Necrobiotic Disorders (Necrobiosis)

A group of disorders characterized by swelling, basophilia, and distortion of collagen bundles in the dermis.
Also Known As:
Necrobiosis; Disorder, Necrobiotic; Disorders, Necrobiotic; Necrobioses; Necrobiotic Disorder
Networked: 83 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Necrosis
2. Granuloma
3. Granuloma Annulare
4. Vasculitis (Vasculitides)
5. Necrobiotic Xanthogranuloma


1. Yamamoto, Toshiyuki: 2 articles (07/2013 - 01/2011)
2. Crowson, A Neil: 2 articles (05/2005 - 06/2002)
3. Magro, Cynthia M: 2 articles (05/2005 - 06/2002)
4. Riahi, Ryan R: 1 article (01/2015)
5. Rupley, Katherine A: 1 article (01/2015)
6. Hooper, Deirdre O'Boyle: 1 article (01/2015)
7. Konar, Karabi: 1 article (03/2014)
8. Rakshit, Arindam: 1 article (03/2014)
9. Sanyal, Saurabh: 1 article (03/2014)
10. Levkov, A A: 1 article (09/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Necrobiotic Disorders:
1. DNA (Deoxyribonucleic Acid)IBA
2. CollagenIBA
3. CholesterolIBA
01/01/2011 - "Histological evaluation demonstrated hyaline necrobiosis and granulomatous lesions composed of histiocytes (some with foamy cytoplasm), multinucleated giant cells, and numerous cholesterol crystals. "
02/01/1988 - "When cholesterol clefts are seen in biopsy specimens of necrobiosis, necrobiotic xanthogranuloma must be ruled out. "
05/01/1995 - "Necrobiotic xanthogranuloma is a rare disease marked by yellowish-brown plaques with destructive growth and a tendency to ulceration, which shows a characteristic histopathological pattern of palisading granuloma with foam cells, Touton's and foreign-body giant cells, bizarre multinuclear giant cells, cholesterol clefts and marked necrobiosis of the connective tissue. "
12/01/1993 - "We present the case of a patient with the classic clinical course of NPX but with many histologic features in common with NXG, namely, multinucleated lipophages, cholesterol clefts, and degeneration of collagen with associated cellular necrosis (necrobiosis). "
10/01/2000 - "Histopathologic examination showed all the major features of a necrobiotic xanthogranuloma (NX) involving the entire dermis and subcutis, including areas of necrobiosis with cholesterol clefts, granulomatous infiltrate with some bizarre giant cells, numerous Touton cells, foamy cells, lymphoid follicles with germinal centers, foci of plasma cells, and "Touton cell panniculitis." A laboratory investigation revealed only slightly increased titers of cholesterol, strong positivity of anti-Borrelia antibodies, and diffuse skeletal osteoporosis with fractures of seven vertebrae. "
4. MucinsIBA
5. Insulin (Novolin)FDA Link
6. EnzymesIBA
7. Dipyridamole (Persantine)FDA LinkGeneric
8. Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
9. Carboxylesterase (Hydrolase S)IBA
10. Polyethylene (Polythene)IBA

Therapies and Procedures

1. Lasers (Laser)
2. Cesarean Section (Caesarean Section)
3. Prostheses and Implants (Prosthesis)
4. Vagotomy
5. Sutures (Suture)