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IgG Receptors (Fc gamma RI)

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Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).

Also Known As:

Fc gamma RI; Receptors, IgG; CD 16 Antigens; CD 32 Antigens; CD 64 Antigens; CDw32 Antigens; Fc gamma RII; Fc gamma RIII; Immunoglobulin G Receptor; Leu-11 Antigens; Antigens, CD 16; Antigens, CD 32; Antigens, CD 64; Antigens, CDw32; Antigens, Leu-11; Leu 11 Antigens; Receptor, Immunoglobulin G; Receptors, gamma Fc; gamma RI, Fc; gamma RII, Fc; gamma RIII, Fc; gamma Receptors, Fc; Antigens, CD16; Antigens, CD32; Antigens, CD64; CD16 Antigens; CD32 Antigens; CD64 Antigens; Fc Receptors, gamma; Fc gamma Receptors; Receptors, Fc gamma; gamma Fc Receptors

Networked: 345 relevant articles (11 outcomes, 28 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	van den Berg, W B: 6 articles (12/2011 - 12/2001)
2.	Bruhns, Pierre: 5 articles (06/2012 - 04/2003)
3.	Daëron, Marc: 4 articles (03/2012 - 06/2007)
4.	Radstake, T R D J: 4 articles (12/2011 - 03/2005)
5.	Mancardi, David A: 3 articles (03/2012 - 02/2011)
6.	Jönsson, Friederike: 3 articles (03/2012 - 02/2011)
7.	Iannascoli, Bruno: 3 articles (03/2012 - 02/2011)
8.	Cassard, Lydie: 3 articles (01/2010 - 11/2002)
9.	Sautès-Fridman, Catherine: 3 articles (01/2010 - 11/2002)
10.	Fremont, Daved H: 3 articles (10/2009 - 12/2006)

Related Diseases

1.	Neoplasms (Cancer) 08/01/1992 - "In the present study we tested the possibility that Fc gamma RII expressing tumor cells could interfere with the immune system. " 11/01/2010 - "Insights into the role of Fc gamma receptors (FcgammaRs) genetic variations in monoclonal antibody-based anti-cancer therapy." 10/01/2009 - "Anti-Gal further opsonizes the tumor cells and targets them for effective uptake by recruited APC, via Fc gamma receptors. " 12/01/2006 - "Fc gamma receptors and cancer." 07/01/1997 - "The bispecific monoclonal antibody (bsmAb) 2B1, targeting the extracellular domain of c-erbB-2, the protein product of the HER-2/neu proto-ocogene, and Fc gamma RIII (CD16), expressed by human natural killer cells, neutrophils and differentiated monocytes, mediates the specific cytotoxic activity of these effector cells to tumor cells. "
2.	Rheumatoid Arthritis 01/01/2007 - "Activating and inhibitory Fc gamma receptors in rheumatoid arthritis: from treatment to targeted therapies." 03/01/2005 - "Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors." 08/01/1996 - "Expression of Fc gamma RIII in neutrophils in rheumatoid arthritis." 04/01/1993 - "[Syndrome of T gamma lymphoproliferation of Fc gamma RIII- positive lymphocytes in rheumatoid arthritis]." 05/15/1992 - "The concentration of soluble Fc gamma RIII in the synovial fluid from patients with rheumatoid arthritis ranged from 10 nmol/L to 28 mumol/L. "
3.	Autoimmune Diseases (Autoimmune Disease) 09/01/2015 - "The human FCGR2/3 locus, containing five highly homologous genes encoding the major IgG receptors, shows extensive copy number variation (CNV) associated with susceptibility to autoimmune diseases. " 07/01/2005 - "The role for inhibitory Fc gamma receptors class IIb (FcgammaRIIb) in the onset, progression and severity of several animal models of autoimmune diseases is well established. " 01/01/2001 - "Fc gamma receptors also play a role in the pathophysiology of autoimmune diseases. " 11/01/1994 - "Fc gamma receptors, and in particular genetic variation in these receptors, are important in disorders of hose defense, immunohematologic disease, and systemic autoimmune diseases. " 05/01/2008 - "Immune complex (IC) binding to Fc gamma receptors (FcgammaRs) is central for inflammatory reactions seen in autoimmune diseases. "
4.	Thrombocytopenia (Thrombopenia) 12/01/1995 - "Thus, the Fc gamma RII phenotype regulates the in vitro activation response of normal platelets to HIT antibody and is a risk factor for the thrombocytopenia of HIT." 02/01/2009 - "Macrophages activated by C-reactive protein through Fc gamma RI transfer suppression of immune thrombocytopenia." 08/01/1997 - "Plasma levels of soluble Fc gamma receptors II (sCD32) and III (sCD16) in patients with heparin-induced thrombocytopenia." 04/01/1991 - "Investigation of the thrombocytopenia in these patients revealed that most patients presented with markedly elevated platelet associated IgG (PAIgG), elevated plasma platelet-bindable IgG (PBIgG), and an elevated number of monocyte Fc gamma receptors. " 10/01/2001 - "Clearance of autoantibody-sensitized platelets through Fc gamma receptors on phagocytic cells is one of the main mechanisms of thrombocytopenia in idiopathic thrombocytopenic purpura (ITP). "
5.	Acquired Immunodeficiency Syndrome (AIDS) 01/01/1993 - "However, only a minor proportion (16%, 20%, 20%, 25%, and 25% respectively) of human immunodeficiency virus infected patients (mostly with AIDS) had a significant reduction of the levels of CD4, CD14, CD45R, CD11b, and CD16 antigens in the alveolar macrophages. " 05/01/1991 - "By dual-fluorescence analysis using a monoclonal antibody specific for Fc gamma RIII (MAb 3G8), 38.5 +/- 3.2% of the LeuM3 (CD14)-positive monocytes in AIDS patients were CD16 positive as compared to 10.4 +/- 1.0% for healthy individuals (n = 29; P less than 0.005). " 05/01/1991 - "In contrast, we have observed that AIDS monocytes express significant levels of a third Fc gamma R, Fc gamma RIII (CD16), which is normally associated with activation or maturation of the monocyte population. " 02/01/1990 - "The presence of the Fc gamma RIII negative neutrophil population may be related to altered functions leading to common bacterial infections in advanced AIDS." 02/01/1990 - "In patients with AIDS and AIDS-related complex and in HIV-I positive intravenous drug abusers we observed a substantial population (25%) of neutrophils that were autofluorescent, and did not stain with the anti-Fc gamma RIII mAb 3G8. "

Related Drugs and Biologics

1.	Antigens
2.	Immunoglobulins (Immunoglobulin)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Intravenous Immunoglobulins (IVIG)
5.	Immunoglobulin G (IgG)
6.	Antigen-Antibody Complex (Immune Complex)
7.	Monoclonal Antibodies
8.	Complement System Proteins (Complement)
9.	Bispecific Antibodies
10.	Interferon-gamma (Interferon, gamma)

Related Therapies and Procedures

1.	Immunotherapy
2.	Heterologous Transplantation (Xenotransplantation)
3.	Ligation