0-3% retinoic acid to the back produced an acute irritant dermatitis which resolved to a near-normal clinical appearance within 40 days despite continued daily exposure. " 05/01/2006 - "The efficacy of tretinoin is well established in the treatment of acne and photoaged skin, however as a typical side effect of tretinoin treatment most patients develop a low-grade irritant dermatitis. " 02/01/2003 - "ROL can improve skin hyperpigmentation to a similar extent to tretinoin when used at high concentration, whereas it induces irritant dermatitis as well." 08/01/2007 - "Although combined use of tretinoin (all-trans-retinoic acid; atRA) and hydroquinone improves various hyperpigmented lesions, the pharmacologic instability of atRA and atRA-induced irritant dermatitis are difficult unsolved problems. " 02/01/2003 - "Although an aggressive use of tretinoin along with hydroquinone enables an efficient treatment of hyperpigmented skin lesions, irritant dermatitis remains to be solved. "
3.	SiliconesIBA 08/01/2013 - "RA/HQ sheets improved epidermal melanosis, as did the conventional bleaching method, but irritant dermatitis occurred less in patients treated using silicone sheets. "
4.	pimecrolimus (Elidel)FDA Link 09/01/2008 - "Pimecrolimus cream 1% provides a new potential option for treatment of irritant dermatitis of the periocular region, head and neck. " 09/01/2008 - "Twenty-seven patients with periocular irritant dermatitis (extending onto the face and neck in eight) were treated twice daily with pimecrolimus cream 1% for 7 d, followed by once-daily application for a further 7 d. " 09/01/2008 - "Treatment with pimecrolimus cream 1% clears irritant dermatitis of the periocular region, face and neck." 09/01/2008 - "Pimecrolimus cream 1%, a nonsteroid, cell-selective inhibitor of inflammatory-cytokine release, is effective in the treatment of inflammatory skin diseases, such as chronic irritant dermatitis of the hands, and thus offers a potential therapeutic option for this indication. "
5.	Detergents (Detergent)IBA 01/01/1999 - "In the human study, a dose-response relationship between the concentration of detergent used for the induction of irritant dermatitis and the ensuing increase in drug penetration across the skin could be demonstrated. " 01/01/2003 - "Irritant dermatitis to detergents in textiles." 08/01/1997 - "These late effects of detergents should be considered when studying irritant chemical interactions and in developing strategies for the management of occupational and other irritant dermatitis." 10/01/1996 - "Although the induction of acute irritant dermatitis by detergents has been studied extensively in recent years, our understanding of the cell biological events in the repair phase, and its relevance for the development of chronic irritant dermatitis is limited. " 06/01/1993 - "One important group of substances causing irritant dermatitis is detergents. "
6.	AntiperspirantsIBA 05/01/1992 - "However, the antiperspirants also increased (p less than 0.05) the incidence of irritant dermatitis. " 10/01/1995 - "This study investigated the influence of an antiperspirant with emollient additives on frequency and severity of friction blisters, hot spots, and irritant dermatitis. " 10/01/1995 - "The use of an antiperspirant with emollients reduces irritant dermatitis but does not reduce total foot-sweat accumulation, blister or hot spot incidence, or blister severity."
7.	Copper Sulfate (Sulfate, Copper)FDA Link 07/01/2013 - "In this phase III open labeled, multicenter, non-controlled, non-randomized trial, irritant dermatitis in children and adults either due to diaper rash, pityriasis alba and irritant dermatitis (eczema), perioral dermatitis, perleche or intertrigo were administered; repairing cream RV 2427 B containing a) 4 % zinc oxide, b) 2.5 % dry colloidal oat extract, (c) 0.5 % oat oil, (d) 0.2% copper sulfate, and (e) 0.1 % zinc sulfate to be applied twice-daily in the affected area. "
8.	Zinc Sulfate FDA Link 07/01/2013 - "In this phase III open labeled, multicenter, non-controlled, non-randomized trial, irritant dermatitis in children and adults either due to diaper rash, pityriasis alba and irritant dermatitis (eczema), perioral dermatitis, perleche or intertrigo were administered; repairing cream RV 2427 B containing a) 4 % zinc oxide, b) 2.5 % dry colloidal oat extract, (c) 0.5 % oat oil, (d) 0.2% copper sulfate, and (e) 0.1 % zinc sulfate to be applied twice-daily in the affected area. "
9.	Zinc Oxide FDA Link 07/01/2013 - "In this phase III open labeled, multicenter, non-controlled, non-randomized trial, irritant dermatitis in children and adults either due to diaper rash, pityriasis alba and irritant dermatitis (eczema), perioral dermatitis, perleche or intertrigo were administered; repairing cream RV 2427 B containing a) 4 % zinc oxide, b) 2.5 % dry colloidal oat extract, (c) 0.5 % oat oil, (d) 0.2% copper sulfate, and (e) 0.1 % zinc sulfate to be applied twice-daily in the affected area. "
10.	Metronidazole (Metric)FDA LinkGeneric 07/01/2008 - "Samples were collected in a study of the penetration of a metronidazole cream formulation (Flagyl 1%) applied to forearm skin in both areas with irritant dermatitis and normal skin. " 07/01/2008 - "Conversely, the concentration of metronidazole in tape-strip samples was significantly decreased in irritant dermatitis. " 07/01/2008 - "Microdialysis showed a significant threefold increase in metronidazole penetration in skin with irritant dermatitis compared with unmodified skin. " 07/01/2008 - "The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method."

Therapies and Procedures

1.	Skin Care 04/01/2008 - "Using this structured protocol, the cases of irritant dermatitis were also reported, and it is recommended that such a protocol is used as a standard to improve the reporting of adverse reactions to skin care products." 11/01/2006 - "Mycoses and irritant dermatitis are the main causes of DD in the elderly, and emollient skin care and topical antifungal treatment can be considered a first-line therapy for this indication."
2.	Ostomy 03/01/2010 - "Peristomal irritant dermatitis caused by skin contact with ostomy effluent is by far the most ordinary condition seen. " 01/01/2014 - "Although ostomy complications such as allergic contact and irritant dermatitis are common, psoriasis may be misdiagnosed. "
3.	Protective Gloves 11/01/2009 - "This underlines the unique benefit of semipermeable gloves in the prevention of occupational skin disease: (i) by minimizing glove-induced irritation and (ii) by enhancing barrier recovery through protective glove materials at the work place in cases of pre-existing minor irritant dermatitis."
4.	Air Bags (Airbags) 09/01/2004 - "In about 7%-8% of cases, air bags cause dermatologic injuries such as traumatic lesions, irritant dermatitis, and chemical and thermal burns. "
5.	Tattooing 09/01/2013 - "The onset and exacerbations of discoid lupus erythematosus (DLE) can be precipitated by several factors like needling, scratches, trauma, X-rays, heat, cold, pressure, tattooing, scars, allergic and irritant dermatitis and inflammatory dermatoses. "