Dopamine D1 Receptors (Dopamine D1 Receptor)

A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D1-class receptor genes lack INTRONS, and the receptors stimulate ADENYLATE CYCLASE.

Also Known As:

Networked: 193 relevant articles (6 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lokhandwala, Mustafa F: 7 articles (01/2011 - 11/2006)
2.	Greengard, Paul: 4 articles (09/2015 - 01/2009)
3.	Fisone, Gilberto: 4 articles (01/2011 - 01/2009)
4.	Abi-Dargham, Anissa: 3 articles (10/2014 - 05/2002)
5.	Dovero, Sandra: 3 articles (02/2014 - 01/2010)
6.	Laruelle, Marc: 3 articles (02/2014 - 05/2002)
7.	Nishi, Akinori: 3 articles (02/2012 - 08/2009)
8.	Valjent, Emmanuel: 3 articles (01/2011 - 08/2004)
9.	Yao, Jun: 2 articles (11/2015 - 01/2014)
10.	Schultz, Harold D: 2 articles (11/2015 - 07/2011)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 07/15/2013 - "The aim of this study was to develop a convenient model of the cognitive impairment observed in schizophrenia using common marmosets and the CANTAB system and to test whether a full agonist of the dopamine D1 receptor (SKF-81297) was effective against the cognitive impairment induced in this model. " 10/01/2014 - "Imaging studies have suggested that schizophrenia is associated with alterations in dopamine D1 receptor availability in the prefrontal cortex (PFC) that may be related to the WM impairments that characterize this disorder. " 10/28/2011 - "An association study between dopamine D1 receptor gene polymorphisms and the risk of schizophrenia." 05/22/2010 - "However, the results of previous positron emission tomography (PET) studies of dopamine D1 receptor in schizophrenia were not consistent. " 11/16/2015 - "The role of dopamine D1 receptor (DRD1) gene promoter polymorphisms in schizophrenia remains controversial. "
2.	Parkinson Disease (Parkinson's Disease) 12/21/1998 - "Furthermore, the data point to the possibility that a reduced dopaminergic tone at subthalamic dopamine D1 receptors might contribute to akinesia in Parkinson's disease." 08/01/1996 - "Potent dopamine D1 receptor agonists with an intermediate half-life may prove to be better adjuncts in the treatment of Parkinson's disease. " 04/22/1993 - "These results suggest a functional stimulatory role for the dopamine D1 receptor on motor behaviour in a non-human primate model of Parkinson's disease when stimulated with a high efficacy selective dopamine D1 receptor agonist." 01/01/1990 - "This restricted localisation mimics the major striatal dopamine D1 receptor localisation and is of major importance for the understanding of basal ganglia physiology and degenerative diseases pathogeny such as Huntington's and Parkinson's disease. " 05/01/1993 - "Dopamine D1 receptors in Parkinson's disease and striatonigral degeneration: a positron emission tomography study."
3.	Alcoholism (Alcohol Abuse) 10/01/1995 - "The present study examined the hypothesis that chronic alcoholism augments the age-related loss of dopamine D1 receptors. " 02/01/1999 - "In order to study the potential efficacy of dopamine receptor agonists in the treatment of alcohol abuse, the present study investigated the effects of several dopamine D1 receptor agonists with different intrinsic activities on ethanol self-administration in rats. "
4.	Acute Kidney Injury (Acute Renal Failure) 02/14/2003 - "The present study is the first demonstration for that a selective dopamine D1 receptor agonist is effective in preventing acute renal failure induced by cisplatin." 02/14/2003 - "Preventive effect of zelandopam, a dopamine D1 receptor agonist, on cisplatin-induced acute renal failure in rats." 02/14/2003 - "To elucidate the role of peripheral dopamine D1 receptors in cisplatin-induced acute renal injury, effect of zelandopam (YM435, (-)-(S)-4-(3,4-dihydroxyphenyl)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride hydrate), a selective renal dopamine D1 receptor agonist, on cisplatin-induced acute renal failure in rats was studied. "
5.	Seizures (Seizure) 06/01/2013 - "To construct dopamine D1 receptor (DRD1) expression interference vectors to study the role of DRD1 in nerve cells and lay a foundation for drug development in anti-convulsion. " 01/01/2001 - "The inference from a majority of studies is that the activation of dopamine D1 receptors facilitates seizure activity, whereas activation of D2 receptors may inhibit the development of seizures. " 07/14/2000 - "Seizures can be induced by systemic dopamine D1 receptor agonists or by cortical-limbic neurostimulation non-selectively. " 10/01/2014 - "Despite numerous studies showing therapeutic potential, no central dopamine D1 receptor ligand has ever been approved, because of potential limitations, such as hypotension, seizures, and tolerance. " 11/10/1992 - "The present study addressed the role of dopamine D1 receptors in pilocarpine-induced motor seizures in rats. "

Related Drugs and Biologics

1.	Dopamine D2 Receptors (Dopamine D2 Receptor)
2.	Dopamine Agonists (Dopamine Agonist)
3.	NNC 0756 (odapipam)
4.	Cisplatin (Platino)
5.	Ethanol (Ethyl Alcohol)
6.	Dopamine (Intropin)
7.	5- (2,3- dihydrobenzofuran- 7- yl)- 3- methyl- 8- nitro- 2,3,4,5- tetrahydro- 1H- 3- benzazepin- 7- ol
8.	A 86929
9.	NNC 112
10.	Scopolamine (Hyoscine)

Related Therapies and Procedures

1.	Self Administration (Administration, Self)
2.	Injections