Necrobiotic Disorders (Necrobiosis)

01/01/1981 - "After cessation of drug administration the abnormally high ploidy cells are eliminated - probably by necrobiosis - and the liver cells return to their normal age-dependent DNA-ploidy level. "

01/01/2015 - "GA and NL are characterized histologically by areas of necrobiosis of collagen. "
08/01/2011 - "There was no apparent necrobiosis of collagen fibres. "
11/01/2008 - "Varying sized and shaped yeasts, capsules of varying width, capsular fragmentation and collagen necrobiosis were ultrastructurally confirmed. "
11/01/2008 - "Subepithelial neutrophils and collagen necrobiosis were identified in 8 and 14 cases each, respectively. "
03/01/2006 - "Histopathology reveals numerous xanthomous histiocytes and collagen necrobiosis. "

07/01/2017 - "Lipid vacuoles were seen within the foci of necrobiosis and xanthogranulomatous infiltration (Figure 2). "
01/01/1997 - "Hepatic ultrasonography seems to be a reliable and relatively sensitive method for monitoring liver dystrophy with necrobiosis and lipid accumulation and to follow the course of steatosis in clinical cases. "
03/01/1995 - "The lesion was characterized by vacuolar distention of chondrocytes, eventual necrobiosis, and formation of acellular pools of lipid material. "
06/01/1986 - "Extracellular lipid in EX separates and disrupts the reticular dermis, simulating necrobiosis. "
11/01/1976 - "Small cytoplasmic lipid globules and the diffuse sudanophilia of the finely dispersed lipids which paralleled the cyanophilia in the homologous cells were considered indicators of the functional status of well preserved urothelial cells; medium and large lipid globules were a sign of advanced necrobiosis. "

10/01/2006 - "The histology shows a granulomatous infiltrate without palisading image, made up of lymphocytes, histiocytes and giant cells, with phagocytosis of elastic fibers, without necrobiosis or mucin deposit. "
10/01/2018 - "Broadly, AG is characterized by granulomatous inflammation, multinucleated giant cells, elastophagocytosis, and the absence of mucin and necrobiosis. "
04/01/2013 - "GA has characteristic histological features of necrobiosis, granuloma formation and abundant mucin deposition. "
11/01/1979 - "The histopathology of the lesions showed many multinucleated giant cells, (often with prominent asteroid bodies), histiocytes, lymphocytes, scattered epithelioid cells, total lysis of elastic tissue, no necrobiosis, and absence of both mucin and lipid. "
08/15/2022 - "The presence of an inflammatory infiltration with non-palisading granulomas, multinucleate large cells, elastin degradation, and elastophagocytosis, as well as the absence of necrobiosis and mucin, are histopathological characteristics. "

06/15/2011 - "Histological evaluation demonstrated hyaline necrobiosis and granulomatous lesions composed of histiocytes (some with foamy cytoplasm), multinucleated giant cells, and numerous cholesterol crystals. "
03/01/1976 - "Typical findings are: Rather dense distribution of relatively small foam cells within the dermis, only a few foam giant cells, great amounts of cholesterol intra- and extracellulary, and circumscribed necrobioses. "
02/01/1988 - "When cholesterol clefts are seen in biopsy specimens of necrobiosis, necrobiotic xanthogranuloma must be ruled out. "
05/01/1995 - "Necrobiotic xanthogranuloma is a rare disease marked by yellowish-brown plaques with destructive growth and a tendency to ulceration, which shows a characteristic histopathological pattern of palisading granuloma with foam cells, Touton's and foreign-body giant cells, bizarre multinuclear giant cells, cholesterol clefts and marked necrobiosis of the connective tissue. "
03/01/2018 - "It revealed the complex ultrastructural alterations of cardiomyocytes and endotheliocytes (including the lytic and destructive changes of the intracellular organelles, upregulation of the autophagocytosis in the cardiomyocytes, and necrobiosis with apoptosis of endotheliocytes) reflecting the cytopathic features of circulating cholesterol and lipoproteins, whose elevation determined the intensity of destructive processes. "

12/01/1985 - "[Pathogenetic significance of the reduction in the concentration of insulin in the erythrocytes of patients with annular granuloma and lipoid necrobiosis]."
06/01/1974 - "[Treatment of lipoid necrobiosis in patients with diabetes mellitus with swine insulin]."
12/01/1983 - "HLA antigens and necrobiosis lipoidica diabeticorum--a comparison between insulin-dependent diabetics with and without necrobiosis."
12/01/1983 - "To investigate whether HLA-A, -B, -C, and -DR alloantigen frequencies are different in diabetic patients with and without necrobiosis lipoidica diabeticorum we studied 37 insulin-dependent (Type I) diabetics, 15 with and 22 without necrobiosis, and 96 normal control subjects. "

04/01/1994 - "We speculate that mast cell degranulation may be involved in the pathogenesis of necrobiosis by altering fibroblast enzyme activity and/or producing prolonged inflammatory reactions."
06/01/1976 - "The behavior of the mitochondrial GDH as well as of the lysosomal enzymes SP and BETA-GC which scarcely increased during the recirculations in the perfusate blood, however, allows the conclusion that there did not appear a severe lesion of the liver cells (necrobiosis) during several hours of perfusion. "
04/01/1977 - "Our observations suggest that necrosis of histiocytes and fibroblasts with release of lysosomal enzymes is an important early event in the development of necrobiosis. "

03/30/1976 - "After 8--24 h the ouabain application produces alterations in the retinal ganglion cells, that progress subsequently to necrobiosis. "
12/18/1975 - "The high doses of ouabain induced an early necrobiosis of the cell bodies in the retina followed by degeneration in the nerve. "

05/01/2016 - "The Azzopardi phenomenon was seen in cases with cystic pseudotumours characterised by superficial necrobiosis, proliferative desquamative synovitis, finding of metal and corrosion wear particles and cellular infiltration by macrophages. "
10/01/2011 - "Thus, neither necrobiosis nor infiltration of T-lymphocytes should be considered to be specific for failed metal-on-metal bearings or metal hypersensitivity reaction."
10/01/2011 - "Soft tissue necrobiosis and T-lymphocyte infiltration within the periprosthetic soft tissue have been linked to a suggested hypersensitivity reaction of the delayed-type following the metal-on-metal arthroplasty. "
10/01/2011 - "Thus, we wished to quantify the extent of necrobiosis and the amount of T-lymphocyte infiltration in aseptically loosened metal-on-polyethylene prostheses. "
10/01/2011 - "While we observed both synovial necrobiosis and lymphocyte infiltrates in synovial tissues with failed metal-on-polyethylene prostheses, we hypothesized that both findings are unspecific for metal-on-metal bearing coupes. "

11/01/1985 - "[Lipoprotein spectrum of the blood in patients with lipoid necrobiosis]."
03/01/2018 - "It revealed the complex ultrastructural alterations of cardiomyocytes and endotheliocytes (including the lytic and destructive changes of the intracellular organelles, upregulation of the autophagocytosis in the cardiomyocytes, and necrobiosis with apoptosis of endotheliocytes) reflecting the cytopathic features of circulating cholesterol and lipoproteins, whose elevation determined the intensity of destructive processes. "

01/01/2013 - "This paper deals with the main aspects of etiology and pathogensis, clinical picture and therapy of lipoid necrobiosis. "
01/01/1971 - "[Influence of therapy on experimental liver necrobiosis]."
09/01/1965 - "Compression therapy in ulcers of necrobiosis lipodica diabeticorum."
01/01/1977 - "Peculiar features of the case were dystrophic changes in cytomegalic cells subjected to necrobiosis, which, probably, was due to cytostatic therapy."

01/01/1951 - "[Myomectomy during pregnancy for aseptic necrobiosis]."
01/01/1997 - "In ten patients myomectomy was performed during cesarean section delivery to prevent necrobiosis. "
01/07/2019 - "She underwent an emergency caesarean section which fortuitously revealed aseptic necrobiosis of a uterine fibroid, managed within the same surgical intervention by myomectomy. "

01/01/1997 - "In ten patients myomectomy was performed during cesarean section delivery to prevent necrobiosis. "
06/01/1953 - "[Giant myoma of the ovary in necrobiosis and pregnancy; cesarean section and hysteroadnexectomy]."
01/07/2019 - "She underwent an emergency caesarean section which fortuitously revealed aseptic necrobiosis of a uterine fibroid, managed within the same surgical intervention by myomectomy. "

01/01/1991 - "Laser irradiation damage induced in these eukaryotic cells could be characterized by two development stages: a) a reversible stage with minor morphological damages (1.5 kJ/m2) and 2) an irreversible one, at higher fluences, characterized by cellular membrane damage, necrobiosis and cells detachment from the substrate (4.5 kJ/m2). "
11/01/1979 - "A definite difference was revealed in the size of zones of coagulated necrosis and necrobiosis of lingual myons situating lengthwise and across the axis of the laser ray. "

10/01/2011 - "Thus, we wished to quantify the extent of necrobiosis and the amount of T-lymphocyte infiltration in aseptically loosened metal-on-polyethylene prostheses. "
10/01/2011 - "While we observed both synovial necrobiosis and lymphocyte infiltrates in synovial tissues with failed metal-on-polyethylene prostheses, we hypothesized that both findings are unspecific for metal-on-metal bearing coupes. "
10/01/2011 - "We analyzed 28 consecutive synovial biopsy specimens obtained at revision surgery of aseptically loosened metal-on-polyethylene prostheses (19 hips and 9 knees) and quantified both the extent of necrobiosis vertically and the density of CD3+, CD4+, and CD8+ lymphocytes within the joint capsular tissue. "