Impromidine (SK&F-92676)

A highly potent and specific histamine H2 receptor agonist. It has been used diagnostically as a gastric secretion indicator.

Also Known As:

SK&F-92676; Impromidine Hydrochloride; Impromidine Oxalate (1:2); Impromidine Trihydrochloride; SKF-92676; Hydrochloride, Impromidine; SK&F 92676; SK&F92676; SKF 92676; SKF92676; Trihydrochloride, Impromidine; Guanidine, N-(3-(1H-imidazol-4-yl)propyl)-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-

Networked: 31 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Related Diseases

1.	Duodenal Ulcer (Curling's Ulcer) 07/01/1988 - "The effects of a specific H2 receptor agonist impromidine, on gastric acid secretion were measured in six patients with duodenal ulcer in clinical remission before and after three months treatment with ranitidine 150 mg nocte. " 01/01/1988 - "The interdigestive gastroduodenal motor activity was studied in 7 patients with active duodenal ulcer and increased gastric acid secretion, in 7 patients with hypersecretory gastroduodenitis and in 7 subjects with normal acid secretion, in whom the increase in acid secretion was obtained by means of the intravenous administration of an H2 agonist, Impromidine. "
2.	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 04/01/1985 - "First experiences in man indicate, that even in catecholamine-insensitive congestive cardiomyopathy a considerable improvement of myocardial function can be attained by the H2-receptor agonist impromidine. " 09/01/1987 - "[Effect of the stimulation of H2 receptors by impromidine in patients with idiopathic dilated cardiomyopathy]."
3.	Tachycardia (Tachyarrhythmias) 10/01/1982 - "In 12- or 14-day studies in dogs by the i.v. (maximum dose 0.259 mg per kg per day) and intramuscular (maximum dose 0.5 mg per kg per day) routes, impromidine caused vasodilation, tachycardia and vomiting. " 09/01/1981 - "The specificity of H-2 effect of impromidine was confirmed by simultaneous tachycardia and hypotension; pentagastrin did not produce cardiovascular effects. "
4.	Vomiting 10/01/1982 - "In 12- or 14-day studies in dogs by the i.v. (maximum dose 0.259 mg per kg per day) and intramuscular (maximum dose 0.5 mg per kg per day) routes, impromidine caused vasodilation, tachycardia and vomiting. "
5.	Respiratory Insufficiency (Respiratory Failure) 10/01/1982 - "Studies in anaesthetized rats, either spontaneously respiring or sustained by artificial respiration, indicate that, at acute doses, impromidine causes death by respiratory failure."

Related Drugs and Biologics

1.	Catecholamines
2.	Ranitidine (Zantac)
3.	Histamine (Histamine Dihydrochloride)
4.	Dimaprit
5.	Cimetidine (Biomet)
6.	Histamine Agonists
7.	Pentagastrin (Peptavlon)
8.	Impromidine (SK&F-92676)
9.	Isoproterenol (Isoprenaline)
10.	Burimamide

Related Therapies and Procedures

1.	Artificial Respiration (Mechanical Ventilation)
2.	Intravenous Administration
3.	Ligation
4.	Intravenous Infusions